Open Access

Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting

  • Authors:
    • Wenqian Zhai
    • Lieming Yang
    • Peng Sun
    • Yunfei Li
    • Jiange Han
    • Guolin Wang
  • View Affiliations

  • Published online on: October 23, 2020     https://doi.org/10.3892/etm.2020.9380
  • Article Number: 250
  • Copyright: © Zhai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to determine the effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary artery bypass grafting (OPCABG). A total of 300 patients about to receive OPCABG were randomized evenly into the control group (n=116) and study group (n=123). Intravenous dexmedetomidine pump infusion was administered to patients in the study group at a rate of 0.4 µg.kg‑1.h‑1. The control group received physiological saline at the same infusion speed. Changes in hemodynamic parameters and inflammatory indices were compared between the two groups. Hemodynamic parameters, such as the heart rate and mean arterial pressure, were lower in patients from the study group, compared with that in the control group (both P<0.05). The levels of pro‑inflammatory factors, such as interleukin (IL)‑6, tumor necrosis factor‑α and C‑reactive protein, were also reduced in the study group (P<0.05). The observed levels of IL‑10 were lower in the control group compared with that in the study group, although a statistically significant difference was not achieved. Thus, the administration of dexmedetomidine in patients undergoing OPCABG stabilized hemodynamics and reduced inflammation. The present study was registered at the Chinese Clinical Trial Registry, under the trial registration number ChiCTR‑OOC‑15005978 (2015).
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December-2020
Volume 20 Issue 6

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Spandidos Publications style
Zhai W, Yang L, Sun P, Li Y, Han J and Wang G: Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting. Exp Ther Med 20: 250, 2020
APA
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., & Wang, G. (2020). Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting. Experimental and Therapeutic Medicine, 20, 250. https://doi.org/10.3892/etm.2020.9380
MLA
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., Wang, G."Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting". Experimental and Therapeutic Medicine 20.6 (2020): 250.
Chicago
Zhai, W., Yang, L., Sun, P., Li, Y., Han, J., Wang, G."Effect of dexmedetomidine on hemodynamic changes and inflammatory responses in patients undergoing off‑pump coronary‑artery bypass grafting". Experimental and Therapeutic Medicine 20, no. 6 (2020): 250. https://doi.org/10.3892/etm.2020.9380