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Article

Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review

  • Authors:
    • Oana Viola Badulescu
    • Nina Filip
    • Paul Dan Sirbu
    • Iris Bararu‑Bojan
    • Maria Vladeanu
    • Andrei Bojan
    • Manuela Ciocoiu
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Morpho‑Functional Sciences (II), Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Biochemistry, Morpho‑Functional Sciences (II), Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Orthopedics and Traumatology Surgical Sciences (II), Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Surgical Sciences, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
  • Article Number: 207
    |
    Published online on: October 14, 2020
       https://doi.org/10.3892/etm.2020.9337
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Abstract

Haemophilia is an inherited disease that requires a different approach in order to evaluate, monitor and treat patients. Despite the great advances in therapeutic agents that have emerged, reports on the impact of monitoring outcomes on treatment decisions are rarely presented. Haemophilia A and haemophilia B are inherited bleeding disorders caused by deficiencies in blood clotting factor proteins. A systematic review was performed to identify literature reports on the current practices in haemophilic patients undergoing orthopedic surgery. The best therapy for haemophilic patients consists in performing primary prophylaxis to prevent joint bleeding and other complications. Besides the primary prophylaxis, thromboprophylaxis is used to prevent venous thrombosis in patients with hemophilia who undergo surgical orthopedic procedures. Further research is needed to better manage the pharmacologic approaches in haemophilic patients undergoing orthopedic surgery. Although patients with haemophilia present low risk for thromboembolic complications, such events have been reported in surgical procedures. The recommendations in patients with haemophilia are considerably variable in the current guidelines and clinical practice. The best therapy for haemophilic patients consists in performing primary prophylaxis to prevent joint bleeding and other complications.
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1 

Peyvandi F, Palla R, Menegatti M and Mannucci PM: Introduction: Rare bleeding disorders: General aspects of clinical features, diagnosis and management. Semin Thromb Hemost. 35:349–355. 2009.PubMed/NCBI View Article : Google Scholar

2 

Murray RK, Granner DK, Mayes PA and Rodwell VW: Harper's Biochemistry. 25th Edition, McGraw-Hill, Health Profession Division, New York, 225, 2000.

3 

World Federation of Hemophilia. WFH guidelines for the management of hemophilia. Available at: urihttps://www1.wfh.org/publication/files/pdf-1472.pdfsimplehttps://www1.wfh.org/publication/files/pdf-1472.pdf.

4 

Rodriguez-Merchan EC: Prevention of the musculoskeletal complications of hemophilia. Adv Prev Med. 2012(201271)2012.PubMed/NCBI View Article : Google Scholar

5 

Knobe K and Berntorp E: Haemophilia and joint disease: Pathophysiology, evaluation, and management. J Comorb. 1:51–59. 2011.PubMed/NCBI View Article : Google Scholar

6 

Rizzo AR, Zago M, Carulli C and Innocenti M: Orthopaedic procedures in haemophilia. Clin Cases Miner Bone Metab. 14:197–199. 2017.PubMed/NCBI View Article : Google Scholar

7 

Rodríguez-Merchán EC: The role of orthopaedic surgery in haemophilia: Current rationale, indications and results. EFORT Open Rev. 4:165–173. 2019.PubMed/NCBI View Article : Google Scholar

8 

Journeycake JM, Miller KL, Anderson AM, Buchanan GR and Finnegan M: Arthroscopic synovectomy in children and adolescents with hemophilia. J Pediatr Hematol Oncol. 25:726–731. 2003.PubMed/NCBI View Article : Google Scholar

9 

Panotopoulos J, Hanslik-Schnabel B, Wanivenhaus A and Trieb K: Outcome of surgical concepts in haemophilic arthropathy of the hindfoot. Haemophilia. 11:468–471. 2005.PubMed/NCBI View Article : Google Scholar

10 

Luck JV Jr, Silva M, Rodriguez-Merchan CE, Ghalambor N, Zahiri CA and Finn RS: Hemophilic arthropathy. J Am Acad Orthop Surg. 12:234–245. 2004.PubMed/NCBI View Article : Google Scholar

11 

Rodriguez-Merchan EC: The haemophilic ankle. Haemophilia. 12:337–344. 2006.PubMed/NCBI View Article : Google Scholar

12 

Badulescu OV, Ciocoiu M, Filip N and Veringa V: The efficiency of substitutive treatment with moroctocog alfa in managing hemostasis in patients with hemophilia A without inhibitors with total knee arthroplasties. Rev Chim-Bucharest. 69:3702–3704. 2018.

