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LINC00210 exerts oncogenic roles in glioma by sponging miR‑328

  • Authors:
    • Zhifei Wang
    • Hao Wu
    • Hui Yan
    • Tao Cai
    • Jin Dai
    • Qiang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 137
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    Published online on: October 2, 2020
       https://doi.org/10.3892/etm.2020.9266
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Abstract

Long non‑coding RNAs (lncRNAs) have been reported to serve key roles in human cancer types, including glioma. However, to the best of our knowledge, the expression and function of lncRNA LINC00210 in glioma have not previously been investigated. The present study was conducted to explore the regulatory role of LINC00210 in glioma cells. The present study demonstrated that LINC00210 was significantly upregulated in glioma tissues, and high expression of LINC00210 was significantly associated with advanced clinical stage and poor prognosis in patients with glioma. It was found that LINC00210 knockdown significantly inhibited the proliferation and migration of U251 and T98G cells. The results of luciferase reporter assays indicated that LINC00210 could directly target microRNA (miR)‑328 in glioma cells, and miR‑328 expression was negatively correlated with LINC00210 expression in glioma tissues. LINC00210 knockdown significantly promoted the expression of miR‑328 in U251 and T98G cells. Moreover, silencing miR‑328 impaired the inhibitory effects of LINC00210 knockdown on the proliferation and migration of U251 and T98G cells. Therefore, the present results suggested that LINC00210 may exert an oncogenic role in glioma via sponging miR‑328.
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1 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017.PubMed/NCBI View Article : Google Scholar

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015.PubMed/NCBI View Article : Google Scholar

3 

Peng Z, Liu C and Wu M: New insights into long noncoding RNAs and their roles in glioma. Mol Cancer. 17(61)2018.PubMed/NCBI View Article : Google Scholar

4 

Anjum K, Shagufta BI, Abbas SQ, Patel S, Khan I, Shah SAA, Akhter N and Hassan SSU: Current status and future therapeutic perspectives of glioblastoma multiforme (GBM) therapy: A review. Biomed Pharmacother. 92:681–689. 2017.PubMed/NCBI View Article : Google Scholar

5 

Zhou K, Zhang C, Yao H, Zhang X, Zhou Y, Che Y and Huang Y: Knockdown of long non-coding RNA NEAT1 inhibits glioma cell migration and invasion via modulation of SOX2 targeted by miR-132. Mol Cancer. 17(105)2018.PubMed/NCBI View Article : Google Scholar

6 

Smolle MA and Pichler M: The role of long non-coding RNAs in osteosarcoma. Noncoding RNA. 4(7)2018.PubMed/NCBI View Article : Google Scholar

7 

Xu S, Kong D, Chen Q, Ping Y and Pang D: Oncogenic long noncoding RNA landscape in breast cancer. Mol Cancer. 16(129)2017.PubMed/NCBI View Article : Google Scholar

8 

Zhang CJ, Liu C, Wang YX, Zhu N, Hu ZY, Liao DF and Qin L: Long non-coding RNA-SRA promotes neointimal hyperplasia and vascular smooth muscle cells proliferation via MEK-ERK-CREB pathway. Vascul Pharmacol. 116:16–23. 2019.PubMed/NCBI View Article : Google Scholar

9 

He D, Zeng H, Chen J, Xiao L, Zhao Y and Liu N: H19 regulates trophoblastic spheroid adhesion by competitively binding to let-7. Reproduction. 157:423–430. 2019.PubMed/NCBI View Article : Google Scholar

10 

Ma Z: Downregulation of SETD8 by miR-382 is involved in glioma progression. Pathol Res Pract. 214:356–360. 2018.PubMed/NCBI View Article : Google Scholar

11 

Bo H, Fan L, Gong Z, Liu Z, Shi L, Guo C, Li X, Liao Q, Zhang W, Zhou M, et al: Upregulation and hypomethylation of lncRNA AFAP1AS1 predicts a poor prognosis and promotes the migration and invasion of cervical cancer. Oncol Rep. 41:2431–2439. 2019.PubMed/NCBI View Article : Google Scholar

12 

Jiang H, Xiong W, Chen L, Lv Z, Yang C and Li Y: Knockdown of the long noncoding RNA HOTTIP inhibits cell proliferation and enhances cell sensitivity to cisplatin by suppressing the Wnt/β-catenin pathway in prostate cancer. J Cell Biochem. 120:8965–8974. 2019.PubMed/NCBI View Article : Google Scholar

13 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004.PubMed/NCBI View Article : Google Scholar

14 

Zhou S, Yu L, Xiong M and Dai G: lncRNA SNHG12 promotes tumorigenesis and metastasis in osteosarcoma by upregulating Notch2 by sponging miR-195-5p. Biochem Biophys Res Commun. 495:1822–1832. 2018.PubMed/NCBI View Article : Google Scholar

