Correlation between quality of life and disease severity of pediatric patients with atopic dermatitis

Sur,Mara; Boca,Andreea Nicoleta; Ilies,Roxana Flavia; Floca,Emanuela; Tataru,Alexandru; Sur,Lucia

doi:10.3892/etm.2020.9319

Correlation between quality of life and disease severity of pediatric patients with atopic dermatitis

Authors:
- Mara Sur
- Andreea Nicoleta Boca
- Roxana Flavia Ilies
- Emanuela Floca
- Alexandru Tataru
- Lucia Sur
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Affiliations: Department of Dermatology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania, Department of Pharmacology, Toxicology and Clinical Pharmacology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania, Department of Medical Genetics, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania, Department of Pediatrics, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Published online on: October 13, 2020 https://doi.org/10.3892/etm.2020.9319
Article Number: 189

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Abstract

Atopic dermatitis (AD) is a complex, chronic skin disorder with a broad spectrum of clinical aspects, characterized by abnormal skin barrier function. This has a significant impact on patients' quality of life (QoL), which represents a crucial parameter for their wellbeing. This study assessed the QoL of patients with AD by following parameters such as itching, disturbance of sleep, disturbance of play activity, and community activities. The study included 64 patients clinically diagnosed with AD, aged 0 to 16 years. QoL of patients with AD was measured by evaluating the QoL indices for infants and young children (IDQoL‑Infants' Dermatitis Quality of Life Index) and the QoL for children over 4 years (CDQoL‑Children's Dermatology Life Quality Index). The severity of the disease was also monitored by evaluating the SCORAD index. The major symptom for atopic dermatitis, pruritus, was found most frequently in our study and influenced patients' QoL. The study showed that the above questionnaires are efficient tools for correlating AD severity with QoL even in younger patients and could be included in current guidelines. This is the first study that analyzed the QoL of pediatric patients with atopic dermatitis in Romania and can constitute the basis for elaborating a more comprehensive disease management guidelines.

