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Article

Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels

  • Authors:
    • Mengyang Wang
    • Ning Li
    • Shu Jing
    • Chunmei Wang
    • Jinghui Sun
    • He Li
    • Jiale Liu
    • Jianguang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin 132013, P.R. China, Department of Pharmacy, The First Hospital of Jilin University, Changchun, Jilin 130000, P.R. China, Department of Neurology, Affiliated Hospital of Beihua University, Jilin, Jilin 132001, P.R. China, Department of Neurology, Jilin City Central Hospital, Jilin, Jilin 132001, P.R. China
  • Article Number: 142
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    Published online on: October 5, 2020
       https://doi.org/10.3892/etm.2020.9271
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Abstract

Schisandrin B (SchB) is one of the primary active components of Schisandra chinensis (Turcz.) Baill., a traditional Chinese herb that has been used to treat insomnia for hundreds of years. Our previous studies revealed that SchB exerts sedative and hypnotic effects, increasing the content of γ‑aminobutyric acid (GABA) and the expression of its receptors in the brain tissues of rats. 5‑hydroxytryptamine (5‑HT) is another important neurotransmitter involved in sleep regulation, although, to the best of our knowledge, there are no reports of its association with SchB. Therefore, the present study aimed to determine whether the hypnotic effect of SchB was partly due to alterations in the expression of 5‑HT. The results indicated that SchB reduced sleep latency and increased sleep duration in parachlorophenylalanine (PCPA)‑induced rats with insomnia by increasing 5‑HT and 5‑hydroxyindoleacetic acid, and upregulating the expression of the 5‑HT receptor 1A in the hypothalamus. SchB also increased the ratio of GABA to glutamic acid and the activity of glutamic acid decarboxylase, decreased the activity of GABA transaminase, and upregulated the expression of GABAA receptor α1 and GABAA receptor γ2 in the rat hypothalamus. These results suggested that SchB improved PCPA‑induced insomnia in rats, and its effects may be associated with the regulation of GABA and 5‑HT levels in the hypothalamus.
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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Li N, Jing S, Wang C, Sun J, Li H, Liu J and Chen J: Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels. Exp Ther Med 20: 142, 2020.
APA
Wang, M., Li, N., Jing, S., Wang, C., Sun, J., Li, H. ... Chen, J. (2020). Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels. Experimental and Therapeutic Medicine, 20, 142. https://doi.org/10.3892/etm.2020.9271
MLA
Wang, M., Li, N., Jing, S., Wang, C., Sun, J., Li, H., Liu, J., Chen, J."Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels". Experimental and Therapeutic Medicine 20.6 (2020): 142.
Chicago
Wang, M., Li, N., Jing, S., Wang, C., Sun, J., Li, H., Liu, J., Chen, J."Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels". Experimental and Therapeutic Medicine 20, no. 6 (2020): 142. https://doi.org/10.3892/etm.2020.9271
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Li N, Jing S, Wang C, Sun J, Li H, Liu J and Chen J: Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels. Exp Ther Med 20: 142, 2020.
APA
Wang, M., Li, N., Jing, S., Wang, C., Sun, J., Li, H. ... Chen, J. (2020). Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels. Experimental and Therapeutic Medicine, 20, 142. https://doi.org/10.3892/etm.2020.9271
MLA
Wang, M., Li, N., Jing, S., Wang, C., Sun, J., Li, H., Liu, J., Chen, J."Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels". Experimental and Therapeutic Medicine 20.6 (2020): 142.
Chicago
Wang, M., Li, N., Jing, S., Wang, C., Sun, J., Li, H., Liu, J., Chen, J."Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels". Experimental and Therapeutic Medicine 20, no. 6 (2020): 142. https://doi.org/10.3892/etm.2020.9271
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