15 

Tan P, Guo YH, Zhan JK, Long LM, Xu ML, Ye L, Ma XY, Cui XJ and Wang HQ: lncRNA-ANRIL inhibits cell senescence of vascular smooth muscle cells by regulating miR-181a/Sirt1. Biochem Cell Biol. 97:571–580. 2019.PubMed/NCBI View Article : Google Scholar

16 

Lin C, Zhang Y, Chen Y and Bai Y: Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer. Cell Death Dis. 10(137)2019.PubMed/NCBI View Article : Google Scholar

17 

Fu X, Zhu X, Qin F, Zhang Y, Lin J, Ding Y, Yang Z, Shang Y, Wang L, Zhang Q and Gao Q: Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner. Mol Cancer. 17(73)2018.PubMed/NCBI View Article : Google Scholar

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

19 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004.PubMed/NCBI View Article : Google Scholar

20 

Tan Z, Zhao J and Jiang Y: miR-634 sensitizes glioma cells to temozolomide by targeting CYR61 through Raf-ERK signaling pathway. Cancer Med. 7:913–921. 2018.PubMed/NCBI View Article : Google Scholar

21 

Xiao F, Li Y, Wan Y and Xue M: MircroRNA-139 sensitizes ovarian cancer cell to cisplatin-based chemotherapy through regulation of ATP7A/B. Cancer Chemother Pharmacol. 81:935–947. 2018.PubMed/NCBI View Article : Google Scholar

22 

Zhu Y, Zhao H, Rao M and Xu S: MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3. Oncol Rep. 37:2185–2192. 2017.PubMed/NCBI View Article : Google Scholar

23 

Zhang J, Gong X, Tian K, Chen D, Sun J, Wang G and Guo M: miR-25 promotes glioma cell proliferation by targeting CDKN1C. Biomed Pharmacother. 71:7–14. 2015.PubMed/NCBI View Article : Google Scholar

24 

Wu Z, Sun L, Wang H, Yao J, Jiang C, Xu W and Yang Z: miR-328 expression is decreased in high-grade gliomas and is associated with worse survival in primary glioblastoma. PLoS One. 7(e47270)2012.PubMed/NCBI View Article : Google Scholar

25 

Yuan J, Zheng Z, Zheng Y, Lu X, Xu L and Lin L: microRNA-328 is a favorable prognostic marker in human glioma via suppressing invasive and proliferative phenotypes of malignant cells. Int J Neurosci. 126:145–153. 2016.PubMed/NCBI View Article : Google Scholar

26 

Wang Y, Wang M, Wei W, Han D, Chen X, Hu Q, Yu T, Liu N, You Y and Zhang J: Disruption of the EZH2/miRNA/β-catenin signaling suppresses aerobic glycolysis in glioma. Oncotarget. 7:49450–49458. 2016.PubMed/NCBI View Article : Google Scholar

27 

Zhang S, Li P, Zhao L and Xu L: LINC00210 as a miR-328-5p sponge promotes nasopharyngeal carcinoma tumorigenesis by activating NOTCH3 pathway. Biosci Rep. 38(BSR20181168)2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Wu H, Yan H, Cai T, Dai J and Liu Q: LINC00210 exerts oncogenic roles in glioma by sponging miR‑328. Exp Ther Med 20: 137, 2020.
APA
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., & Liu, Q. (2020). LINC00210 exerts oncogenic roles in glioma by sponging miR‑328. Experimental and Therapeutic Medicine, 20, 137. https://doi.org/10.3892/etm.2020.9266
MLA
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., Liu, Q."LINC00210 exerts oncogenic roles in glioma by sponging miR‑328". Experimental and Therapeutic Medicine 20.6 (2020): 137.
Chicago
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., Liu, Q."LINC00210 exerts oncogenic roles in glioma by sponging miR‑328". Experimental and Therapeutic Medicine 20, no. 6 (2020): 137. https://doi.org/10.3892/etm.2020.9266
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Wu H, Yan H, Cai T, Dai J and Liu Q: LINC00210 exerts oncogenic roles in glioma by sponging miR‑328. Exp Ther Med 20: 137, 2020.
APA
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., & Liu, Q. (2020). LINC00210 exerts oncogenic roles in glioma by sponging miR‑328. Experimental and Therapeutic Medicine, 20, 137. https://doi.org/10.3892/etm.2020.9266
MLA
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., Liu, Q."LINC00210 exerts oncogenic roles in glioma by sponging miR‑328". Experimental and Therapeutic Medicine 20.6 (2020): 137.
Chicago
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., Liu, Q."LINC00210 exerts oncogenic roles in glioma by sponging miR‑328". Experimental and Therapeutic Medicine 20, no. 6 (2020): 137. https://doi.org/10.3892/etm.2020.9266
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