Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting

  • Authors:
    • Wenqian Zhai
    • Lieming Yang
    • Peng Sun
    • Yunfei Li
    • Jiange Han
    • Guolin Wang
  • View Affiliations / Copyright

    Affiliations: Tianjin Medical University, Tianjin 300070, P.R. China, Department of Cardiovascular Surgery, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China, Department of Anesthesiology, Tianjin Chest Hospital, Tianjin 300222, P.R. China, Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China
    Copyright: © Zhai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 250
    |
    Published online on: October 23, 2020
       https://doi.org/10.3892/etm.2020.9380
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine the effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary artery bypass grafting (OPCABG). A total of 300 patients about to receive OPCABG were randomized evenly into the control group (n=116) and study group (n=123). Intravenous dexmedetomidine pump infusion was administered to patients in the study group at a rate of 0.4 µg.kg‑1.h‑1. The control group received physiological saline at the same infusion speed. Changes in hemodynamic parameters and inflammatory indices were compared between the two groups. Hemodynamic parameters, such as the heart rate and mean arterial pressure, were lower in patients from the study group, compared with that in the control group (both P<0.05). The levels of pro‑inflammatory factors, such as interleukin (IL)‑6, tumor necrosis factor‑α and C‑reactive protein, were also reduced in the study group (P<0.05). The observed levels of IL‑10 were lower in the control group compared with that in the study group, although a statistically significant difference was not achieved. Thus, the administration of dexmedetomidine in patients undergoing OPCABG stabilized hemodynamics and reduced inflammation. The present study was registered at the Chinese Clinical Trial Registry, under the trial registration number ChiCTR‑OOC‑15005978 (2015).
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Malakar AK, Choudhury D, Halder B, Paul P, Uddin A and Chakraborty S: A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 234:16812–16823. 2019.PubMed/NCBI View Article : Google Scholar

2 

Nwaejike N, Mansha M, Bonde P and Campalani G: Myocardial revascularization by off pump coronary bypass surgery (OPCABG): A ten year review. Ulster Med J. 77:106–109. 2008.PubMed/NCBI

3 

Wang R: Effect of dexmedetomidine continuous infusion on off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 17:24–26. 2013.

4 

Zhang Q, Lu C and Liu G: Effects of dexmedetomidine hydrochloride on postoperative cognitive function in patients undergoing off-pump coronary-artery bypass grafting. Chin J Lab Diagn. 16:346–348. 2012.

5 

Weerink MAS, Struys MMRF, Hannivoort LN, Barends CRM, Absalom AR and Colin P: Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clin Pharmacokinet. 56:893–913. 2017.PubMed/NCBI View Article : Google Scholar

6 

Zhou H, Xiao W and Zhao H: The effect of dexmedetomidine on hemodynamics and stress reaction in patients undergoing cardiac valve replacement surgery. Chin J Exp Surg. 28:2230–2233. 2011.

7 

Ling Y, Sun Y and Liang Q: Effects of dexmedetomidine on hemodynamics and stress reaction in pediatric patients undergoing cardiac surgery. Shanghai Medical J. 35:96–100. 2012.

8 

Wang X and Chen H: Effect of remifentanil combined with dexmedetomidine on hemodynamics in the anesthetic of cardiac surgery. Pract Pharm Clin Rem. 16:799–801. 2013.

9 

Flanders CA, Rocke AS, Edwardson SA, Baillie JK and Walsh TS: The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: A systematic review of animal and human studies. Crit Care. 23(402)2019.PubMed/NCBI View Article : Google Scholar

10 

Portier K and Ida KK: The ASA physical status classification: What is the evidence for recommending its use in veterinary anesthesia?-A systematic review. Front Vet Sci. 5(204)2018.PubMed/NCBI View Article : Google Scholar

11 

Dong W, Chen MH, Yang YH, Zhang X, Huang MJ, Yang XJ and Wang HZ: The effect of dexmedetomidine on expressions of inflammatory factors in patients with radical resection of gastric cancer. Eur Rev Med Pharmacol Sci. 21:3510–3515. 2017.PubMed/NCBI

12 

Zhang Y, Jia S, Gao T, Zhang R, Liu Z and Wang Y: Dexmedetomidine mitigate acute lung injury by inhibiting IL-17-induced inflammatory reaction. Immunobiology. 223:32–37. 2018.PubMed/NCBI View Article : Google Scholar

