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Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts

  • Authors:
    • Mengbi Lin
    • Yue Zheng
    • Qian Li
    • Yufang Liu
    • Qingfang Xu
    • Yuying Li
    • Wei Lai
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology and Venereology, the Third Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 163
    |
    Published online on: October 9, 2020
       https://doi.org/10.3892/etm.2020.9292
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Abstract

Circular RNAs (circRNAs) have been previously implicated in number of diseases. However, the roles of circRNAs in photoaging remain elusive. In the present study, to understand if photoaging influences the levels of circRNA expression, the expression of circRNAs in ultraviolet A (UVA)‑irradiated human dermal fibroblasts were profiled. A total of 128 circRNAs were identified to be differentially expressed (fold change >1.5; P<0.05) after UVA exposure, including 39 upregulated and 89 downregulated circRNAs. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes biological pathway analyses indicated that the differentially expressed circRNAs were associated with extracellular matrix organization and metabolism. The present study revealed an altered circRNA expression pattern in human dermal fibroblasts following UVA‑irradiation. These results provide not only a basis for in‑depth study of the mechanism of skin photoaging but also a new possibility for the prevention and treatment of photoaging and associated skin diseases.
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1 

Gilchrest BA: Photoaging. J Invest Dermatol. 133:E2–E6. 2013.PubMed/NCBI View Article : Google Scholar

2 

Weihermann AC, Lorencini M, Brohem CA and de Carvalho CM: Elastin structure and its involvement in skin photoaging. Int J Cosmet Sci. 39:241–247. 2017.PubMed/NCBI View Article : Google Scholar

3 

Schneider SL and Lim HW: Review of environmental effects of oxybenzone and other sunscreen active ingredients. J Am Acad Dermatol. 80:266–271. 2018.PubMed/NCBI View Article : Google Scholar

4 

Burke KE: Mechanisms of aging and development-a new understanding of environmental damage to the skin and prevention with topical antioxidants. Mech Ageing Dev. 172:123–130. 2017.PubMed/NCBI View Article : Google Scholar

5 

Ma DL and Vano-Galvan S: Actinic Granuloma. N Engl J Med. 376(475)2017.PubMed/NCBI View Article : Google Scholar

6 

Xie HF, Liu YZ, Du R, Wang B, Chen MT, Zhang YY, Deng ZL and Li J: MiR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1. Cell Death Dis. 8(e2663)2017.PubMed/NCBI View Article : Google Scholar

7 

Li M, Li L, Zhang X, Zhao H, Wei M, Zhai W, Wang B and Yan Y: LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts. Aging (Albany NY). 11:5992–6013. 2019.PubMed/NCBI View Article : Google Scholar

8 

Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB and Kjems J: The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 20:675–691. 2019.PubMed/NCBI View Article : Google Scholar

9 

Guo JU, Agarwal V, Guo H and Bartel DP: Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 15(409)2014.PubMed/NCBI View Article : Google Scholar

10 

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013.PubMed/NCBI View Article : Google Scholar

11 

Wang K, Long B, Liu F, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, et al: A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J. 7:2602–2611. 2016.PubMed/NCBI View Article : Google Scholar

12 

Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, et al: Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Lett. 388:208–219. 2017.PubMed/NCBI View Article : Google Scholar

13 

Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Hsu S, Ibanez L, Fernandez MV, Farias F, Norton J, et al: An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. Nat Neurosci. 22:1903–1912. 2019.PubMed/NCBI View Article : Google Scholar

14 

Chen FG, Zhang WJ, Bi D, Liu W, Wei X, Chen FF, Zhu L, Cui L and Cao Y: Clonal analysis of nestin(-) vimentin(+) multipotent fibroblasts isolated from human dermis. J Cell Sci. 120:2875–2883. 2007.PubMed/NCBI View Article : Google Scholar

15 

Lamore SD and Wondrak GT: UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts. J Photchem Photobiol B. 123:1–12. 2013.PubMed/NCBI View Article : Google Scholar

16 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43(e47)2015.PubMed/NCBI View Article : Google Scholar

17 

Livak K and Schmittgen T: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2000.PubMed/NCBI View Article : Google Scholar

18 

Park YM and Park SN: Inhibitory effect of lupeol on MMPs expression using aged fibroblast through repeated UVA Irradiation. Photochem Photobiol. 95:587–594. 2019.PubMed/NCBI View Article : Google Scholar

