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Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response

  • Authors:
    • Haoliang Zhou
    • Yuxiang Yan
    • Xianbo Zhang
    • Ting Zhao
    • Jiangang Xu
    • Ruokuo Han
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    Affiliations: Department of Oncology, Wenzhou Central Hospital, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 229
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    Published online on: October 15, 2020
       https://doi.org/10.3892/etm.2020.9359
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Abstract

Ginseng polysaccharide (GPS) is known for its efficacy in cancer therapy; however, its regulatory mechanism in breast cancer (BC) remains unclear. To analyze the effect of GPS on BC cell proliferation, cell proliferation rate calculations, western blotting, plasmid transfections, electrophoretic mobility shift assays and chromatin immunoprecipitation assays were performed. GPS treatment in the culture cell medium inhibited cell proliferation in the BC cell line MDA‑MB‑231. In addition, the E‑cadherin level was enhanced while the vimentin level was suppressed following GPS treatment (both P<0.05). Furthermore, the levels of apoptotic markers, including cleaved‑Caspase‑3 and p53, and inflammatory response markers, including plasminogen activator inhibitor and TNF‑α, were induced by GPS treatment in MDA‑MB‑231 cells (all P<0.05). These results indicated that GPS supplementation activated the inflammatory response and apoptosis in BC cells. GPS treatment activated the phosphorylation levels of c‑Jun N‑terminal kinase, Akt and NF‑κB. In MDA‑MB‑231 cells, GPS resulted in the accumulation of the NF‑κB components p65, p50 and Ikaros family zing finger protein 1 (IKZF1; all, P<0.05). Chromatin immunoprecipitation and electrophoretic mobility shift assays indicated that p65 bound to the IKZF1 promoter. The overexpression of IKZF1 or p65 inhibited MDA‑MB‑231 cell proliferation (P<0.05), indicating that GPS treatment may inhibit BC cell proliferation by the activation of IKZF1. Taken together, these results suggested that GPS significantly inhibited BC cell proliferation via the control of the biological processes, including the activation of p65‑IKZF1 signaling and apoptosis. The data indicated a novel mechanism for further understanding of cancer cell proliferation.
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1 

National Cancer Institute: Cancer topics: Breast cancer, 2014. Accessed 5 Jan 2015. 2015:1-1.

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Cancer incidence and mortality worldwide: IARC Cancer Base no. 10. GLOBOCAN 2008. Lyon: International Agency for Research on Cancer, 2010.

3 

Han Z, Wei B, Zheng Y, Yin Y, Li K and Li S: Breast cancer multi-classification from histopathological images with structured deep learning model. Sci Rep. 7(4172)2017.PubMed/NCBI View Article : Google Scholar

4 

Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A and Muñoz M: Clinical implications of the intrinsic molecular subtypes of breast cancer. Breast. 24 (Suppl 2):S26–S35. 2015.PubMed/NCBI View Article : Google Scholar

5 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001.PubMed/NCBI View Article : Google Scholar

6 

Wilson S and Chia SK: Treatment algorithms for hormone receptor positive advanced breast cancer: Applying the results from recent clinical trials into daily practice-insights, limitations, and moving forward. Am Soc Clin Oncol Educ Book. 33(e20)2013.PubMed/NCBI View Article : Google Scholar

7 

Saxton RA and Sabatini DM: mTOR signaling in growth, 379 metabolism, and disease. Cell. 168:960–976. 2017.PubMed/NCBI View Article : Google Scholar

8 

Dickler MN, Tolaney SM, Rugo HS, Cortés J, Diéras V, Patt D, Wildiers H, Frenzel M, Koustenis A and Baselga J: MONARCH 1: Results from phase II study of abemaciclib, a CDK4 and CDK6 inhibitor, as monotherpay, in patients with HR+/HER2- breast cancer, after chemotherapy for advanced disease. J Clin Oncol. 34(510)2016.

9 

Di Cristofano A, Pesce B, Cordon-Cardo C and Pandolfi PP: PTEN is essential for embryonic development and tumour suppression. Nature Genetics. 19:348–355. 1998.PubMed/NCBI View Article : Google Scholar

10 

Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, et al: Pandolfi systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 149:49–62. 2012.PubMed/NCBI View Article : Google Scholar

11 

Song MS, Salmena L and Pandolfi PP: The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol. 13:283–296. 2012.PubMed/NCBI View Article : Google Scholar

12 

Ma X and Blenis J: Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol. 10:307–318. 2009.PubMed/NCBI View Article : Google Scholar

13 

Huang J and Manning BD: A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans. 37:217–222. 2009.PubMed/NCBI View Article : Google Scholar

14 

Inoki K, Li Y, Zhu T, Wu J and Guan KL: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol. 4:648–657. 2002.PubMed/NCBI View Article : Google Scholar

15 

Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA and Cantley LC: The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 6:91–99. 2004.PubMed/NCBI View Article : Google Scholar

16 

Wilkinson KD and Hochstrasser M: Deubiquitinating enzymes. In: Ubiquitin and Biology of the Cell. Peters JM, Finley D and Harris JR (eds). Plenum Press, New York, NY, pp99-120, 1998.