13 

Gallego-Ligorit L, Vives M, Vallés-Torres J, Sanjuán-Villarreal TA, Pajares A and Iglesias M: Use of dexmedetomidine in cardiothoracic and vascular anesthesia. J Cardiothorac Vasc Anesth. 32:1426–1438. 2018.PubMed/NCBI View Article : Google Scholar

14 

Rong H, Zhao Z, Feng J, Lei Y, Wu H, Sun R, Zhang Z, Hou B, Zhang W, Sun Y, et al: The effects of dexmedetomidine pretreatment on the pro- and anti-inflammation systems after spinal cord injury in rats. Brain Behav Immun. 64:195–207. 2017.PubMed/NCBI View Article : Google Scholar

15 

Li H, Zhang X, Chen M, Chen J, Gao T and Yao S: Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades. EXCLI J. 17:302–311. 2018.PubMed/NCBI View Article : Google Scholar

16 

Cheng M, Gao T, Xi F, Cao C, Chen Y, Zhao C, Li Q and Yu W: Dexmedetomidine ameliorates muscle wasting and attenuates the alteration of hypothalamic neuropeptides and inflammation in endotoxemic rats. PLoS One. 12(e0174894)2017.PubMed/NCBI View Article : Google Scholar

17 

Ihmsen H and Saari TI: Dexmedetomidine. Pharmacokinetics and pharmacodynamics. Anaesthesist. 61:1059–1066. 2012.(In German). PubMed/NCBI View Article : Google Scholar

18 

Mo W, Li B and Tan W: Effect of dexmdetomidine on hemodynamics during induction of anesthesia in cardiac surgery. Chin J Misdiagn. 11:1604–1605. 2011.

19 

Jiao F, Chen H and Huang C: Effects of dexmedetomidine on hemodynamics and stress response in the perioperative period of infant cardiac surgery. Modern Hospital. 14:45–47. 2014.

20 

Xue Z, Wang S and Liu A: Effects of dexmedetomidine on hemodynamics during induction of anesthesia in patients with atrial fibrillation with rapid ventricular rate undergoing noncardiac surgery. Chinese J Anesthesiol. 34:1452–1454. 2014.

21 

Kawazoe Y, Miyamoto K, Morimoto T, Yamamoto T, Fuke A, Hashimoto A, Koami H, Beppu S, Katayama Y, Itoh M, et al: Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: A randomized clinical trial. JAMA. 317:1321–1328. 2017.PubMed/NCBI View Article : Google Scholar

22 

Mato M, Pérez A, Otero J and Torres LM: Dexmedetomidine, a promising drug. Rev Esp Anestesiol Reanim. 49:407–420. 2002.(In Spanish). PubMed/NCBI

23 

Afonso J and Reis F: Dexmedetomidine: Current role in anesthesia and intensive care. Rev Bras Anestesiol. 62:118–133. 2012.PubMed/NCBI View Article : Google Scholar

24 

Arcangeli A, D'Alo C and Gaspari R: Dexmedetomidine use in general anaesthesia. Curr Drug Targets. 10:687–695. 2009.PubMed/NCBI View Article : Google Scholar

25 

Triltsch AE, Welte M, von Homeyer P, Grosse J, Genähr A, Moshirzadeh M, Sidiropoulos A, Konertz W, Kox WJ and Spies CD: Bispectral index-guided sedation with dexmedetomidine in intensive care: A prospective, randomized, double blind, placebo-controlled phase II study. Crit Care Med. 30:1007–1014. 2002.PubMed/NCBI View Article : Google Scholar

26 

Sommer C, Leinders M and Üçeyler N: Inflammation in the pathophysiology of neuropathic pain. Pain. 159:595–602. 2018.PubMed/NCBI View Article : Google Scholar

27 

Marshall JC: SIRS and MODS: What is their relevance to the science and practice of intensive care? Shock. 14:586–589. 2000.PubMed/NCBI

28 

Deng Y, Tan F, Gan X, Li X, Ge M, Gong C, Hei Z, Zhu Q and Zhou S: Perioperative application of dexmedetomidine for postoperative systemic inflammatory response syndrome in patients undergoing percutaneous nephrolithotomy lithotripsy: Results of a randomised controlled trial. BMJ Open. 8(e019008)2018.PubMed/NCBI View Article : Google Scholar