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1	Solomon I, Ilie M, Draghici C, Voiculescu VM, Căruntu C, Boda D and Zurac S: The impact of lifestyle factors on evolution of atopic dermatitis: An alternative approach (Review). Exp Ther Med 1078-1084, 2018.
2	Olsen JR, Gallacher J, Finlay AY, Piguet V and Francis NA: Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): A meta-analysis. Br J Dermatol. 174:853–861. 2016.PubMed/NCBI View Article : Google Scholar
3	Kage P, Simon J and Treudler R: Atopic dermatitis and psychosocial comorbidities. J Dtsch Dermatol Ges. 18:93–102. 2020.PubMed/NCBI View Article : Google Scholar
4	Olsson M, Bajpai R, Yew YW, Koh MJA, Thng S, Car J and Järbrink K: Associations between health-related quality of life and health care costs among children with atopic dermatitis and their caregivers: A cross-sectional study. Pediatr Dermatol. 37:284–293. 2020.PubMed/NCBI View Article : Google Scholar
5	Holm J, Agner T, Clausen ML and Thomsen S: Quality of life and disease severity in patients with atopic dermatitis. J Eur Acad Dermatol Venereol. 30:1760–1767. 2016.PubMed/NCBI View Article : Google Scholar
6	Ražnatović Đurović M, Janković J, Tomić Spirić V, Relić M, Sojević Timotijević Z, Ćirković A, Đurić S and Janković S: Does age influence the quality of life in children with atopic dermatitis? PLoS One. 14(e0224618)2019.PubMed/NCBI View Article : Google Scholar
7	Xerfan EMS, Tomimori J, Andersen ML, Tufik S and Facina AS: Sleep disturbance and atopic dermatitis: A bidirectional relationship? Med Hypotheses. 140(109637)2020.PubMed/NCBI View Article : Google Scholar
8	Chernyshov PV: Stigmatization and self-perception in children with atopic dermatitis. Clin Cosmet Investig Dermatol. 9:159–166. 2016.PubMed/NCBI View Article : Google Scholar
9	Xu X, van Galen LS, Koh MJA, Bajpai R, Thng S, Yew YW, Ho VPY, Alagappan U, Järbrink KSA and Car J: Factors influencing quality of life in children with atopic dermatitis and their caregivers: A cross-sectional study. Sci Rep. 9(15990)2019.PubMed/NCBI View Article : Google Scholar
10	Gabes M, Chamlin SL, Lai J, Cella D, Mancini AJ and Apfelbacher CJ: Development of a validated short-form of the Childhood Atopic Dermatitis Impact Scale, the CADIS-SF15. J Eur Acad Dermatol Venereol: Mar 16, 2020 doi: 10.1111/jdv.16362. (Online ahead of print).
11	Gerbens LAA, Prinsen CAC, Chalmers JR, Drucker AM, von Kobyletzki LB, Limpens J, Nankervis H, Svensson Å, Terwee CB, Zhang J, et al: Evaluation of the measurement properties of symptom measurement instruments for atopic eczema: A systematic review. Allergy Eur J Allergy Clin Immunol. 72:146–163. 2017.PubMed/NCBI View Article : Google Scholar
12	Campos ALB, Araújo FM, Santos MALD, Santos AASD and Pires CAA: Impact of atopic dermatitis on the quality of life of pediatric patients and their guardians. Rev Paul Pediatr. 35:5–10. 2017.PubMed/NCBI View Article : Google Scholar
13	Chernyshov PV, Ho RC, Monti F, Jirakova A, Velitchko SS, Hercogova J and Neri E: Gender differences in self-assessed health-related quality of life in children with atopic dermatitis. J Clin Aesthet Dermatol. 9:19–24. 2016.PubMed/NCBI
14	Harrison IP and Spada F: Breaking the itch-scratch cycle: Topical options for the management of chronic cutaneous itch in atopic dermatitis. Medicines (Basel). 6(76)2019.PubMed/NCBI View Article : Google Scholar
15	El Hachem M, Di Mauro G, Rotunno R, Giancristoforo S, De Ranieri C, Carlevaris CM, Verga MC and Dello Iacono I: Pruritus in pediatric patients with atopic dermatitis: A multidisciplinary approach - summary document from an Italian expert group. Ital J Pediatr. 46(11)2020.PubMed/NCBI View Article : Google Scholar
16	Yang EJ, Beck KM, Sekhon S, Bhutani T and Koo J: The impact of pediatric atopic dermatitis on families: A review. Pediatr Dermatol. 36:66–71. 2019.PubMed/NCBI View Article : Google Scholar
17	Ramirez FD, Chen S, Langan SM, Prather AA, McCulloch CE, Kidd SA, Cabana MD, Chren MM and Abuabara K: Association of atopic dermatitis with sleep quality in children. JAMA Pediatr. 173(e190025)2019.PubMed/NCBI View Article : Google Scholar
18	Bonamonte D, Filoni A, Vestita M, Romita P, Foti C and Angelini G: The role of the environmental risk factors in the pathogenesis and clinical outcome of atopic dermatitis. Biomed Res Int. 2019(2450605)2019.PubMed/NCBI View Article : Google Scholar
19	Na CH, Chung J and Simpson EL: Quality of life and disease impact of atopic dermatitis and psoriasis on children and their families. Children (Basel). 6(133)2019.PubMed/NCBI View Article : Google Scholar
20	Maksimovic N, Zaric M, Reljic V, Nikolic M and Gazibara T: Factors associated with improvement of quality of life among parents of children with atopic dermatitis: 1-year prospective cohort study. J Eur Acad Dermatology Venereol. 34:325–332. 2020.PubMed/NCBI View Article : Google Scholar
21	Al-Afif KAM, Buraik MA, Buddenkotte J, Mounir M, Gerber R, Ahmed HM, Tallman AM and Steinhoff M: Understanding the burden of atopic dermatitis in Africa and the Middle East. Dermatol Ther (Heidelb). 9:223–241. 2019.PubMed/NCBI View Article : Google Scholar