17 

Everett RD, Meredith M, Orr A, Cross A, Kathoria M and Parkinson J: A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J. 16:566–577. 1997.PubMed/NCBI View Article : Google Scholar

18 

Amerik AY and Hochstrasser M: Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta. 1695:189–207. 2004.PubMed/NCBI View Article : Google Scholar

19 

Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, et al: Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 15:1486–1494. 2013.PubMed/NCBI View Article : Google Scholar

20 

Hussain S, Zhang Y and Galardy PJ: DUBs and cancer: The role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors. Cell Cycle. 8:1688–1697. 2009.PubMed/NCBI View Article : Google Scholar

21 

Zhang M, Hu C, Tong D, Xiang S, Williams K, Bai W, Li GM, Bepler G and Zhang X: Ubiquitin-specific peptidase 10 (USP10) deubiquitinates and stabilizes MutS Homolog 2 (MSH2) to regulate cellular sensitivity to DNA damage. J Biol Chem. 291:10783–10791. 2016.PubMed/NCBI View Article : Google Scholar

22 

Lin Z, Yang H, Tan C, Li J, Liu Z, Quan Q, Kong S, Ye J, Gao B and Fang D: USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation. Cell Rep. 5:1639–1649. 2013.PubMed/NCBI View Article : Google Scholar

23 

Sun J, Li T, Zhao Y, Huang L, Sun H, Wu H and Jiang X: USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN. Mol Cell Biochem. 41:1–7. 2018.PubMed/NCBI View Article : Google Scholar

24 

Lu C, Ning Z, Wang A, Chen D, Liu X, Xia T, Tekcham DS, Wang W, Li T, Liu X, et al: USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma. Cancer Lett. 436:139–148. 2018.PubMed/NCBI View Article : Google Scholar

25 

Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP and Leeuwenburgh C: Molecular inflammation: Underpinnings of aging and age-related diseases. Ageing Res Rev. 8:18–30. 2009.PubMed/NCBI View Article : Google Scholar

26 

Douglas EV, Rahul R, Sadiya SK, Mesut E and Asish KG: Plasminogen activator inhibitor-1 is a marker and a mediator of senescence. Arterioscler Thromb Vasc Biol. 37:1446–1452. 2017.PubMed/NCBI View Article : Google Scholar

27 

Shin SG, Koh SH, Woo CH and Lim JH: PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media. Acta Otolaryngol. 134:1231–1238. 2014.PubMed/NCBI View Article : Google Scholar

28 

Wei X, Li S, He J, Du H, Liu Y, Yu W, Hu H, Han L, Wang C, Li H, et al: Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling. Cell Commun Signal. 17(58)2019.PubMed/NCBI View Article : Google Scholar

29 

Bhatelia K, Singh K and Singh R: TLRs: Linking inflammation and breast cancer. Cell Signal. 26:2350–2357. 2014.PubMed/NCBI View Article : Google Scholar

30 

Jiang X and Shapiro DJ: The immune system and inflammation in breast cancer. Mol Cell Endocrinol. 382:673–682. 2014.PubMed/NCBI View Article : Google Scholar

31 

Harris RE, Casto BC and Harris ZM: Cyclooxygenase-2 and the inflammogenesis of breast cancer. World J Clin Oncol. 5:677–692. 2014.PubMed/NCBI View Article : Google Scholar

32 

Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JT, Jeffrey SS and Giaccia AJ: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 440:1222–1226. 2006.PubMed/NCBI View Article : Google Scholar

33 

Kirschmann DA, Seftor EA, Fong SFT, Nieva DR, Sullivan CM, Edwards EM, Sommer P, Csiszar K and Hendrix MJ: A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res. 62:4478–4483. 2002.PubMed/NCBI

34 

Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, et al: Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer. Proc Natl Acad Sci USA. 114:13030–13035. 2017.PubMed/NCBI View Article : Google Scholar