13 

d'Oiron R, Pipe SW and Jacquemin M: Mild/moderate haemophilia A: New insights into molecular mechanisms and inhibitor development. Haemophilia. 14 (Suppl 3):S138–S146. 2008.PubMed/NCBI View Article : Google Scholar

14 

Badulescu OV, Ciocoiu M, Filip N and Veringa V: Tranexamic acid-major antifibrinolytic agent used to achieve hemostasis in hemophilic patients with anti-factor VIII antibodies who must undergo total joint replacement. Rev Chim-Bucharest. 70:638–641. 2019.

15 

Holme PA and Tjønnfjord GE: Continuous infusion of simoctocog Alfa in haemophilia A patients undergoing surgeries. Haemophilia. 25:54–59. 2009.PubMed/NCBI View Article : Google Scholar

16 

Silva M and Luck JV Jr: Long-term results of primary total knee replacement in patients with hemophilia. J Bone Joint Surg Am. 87:85–91. 2005.PubMed/NCBI View Article : Google Scholar

17 

Knesek D, Peterson TC and Markel DC: Thromboembolic prophylaxis in total joint arthroplasty. Thrombosis. 2012(837896)2012.PubMed/NCBI View Article : Google Scholar

18 

Gali JC and Camargo DB: Thromboprophylaxis for total knee arthroplasty. Rev Bras Ortop (Sao Paulo). 54:1–5. 2019.PubMed/NCBI View Article : Google Scholar

19 

Rodríguez-Merchán EC and De la Corte-García H: Orthopedic surgery in hemophilia: Is thromboprophylaxis necessary? Joint surgery in the adult patient with hemophilia. Springer, Cham, pp83-87, 2015.

20 

Ozelo MC: Surgery in patients with hemophilia: Is thromboprophylaxis mandatory? Thromb Res. 130 (Suppl 1):S23–S26. 2012.PubMed/NCBI View Article : Google Scholar

21 

Dargaud Y, Meunier S and Negrier C: Haemophilia and thrombophilia: An unexpected association! Haemophilia. 10:319–326. 2004.PubMed/NCBI View Article : Google Scholar

22 

Krekeler S, Alesci S and Miesbach W: Incidence of thromboembolic events after major operations in patients with haemophilia. Hamostaseologie. 32 (Suppl 1):S45–S47. 2012.(In German). PubMed/NCBI

23 

Hosseini F, Squire SJ, Younger AS and Jackson SC: A 13-year review of elective orthopaedic surgery outcomes in patients with hemophilia A and B. BC Med J. 61:250–255. 2019.

24 

Rampal V, Odent T, Torchet MF, Rothschild C, Elie C, Glorion C and Padovani JP: Surgical synovectomy of the knee in young haemophiliacs: Long-term results of a monocentric series of 23 patients. J Child Orthop. 4:33–37. 2010.PubMed/NCBI View Article : Google Scholar

25 

Yoon KH, Bae DK, Kim HS and Song SJ: Arthroscopic synovectomy in haemophilic arthropathy of the knee. Int Orthop. 29:296–300. 2005.PubMed/NCBI View Article : Google Scholar

26 

Wu LT, Lu HT, Chen CH, Ko A and Lee CH: Arthroscopic synovectomy considerably reduces bleeding frequency and improves joint function in hemophilic patients with chronic synovitis. Formos J Surg. 49:49–55. 2016.

27 

Caviglia H, Eljatib A, Del Soldato G, Daffunchio C, Landro ME and Neme D: Complications of ankle arthroscopy synovectomy. In: Haemophilia. Wiley, NJ, p82, 2018.

28 

Trieb K, Panotopoulos J, Hartl H, Brodner W, Pabinger I and Wanivenhaus A: Outcome of osteotomies for the treatment of haemophilic arthropathy of the knee. Langenbeck Arch Surg. 389:209–212. 2004.PubMed/NCBI View Article : Google Scholar

29 

Wallny T, Saker A, Hofmann P, Brackmann HH, Nicolay C and Kraft CN: Long-term follow-up after osteotomy for haemophilic arthropathy of the knee. Haemophilia. 9:69–75. 2003.PubMed/NCBI View Article : Google Scholar

30 

De l'Escalopier N, Badina A, Padovani JP, Harroche A, Frenzel L, Wicart P, Glorion C and Rothschild C: Long-term results of ankle arthrodesis in children and adolescents with haemophilia. Int Orthop. 41:1579–1584. 2017.PubMed/NCBI View Article : Google Scholar

31 

Fong JY, Luck JV and Silva M: Ankle fusion in hemophilia. In: Annual Meeting. San Diego, CA: American Academy of Orthopaedic Surgery, 2007.

