Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review

Badulescu,Oana Viola; Filip,Nina; Sirbu,Paul Dan; Bararu‑Bojan,Iris; Vladeanu,Maria; Bojan,Andrei; Ciocoiu,Manuela

doi:10.3892/etm.2020.9337

Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review

Authors:
- Oana Viola Badulescu
- Nina Filip
- Paul Dan Sirbu
- Iris Bararu‑Bojan
- Maria Vladeanu
- Andrei Bojan
- Manuela Ciocoiu
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Affiliations: Department of Pathophysiology, Morpho‑Functional Sciences (II), Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Biochemistry, Morpho‑Functional Sciences (II), Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Orthopedics and Traumatology Surgical Sciences (II), Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Surgical Sciences, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
Published online on: October 14, 2020 https://doi.org/10.3892/etm.2020.9337
Article Number: 207

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Abstract

Haemophilia is an inherited disease that requires a different approach in order to evaluate, monitor and treat patients. Despite the great advances in therapeutic agents that have emerged, reports on the impact of monitoring outcomes on treatment decisions are rarely presented. Haemophilia A and haemophilia B are inherited bleeding disorders caused by deficiencies in blood clotting factor proteins. A systematic review was performed to identify literature reports on the current practices in haemophilic patients undergoing orthopedic surgery. The best therapy for haemophilic patients consists in performing primary prophylaxis to prevent joint bleeding and other complications. Besides the primary prophylaxis, thromboprophylaxis is used to prevent venous thrombosis in patients with hemophilia who undergo surgical orthopedic procedures. Further research is needed to better manage the pharmacologic approaches in haemophilic patients undergoing orthopedic surgery. Although patients with haemophilia present low risk for thromboembolic complications, such events have been reported in surgical procedures. The recommendations in patients with haemophilia are considerably variable in the current guidelines and clinical practice. The best therapy for haemophilic patients consists in performing primary prophylaxis to prevent joint bleeding and other complications.

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