Open Access

LINC00210 exerts oncogenic roles in glioma by sponging miR‑328

  • Authors:
    • Zhifei Wang
    • Hao Wu
    • Hui Yan
    • Tao Cai
    • Jin Dai
    • Qiang Liu
  • View Affiliations

  • Published online on: October 2, 2020     https://doi.org/10.3892/etm.2020.9266
  • Article Number: 137
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) have been reported to serve key roles in human cancer types, including glioma. However, to the best of our knowledge, the expression and function of lncRNA LINC00210 in glioma have not previously been investigated. The present study was conducted to explore the regulatory role of LINC00210 in glioma cells. The present study demonstrated that LINC00210 was significantly upregulated in glioma tissues, and high expression of LINC00210 was significantly associated with advanced clinical stage and poor prognosis in patients with glioma. It was found that LINC00210 knockdown significantly inhibited the proliferation and migration of U251 and T98G cells. The results of luciferase reporter assays indicated that LINC00210 could directly target microRNA (miR)‑328 in glioma cells, and miR‑328 expression was negatively correlated with LINC00210 expression in glioma tissues. LINC00210 knockdown significantly promoted the expression of miR‑328 in U251 and T98G cells. Moreover, silencing miR‑328 impaired the inhibitory effects of LINC00210 knockdown on the proliferation and migration of U251 and T98G cells. Therefore, the present results suggested that LINC00210 may exert an oncogenic role in glioma via sponging miR‑328.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Z, Wu H, Yan H, Cai T, Dai J and Liu Q: LINC00210 exerts oncogenic roles in glioma by sponging miR‑328. Exp Ther Med 20: 137, 2020
APA
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., & Liu, Q. (2020). LINC00210 exerts oncogenic roles in glioma by sponging miR‑328. Experimental and Therapeutic Medicine, 20, 137. https://doi.org/10.3892/etm.2020.9266
MLA
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., Liu, Q."LINC00210 exerts oncogenic roles in glioma by sponging miR‑328". Experimental and Therapeutic Medicine 20.6 (2020): 137.
Chicago
Wang, Z., Wu, H., Yan, H., Cai, T., Dai, J., Liu, Q."LINC00210 exerts oncogenic roles in glioma by sponging miR‑328". Experimental and Therapeutic Medicine 20, no. 6 (2020): 137. https://doi.org/10.3892/etm.2020.9266