35 

Noguchi M, Rose DP, Earashi M and Miyazaki I: The role of fatty acids and eicosanoid inhibitors in breast carcinoma. Oncology. 52:265–271. 1995.PubMed/NCBI View Article : Google Scholar

36 

Ma YV, Lam C, Dalmia S, Gao P, Young J, Middleton K, Liu C, Xu H and You L: Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling. J Cell Biochem. 119:5665–5675. 2018.PubMed/NCBI View Article : Google Scholar

37 

Breunig C, Pahl J, Küblbeck M, Miller M, Antonelli D, Erdem N, Wirth C, Will R, Bott A, Cerwenka A and Wiemann S: MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells. Cell Death Dis. 8(e2973)2017.PubMed/NCBI View Article : Google Scholar

38 

Yu B, Gao W, Zhou H, Miao X, Chang Y, Wang L, Xu M and Ni G: Propofol induces apoptosis of breast cancer cells by downregulation of miR-24 signal pathway. Cancer Biomark. 21:513–519. 2018.PubMed/NCBI View Article : Google Scholar

39 

Yin N, Yi L, Khalid S, Ozbey U, Sabitaliyevich UY and Farooqi AA: TRAIL mediated signaling in breast cancer: Awakening guardian angel to induce apoptosis and overcome drug resistance. Adv Exp Med Biol. 1152:243–252. 2019.PubMed/NCBI View Article : Google Scholar

40 

Zhang Y, Li Y, Li H, Chen W and Liu W: Clostridium difficile toxin B recombinant protein inhibits tumor growth and induces apoptosis through inhibiting Bcl-2 expression, triggering inflammatory responses and activating C-erbB-2 and Cox-2 expression in breast cancer mouse model. Biomed Pharmacother. 101:391–398. 2018.PubMed/NCBI View Article : Google Scholar

41 

Luo J, Hu YL and Wang H: Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-κB signaling pathways in vitro. Exp Ther Med. 14:3623–3631. 2017.PubMed/NCBI View Article : Google Scholar

42 

Burstein E and Ducket CS: Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol. 15:732–737. 2003.PubMed/NCBI View Article : Google Scholar

43 

Helms S: Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev. 9:259–274. 2004.PubMed/NCBI

44 

Davydov M and Krikorian AD: Eleutherococcus senticosus (Rupr & Maxim.) Maxim. (Araliaceae) as an adaptogen: A closer look. J Ethnopharmacol. 72:345–393. 2000.PubMed/NCBI View Article : Google Scholar

45 

Lee S, Shin DS, Oh KB and Skin KH: Antibacterial compounds from leaves of Acanthopanax senticosus. Arch Pharm Res. 26:40–42. 2003.PubMed/NCBI View Article : Google Scholar

46 

Hasegawa H, Suzuki R, Nagaoka T, Tezuka Y, Kadota S and Saiki I: Prevention of growth and metastasis of murine melanoma through enhanced natural-killercytotoxicity by fatty acid conjugate of protopanaxatriol. Biol Pharm Bull. 25:861–866. 2002.PubMed/NCBI View Article : Google Scholar

47 

Kiyohara H, Hirano M, Wen XG, Matsumoto T, Sun XB and Yamada H: Characterization of an antiulcer pectic polysaccharide from leaves of Panaxginseng C.A. Meyer. Carbohydr Res. 263:89–101. 1994.PubMed/NCBI View Article : Google Scholar

48 

Schepetkin IA and Quinn MT: Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential. Int Immunopharmacol. 6:317–333. 2006.PubMed/NCBI View Article : Google Scholar

49 

Yoon TJ, Yoo YC, Kang TB, Baek YJ, Huh CS, Song SK, Lee KH, Azuma I and Kim JB: Prophylactic effect of Korean mistletoe (Viscum album coloratum) extract on tumor metastasis is mediated by enhancement of NK cell activity. Int J Immunopharmacol. 20:163–172. 1998.PubMed/NCBI View Article : Google Scholar

50 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

51 

Shin MS, Lee H, Hong HD and Shin KS: Characterization of immunostimulatory pectic polysaccharide isolated from the leaves of Diospyros kaki Tumb (Persimmon). J Funct Foods. 26:319–329. 2016.

