Emerging role of long non‑coding RNAs in pulmonary hypertension and their molecular mechanisms (Review)

Qin,Yuhan; Yan,Gaoliang; Qiao,Yong; Wang,Dong; Luo,Erfei; Hou,Jiantong; Tang,Chengchun

doi:10.3892/etm.2020.9293

Emerging role of long non‑coding RNAs in pulmonary hypertension and their molecular mechanisms (Review)

Authors:
- Yuhan Qin
- Gaoliang Yan
- Yong Qiao
- Dong Wang
- Erfei Luo
- Jiantong Hou
- Chengchun Tang
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Affiliations: Department of Cardiology, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, P.R. China
Published online on: October 9, 2020 https://doi.org/10.3892/etm.2020.9293
Article Number: 164
Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pulmonary hypertension (PH) is a life‑threatening cardiopulmonary condition caused by several pathogenic factors. All types of PH are characterized by the excessive proliferation of pulmonary artery endothelial cells and pulmonary artery smooth muscle cells, apoptosis resistance, pulmonary vascular remodeling, sustained elevated pulmonary arterial pressure, right heart failure and even death. Over the past decade, next generation sequencing, particularly RNA‑sequencing, has identified some long non‑coding RNAs (lncRNAs) that may act as regulators of cell differentiation, proliferation and apoptosis. Studies have shown that lncRNAs are closely associated with the development of several diseases, including cardiovascular diseases. In addition, a number of studies have reported that lncRNAs, including maternally expressed gene 3, metastasis‑associated lung adenocarcinoma transcript 1, taurine upregulated 1 and cancer susceptibility candidate 2, serve important roles in the pathogenesis of PH. Despite the development of novel drug treatments, the mortality rate of PH remains high with no evident downward trend. Therefore, certain lncRNAs may be considered as therapeutic targets for the treatment of incurable PH. The present review summarizes the latest research on lncRNAs and PH, aiming to briefly describe PH‑associated lncRNAs and their mechanisms of action.

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