19 

Peng Y, Song X, Zheng Y, Cheng H and Lai W: circCOL3A1-859267 regulates type I collagen expression by sponging miR-29c in human dermal fibroblasts. Eur J Dermatol. 28:613–620. 2018.PubMed/NCBI View Article : Google Scholar

20 

Bouchie A: First microRNA mimic enters clinic. Nat Biotechnol. 31(577)2013.PubMed/NCBI View Article : Google Scholar

21 

Farrar MD: Advanced glycation end products in skin ageing and photoageing: What are the implications for epidermal function? Exp Dermatol. 25:947–948. 2016.PubMed/NCBI View Article : Google Scholar

22 

Beg MS, Brenner AJ, Sachdev J, Borad M, Kang YK, Stoudemire J, Smith S, Bader AG, Kim S and Hong DS: Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors. Invest New Drugs. 35:180–188. 2017.PubMed/NCBI View Article : Google Scholar

23 

Wong RR, Abd-Aziz N, Affendi S and Poh CL: Role of microRNAs in antiviral responses to dengue infection. J Biomed Sci. 27(4)2020.PubMed/NCBI View Article : Google Scholar

24 

Wheatley AK, Kramski M, Alexander MR, Toe JG, Center RJ and Purcell DF: Co-expression of miRNA targeting the expression of PERK, but not PKR, enhances cellular immunity from an HIV-1 Env DNA vaccine. PLoS One. 6(e18225)2011.PubMed/NCBI View Article : Google Scholar

25 

Zhou BR, Guo XF, Zhang JA, Xu Y, Li W, Wu D, Yin ZQ, Permatasari F and Luo D: Elevated miR-34c-5p mediates dermal fibroblast senescence by ultraviolet irradiation. Int J Biol Sci. 9:743–752. 2013.PubMed/NCBI View Article : Google Scholar

26 

Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C, et al: Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Rep. 10:170–177. 2015.PubMed/NCBI View Article : Google Scholar

27 

You X, Vlatkovic Babic A, Will T, Epstein Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, et al: Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci. 18:603–910. 2015.PubMed/NCBI View Article : Google Scholar

28 

Peng Y, Song X, Zheng Y, Wang X and Lai W: Circular RNA profiling reveals that circCOL3A1-859267 regulate type I collagen expression in photoaged human dermal fibroblasts. Biochem Biophys Res Commun. 486:277–284. 2017.PubMed/NCBI View Article : Google Scholar

29 

Xu D, Li D, Zhao Z, Wu J and Zhao M: Regulation by walnut protein hydrolysate on the components and structural degradation of photoaged skin in SD rats. Food Funct. 10:6792–6802. 2019.PubMed/NCBI View Article : Google Scholar

30 

Zhang X, Zhang G, Huang H, Li H, Lin S and Wang Y: Differentially expressed MicroRNAs in radioresistant and radiosensitive atypical meningioma: A clinical study in chinese patients. Front Oncol. 10(501)2020.PubMed/NCBI View Article : Google Scholar

31 

Quan T, He T, Kang S, Voorhees JJ and Fisher GJ: Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling. Am J Pathol. 165:741–751. 2004.PubMed/NCBI View Article : Google Scholar

32 

Battie C, Jitsukawa S, Bernerd F, Del Bino S, Marionnet C and Verschoore M: New insights in photoaging, UVA induced damage and skin types. Exp Dermatol. 23 (Suppl 1):7–12. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lin M, Zheng Y, Li Q, Liu Y, Xu Q, Li Y and Lai W: Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts. Exp Ther Med 20: 163, 2020.
APA
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., & Lai, W. (2020). Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts. Experimental and Therapeutic Medicine, 20, 163. https://doi.org/10.3892/etm.2020.9292
MLA
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., Lai, W."Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts". Experimental and Therapeutic Medicine 20.6 (2020): 163.
Chicago
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., Lai, W."Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts". Experimental and Therapeutic Medicine 20, no. 6 (2020): 163. https://doi.org/10.3892/etm.2020.9292
Copy and paste a formatted citation
x
Spandidos Publications style
Lin M, Zheng Y, Li Q, Liu Y, Xu Q, Li Y and Lai W: Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts. Exp Ther Med 20: 163, 2020.
APA
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., & Lai, W. (2020). Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts. Experimental and Therapeutic Medicine, 20, 163. https://doi.org/10.3892/etm.2020.9292
MLA
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., Lai, W."Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts". Experimental and Therapeutic Medicine 20.6 (2020): 163.
Chicago
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., Lai, W."Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts". Experimental and Therapeutic Medicine 20, no. 6 (2020): 163. https://doi.org/10.3892/etm.2020.9292
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