52 

Park JY, Shin MS, Kim SN, Kim HY, Kim KH, Shin KS and Kang KS: Polysaccharides from Korean Citrus hallabong peels inhibit angiogenesis andbreast cancer cell migration. Int J Biol Macromol. 85:522–529. 2016.PubMed/NCBI View Article : Google Scholar

53 

Lee EH, Park HR, Shin MS, Cho SY, Choi HJ and Shin KS: Antitumor metastasis activity of pectic polysaccharide purified from the peels of Korean Citrus Hallabong. Carbohydr Polym. 111:72–79. 2014.PubMed/NCBI View Article : Google Scholar

54 

Xuan YH, Huang BB, Tian HS, Chi LS, Duan YM, Wang X, Zhu ZX, Cai WH, Zhu YT, Wei TM, et al: High-glucose inhibits human fibroblast cell migration in wound healing via repression of bFGF-regulating JNK phosphorylation. PLoS One. 9(e108182)2014.PubMed/NCBI View Article : Google Scholar

55 

Keum YS, Han SS, Chun KS, Park KK, Park JH, Lee SK and Surh YJ: Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat Res. 523-524:75–85. 2003.PubMed/NCBI View Article : Google Scholar

56 

Ip YT and Davis RJ: Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr Opin Cell Biol. 10:205–219. 1998.PubMed/NCBI View Article : Google Scholar

57 

Liu YY, Ge C, Tian H, Jiang JY, Zhao FY, Li H, Chen TY, Yao M and Li JJ: The transcription factor Ikaros inhibits cell proliferation by downregulating ANXA4 expression in hepatocellular carcinoma. Am J Cancer Res. 7:1285–1297. 2017.PubMed/NCBI

58 

Baeuerle PA and Baltimore D: NF-kappa B: Ten years after. Cell. 87:13–20. 1996.PubMed/NCBI View Article : Google Scholar

59 

Ahn JY, Choi IS, Shim JY, Yun EK, Yun YS, Jeong G and Song JY: The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals. Eur J Immunol. 36:37–45. 2006.PubMed/NCBI View Article : Google Scholar

60 

Kashii-Magaribuchi K, Takeuchi R, Haisa Y, Sakamoto A, Itoh A, Izawa Y, Isa M, Fukuzawa M, Murakami M and Takahashi R: Induced expression of cancer stem cell markers ALDH1A3 and Sox-2 in hierarchical reconstitution of apoptosis-resistant human breast cancer cells. Acta Histochem Cytochem. 49:149–158. 2016.PubMed/NCBI View Article : Google Scholar

61 

Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV and Boldin M: Tumor necrosis factor receptor and Fas signaling mechanisms. Ann Rev Immunol. 17:331–367. 1999.PubMed/NCBI View Article : Google Scholar

62 

Ehrhardt H, Fulda S, Schmid I, Hiscott J, Debatin KM and Jeremias I: TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene. 22:3842–3852. 2003.PubMed/NCBI View Article : Google Scholar

63 

Trauzold A, Siegmund D, Schniewind B, Sipos B, Egberts J, Zorenkov D, Emme D, Röder C, Kalthoff H and Wajant H: TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene. 25:7434–7439. 2006.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Yan Y, Zhang X, Zhao T, Xu J and Han R: Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response. Exp Ther Med 20: 229, 2020.
APA
Zhou, H., Yan, Y., Zhang, X., Zhao, T., Xu, J., & Han, R. (2020). Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response. Experimental and Therapeutic Medicine, 20, 229. https://doi.org/10.3892/etm.2020.9359
MLA
Zhou, H., Yan, Y., Zhang, X., Zhao, T., Xu, J., Han, R."Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response". Experimental and Therapeutic Medicine 20.6 (2020): 229.
Chicago
Zhou, H., Yan, Y., Zhang, X., Zhao, T., Xu, J., Han, R."Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response". Experimental and Therapeutic Medicine 20, no. 6 (2020): 229. https://doi.org/10.3892/etm.2020.9359
Copy and paste a formatted citation
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Spandidos Publications style
Zhou H, Yan Y, Zhang X, Zhao T, Xu J and Han R: Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response. Exp Ther Med 20: 229, 2020.
APA
Zhou, H., Yan, Y., Zhang, X., Zhao, T., Xu, J., & Han, R. (2020). Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response. Experimental and Therapeutic Medicine, 20, 229. https://doi.org/10.3892/etm.2020.9359
MLA
Zhou, H., Yan, Y., Zhang, X., Zhao, T., Xu, J., Han, R."Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response". Experimental and Therapeutic Medicine 20.6 (2020): 229.
Chicago
Zhou, H., Yan, Y., Zhang, X., Zhao, T., Xu, J., Han, R."Ginseng polysaccharide inhibits MDA‑MB‑231 cell proliferation by activating the inflammatory response". Experimental and Therapeutic Medicine 20, no. 6 (2020): 229. https://doi.org/10.3892/etm.2020.9359
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