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Article

Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma

  • Authors:
    • Kun Huang
    • Ningning Gao
    • Donglin Bian
    • Qixi Zhai
    • Puxu Yang
    • Yunfei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasonic Diagnosis, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Ultrasonic Diagnosis, Liaoning Province Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China
  • Article Number: 243
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    Published online on: October 22, 2020
       https://doi.org/10.3892/etm.2020.9373
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Abstract

In the present study, the recurrence rate of papillary thyroid microcarcinoma (PTMC) was assessed by analyzing postoperative follow‑up data of affected patients and its associations with BRAF V600E, clinical pathology and imaging factors were explored. A total of 506 patients with PTMC were selected who underwent surgery from January 2014 to March 2016. The maximal diameter of thyroid nodules was ≤1 cm and all patients who underwent BRAF V600E testing and evaluation for lymph node metastasis. Postoperatively, each patient was regularly followed up to detect recurrence. Categorical variables were comparatively analyzed using univariate Cox linear regression analysis to screen for protective and adverse factors influencing recurrence of PTMC. A stepwise Cox proportional hazards regression model analysis was performed to explore risk factors affecting recurrence. Among the 506 patients, 477 were followed up, 29 were lost to follow‑up and 26 patients experienced recurrence. The 5‑year recurrent rate of PTMC was 5.45%. The univariate Cox regression analysis indicated that PTMC recurrence was influenced by BRAF V600E, sex, multifocality, capsular invasion and lateral cervical lymph node metastasis (P<0.05), but not by age, tumor location on the thyroid, size, single central lymph node metastasis, distant metastasis and operative approach (P>0.05). The significant factors associated with recurrent PTMC were subjected to stepwise multivariate Cox proportional hazards regression model analysis and the results indicated that BRAF V600E, sex, multifocality and lateral cervical lymph node metastasis were independent factors influencing recurrence in patients with PTMC, with a statistically significant difference (P<0.05). In conclusion, BRAF V600E, sex, multifocality and lateral cervical lymph node metastasis are independent risk factors for recurrent PTMC.
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Copy and paste a formatted citation
Spandidos Publications style
Huang K, Gao N, Bian D, Zhai Q, Yang P and Zhang Y: Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma. Exp Ther Med 20: 243, 2020.
APA
Huang, K., Gao, N., Bian, D., Zhai, Q., Yang, P., & Zhang, Y. (2020). Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma. Experimental and Therapeutic Medicine, 20, 243. https://doi.org/10.3892/etm.2020.9373
MLA
Huang, K., Gao, N., Bian, D., Zhai, Q., Yang, P., Zhang, Y."Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma". Experimental and Therapeutic Medicine 20.6 (2020): 243.
Chicago
Huang, K., Gao, N., Bian, D., Zhai, Q., Yang, P., Zhang, Y."Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma". Experimental and Therapeutic Medicine 20, no. 6 (2020): 243. https://doi.org/10.3892/etm.2020.9373
Copy and paste a formatted citation
x
Spandidos Publications style
Huang K, Gao N, Bian D, Zhai Q, Yang P and Zhang Y: Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma. Exp Ther Med 20: 243, 2020.
APA
Huang, K., Gao, N., Bian, D., Zhai, Q., Yang, P., & Zhang, Y. (2020). Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma. Experimental and Therapeutic Medicine, 20, 243. https://doi.org/10.3892/etm.2020.9373
MLA
Huang, K., Gao, N., Bian, D., Zhai, Q., Yang, P., Zhang, Y."Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma". Experimental and Therapeutic Medicine 20.6 (2020): 243.
Chicago
Huang, K., Gao, N., Bian, D., Zhai, Q., Yang, P., Zhang, Y."Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma". Experimental and Therapeutic Medicine 20, no. 6 (2020): 243. https://doi.org/10.3892/etm.2020.9373
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