29 

Seyrek M, Binbay M, Yuruk E, Akman T, Aslan R, Yazici O, Berberoglu Y and Muslumanoglu AY: Perioperative prophylaxis for percutaneous nephrolithotomy: Randomized study concerning the drug and dosage. J Endourol. 26:1431–1436. 2012.PubMed/NCBI View Article : Google Scholar

30 

Ueki M, Kawasaki T, Habe K, Hamada K, Kawasaki C and Sata T: The effects of dexmedetomidine on inflammatory mediators after cardiopulmonary bypass. Anaesthesia. 69:693–700. 2014.PubMed/NCBI View Article : Google Scholar

31 

Li B, Li Y, Tian S, Wang H, Wu H, Zhang A and Gao C: Anti-inflammatory effects of perioperative dexmedetomidine administered as an adjunct to general anesthesia: A Meta-analysis. Sci Rep. 5(12342)2015.PubMed/NCBI View Article : Google Scholar

32 

Sukegawa S, Higuchi H, Inoue M, Nagatsuka H, Maeda S and Miyawaki T: Locally injected dexmedetomidine inhibits carrageenin-induced inflammatory responses in the injected region. Anesth Analg. 118:473–480. 2014.PubMed/NCBI View Article : Google Scholar

33 

Taniguchi T, Kidani Y, Kanakura H, Takemoto Y and Yamamoto K: Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats. Crit Care Med. 32:1322–1326. 2004.PubMed/NCBI View Article : Google Scholar

34 

Kawasaki T, Kawasaki C, Ueki M, Hamada K, Habe K and Sata T: Dexmedetomidine suppresses proinflammatory mediator production in human whole blood in vitro. J Trauma Acute Care Surg. 74:1370–1375. 2013.PubMed/NCBI View Article : Google Scholar

35 

Yuan X: Effect of laparoscopic radical resection of colorectal cancer on serum CRP, IL-6 and IL-10 expression. J Pract Clin Med. 18:47–48. 2014.

36 

Xu F, Yang CX and Deng SZ: Progress of clinical application of dexmedetomidine in perioperative period. Int J Anesthesiol Resuscit. 32:336–340. 2011.

37 

Tanskanen PE, Kyttä JV, Randell TT and Aantaa RE: Dexmedetomidineas an anesthetic adjuvant in patients undergoing intracranialtumor surgery: A double-blind, randomized and placebo-controlled study. Br J Anaesth. 97:658–665. 2006.PubMed/NCBI View Article : Google Scholar

38 

Geng F, Yu L and Long D: The effect of dexmedetomidine on postoperative cognitive function and inflammatory response of elderly patients undergoing laparoscopic radical gastrectomy. J Prev Med PLA. 5:146–147, 149. 2019.

39 

Yang D and Hong JH: Dexmedetomidine modulateshistamine-induced Ca2+ signaling and pro-inflammatorycytokine expression. Korean J Physiol Pharmacol. 19:413–420. 2015.PubMed/NCBI View Article : Google Scholar

40 

Chen S, Hua F, Lu J, Jiang Y, Tang Y, Tao L, Zou B and Wu Q: Effect of dexmedetomidine on myocardial ischemia-reperfusion injury. Int J Clin Exp Med. 8:21166–21172. 2015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhai W, Yang L, Sun P, Li Y, Han J and Wang G: Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting. Exp Ther Med 20: 250, 2020.
APA
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., & Wang, G. (2020). Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting. Experimental and Therapeutic Medicine, 20, 250. https://doi.org/10.3892/etm.2020.9380
MLA
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., Wang, G."Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting". Experimental and Therapeutic Medicine 20.6 (2020): 250.
Chicago
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., Wang, G."Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting". Experimental and Therapeutic Medicine 20, no. 6 (2020): 250. https://doi.org/10.3892/etm.2020.9380
Copy and paste a formatted citation
x
Spandidos Publications style
Zhai W, Yang L, Sun P, Li Y, Han J and Wang G: Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting. Exp Ther Med 20: 250, 2020.
APA
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., & Wang, G. (2020). Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting. Experimental and Therapeutic Medicine, 20, 250. https://doi.org/10.3892/etm.2020.9380
MLA
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., Wang, G."Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting". Experimental and Therapeutic Medicine 20.6 (2020): 250.
Chicago
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., Wang, G."Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting". Experimental and Therapeutic Medicine 20, no. 6 (2020): 250. https://doi.org/10.3892/etm.2020.9380
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team