Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review

  • Authors:
    • Oana Viola Badulescu
    • Nina Filip
    • Paul Dan Sirbu
    • Iris Bararu‑bojan
    • Maria Vladeanu
    • Andrei Bojan
    • Manuela Ciocoiu
  • View Affiliations

  • Published online on: October 14, 2020     https://doi.org/10.3892/etm.2020.9337
  • Article Number: 207
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Abstract

Haemophilia is an inherited disease that requires a different approach in order to evaluate, monitor and treat patients. Despite the great advances in therapeutic agents that have emerged, reports on the impact of monitoring outcomes on treatment decisions are rarely presented. Haemophilia A and haemophilia B are inherited bleeding disorders caused by deficiencies in blood clotting factor proteins. A systematic review was performed to identify literature reports on the current practices in haemophilic patients undergoing orthopedic surgery. The best therapy for haemophilic patients consists in performing primary prophylaxis to prevent joint bleeding and other complications. Besides the primary prophylaxis, thromboprophylaxis is used to prevent venous thrombosis in patients with hemophilia who undergo surgical orthopedic procedures. Further research is needed to better manage the pharmacologic approaches in haemophilic patients undergoing orthopedic surgery. Although patients with haemophilia present low risk for thromboembolic complications, such events have been reported in surgical procedures. The recommendations in patients with haemophilia are considerably variable in the current guidelines and clinical practice. The best therapy for haemophilic patients consists in performing primary prophylaxis to prevent joint bleeding and other complications.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Badulescu OV, Filip N, Sirbu PD, Bararu‑bojan I, Vladeanu M, Bojan A and Ciocoiu M: Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review. Exp Ther Med 20: 207, 2020
APA
Badulescu, O.V., Filip, N., Sirbu, P.D., Bararu‑bojan, I., Vladeanu, M., Bojan, A., & Ciocoiu, M. (2020). Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review. Experimental and Therapeutic Medicine, 20, 207. https://doi.org/10.3892/etm.2020.9337
MLA
Badulescu, O. V., Filip, N., Sirbu, P. D., Bararu‑bojan, I., Vladeanu, M., Bojan, A., Ciocoiu, M."Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review". Experimental and Therapeutic Medicine 20.6 (2020): 207.
Chicago
Badulescu, O. V., Filip, N., Sirbu, P. D., Bararu‑bojan, I., Vladeanu, M., Bojan, A., Ciocoiu, M."Current practices in haemophilic patients undergoing orthopedic surgery ‑ a systematic review". Experimental and Therapeutic Medicine 20, no. 6 (2020): 207. https://doi.org/10.3892/etm.2020.9337