32 

Moore MF, Tobase P and Allen DD: Meta-analysis: Outcomes of total knee arthroplasty in the haemophilia population. Haemophilia. 22:e275–e285. 2016.PubMed/NCBI View Article : Google Scholar

33 

Carulli C, Felici I, Martini C, Civinini R, Linari S, Castaman G and Innocenti M: Total hip arthroplasty in haemophilic patients with modern cementless implants. J Arthroplasty. 30:1757–1760. 2015.PubMed/NCBI View Article : Google Scholar

34 

Strauss AC, Rommelspacher Y, Nouri B, Bornemann R, Wimmer MD, Oldenburg J, Pennekamp PH and Schmolders J: Long-term outcome of total hip arthroplasty in patients with haemophilia. Haemophilia. 23:129–134. 2017.PubMed/NCBI View Article : Google Scholar

35 

Doets HC, Brand R and Nelissen RG: Total ankle arthroplasty in inflammatory joint disease with use of two mobile-bearing designs. J Bone Joint Surg Am. 88:1272–1284. 2006.PubMed/NCBI View Article : Google Scholar

36 

Radossi P, Bisson R, Munari F, Risato R, Tassinari C, Sartori R and Tagariello G: Total ankle replacement for end-stage arthropathy in patients with haemophilia. Haemophilia. 14:658–660. 2008.PubMed/NCBI View Article : Google Scholar

37 

Van Der Heide HJ, Nováková I and de Waal Malefijt MC: The feasibility of total ankle prosthesis for severe arthropathy in haemophilia and prothrombin deficiency. Haemophilia. 12:679–682. 2006.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Badulescu OV, Filip N, Sirbu PD, Bararu‑Bojan I, Vladeanu M, Bojan A and Ciocoiu M: Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review. Exp Ther Med 20: 207, 2020.
APA
Badulescu, O.V., Filip, N., Sirbu, P.D., Bararu‑Bojan, I., Vladeanu, M., Bojan, A., & Ciocoiu, M. (2020). Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review. Experimental and Therapeutic Medicine, 20, 207. https://doi.org/10.3892/etm.2020.9337
MLA
Badulescu, O. V., Filip, N., Sirbu, P. D., Bararu‑Bojan, I., Vladeanu, M., Bojan, A., Ciocoiu, M."Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review". Experimental and Therapeutic Medicine 20.6 (2020): 207.
Chicago
Badulescu, O. V., Filip, N., Sirbu, P. D., Bararu‑Bojan, I., Vladeanu, M., Bojan, A., Ciocoiu, M."Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review". Experimental and Therapeutic Medicine 20, no. 6 (2020): 207. https://doi.org/10.3892/etm.2020.9337
Copy and paste a formatted citation
x
Spandidos Publications style
Badulescu OV, Filip N, Sirbu PD, Bararu‑Bojan I, Vladeanu M, Bojan A and Ciocoiu M: Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review. Exp Ther Med 20: 207, 2020.
APA
Badulescu, O.V., Filip, N., Sirbu, P.D., Bararu‑Bojan, I., Vladeanu, M., Bojan, A., & Ciocoiu, M. (2020). Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review. Experimental and Therapeutic Medicine, 20, 207. https://doi.org/10.3892/etm.2020.9337
MLA
Badulescu, O. V., Filip, N., Sirbu, P. D., Bararu‑Bojan, I., Vladeanu, M., Bojan, A., Ciocoiu, M."Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review". Experimental and Therapeutic Medicine 20.6 (2020): 207.
Chicago
Badulescu, O. V., Filip, N., Sirbu, P. D., Bararu‑Bojan, I., Vladeanu, M., Bojan, A., Ciocoiu, M."Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review". Experimental and Therapeutic Medicine 20, no. 6 (2020): 207. https://doi.org/10.3892/etm.2020.9337
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