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Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling

  • Authors:
    • Yuxiang Li
    • Yuxia Gao
    • Bing Liang
    • Wenbo Nie
    • Lijing Zhao
    • Lisheng Wang
  • View Affiliations / Copyright

    Affiliations: School of Nursing, Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 262
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    Published online on: October 27, 2020
       https://doi.org/10.3892/etm.2020.9392
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Abstract

Targeting multiple signaling pathways is a potential novel therapeutic strategy for the treatment of leukemias. Leukemia cells express high levels of sphingosine kinase 1 (Sphk1) and sirtuin 1 (SIRT1). However, to the best of our knowledge, their interaction and potential synergistic inhibitory effects on the growth and survival of leukemia cells have not been investigated. The present study revealed the role of the Sphk1/S1P/SIRT1 axis in K562, KCL22 and TF1 cells and hypothesized that the inhibition of Sphk1 and SIRT1 had synergistic effects on the growth and survival of leukemia cells. Cell viability was tested using a Cell Counting Kit‑8 assay and cell colony forming assay. Cell apoptosis was detected using Annexin V‑APC/PI staining. The stages of the cell cycle were measured using PI staining. Protein levels were measured by western blotting. Treatment of leukemia cells with S1P resulted in the upregulation of SIRT1 expression, whereas inhibition of Sphk1 induced SIRT1 downregulation in leukemia cells. Both SKI‑II and EX527 actively suppressed growth, blocked cell cycle progression and induced apoptosis of leukemia cells. Furthermore, inhibition of Sphk1 and SIRT1 exhibited suppressive effects on the growth and survival of leukemia cells. Notably, the inhibition of Sphk1 and SIRT1 suppressed cell growth and induced apoptosis of T‑315I mutation‑harboring cells. Additionally, treatment with SKI‑II and EX527 suppressed the ERK and STAT5 pathways in leukemia cells. These data indicated that targeting the Sphk1/S1P/SIRT1 axis may be a novel therapeutic strategy for the treatment of leukemia.
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1 

Kumari A, Brendel C, Hochhaus A, Neubauer A and Burchert A: Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib. Blood. 119:530–539. 2012.PubMed/NCBI View Article : Google Scholar

2 

O'Hare T, Deininger MW, Eide CA, Clackson T and Druker BJ: Targeting the BCR-ABL signaling pathway in therapy-resistant Philadelphia chromosome-positive leukemia. Clin Cancer Res. 17:212–221. 2011.PubMed/NCBI View Article : Google Scholar

3 

Corbin AS, Agarwal A, Loriaux M, Cortes J, Deininger MW and Druker BJ: Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest. 121:396–409. 2011.PubMed/NCBI View Article : Google Scholar

4 

Cilloni D and Saglio G: Molecular pathways: BCR-ABL. Clin Cancer Res. 18:930–937. 2012.PubMed/NCBI View Article : Google Scholar

5 

Sattler M and Griffin JD: Molecular mechanisms of transformation by the BCR-ABL oncogene. Semin Hematol. 40 (Suppl 2):S4–S10. 2003.PubMed/NCBI View Article : Google Scholar

6 

Sinclair A, Latif AL and Holyoake TL: Targeting survival pathways in chronic myeloid leukemia stem cells. Br J Pharmacol. 169:1693–1707. 2013.PubMed/NCBI View Article : Google Scholar

7 

Liu Q, Luo Q, Halim A and Song G: Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer. Cancer Lett. 401:39–45. 2017.PubMed/NCBI View Article : Google Scholar

8 

Tang X, Benesch MG and Brindley DN: Lipid phosphate phosphatases and their roles in mammalian physiology and pathology. J Lipid Res. 56:2048–2060. 2015.PubMed/NCBI View Article : Google Scholar

9 

Patmanathan SN, Wang W, Yap LF, Herr DR and Paterson IC: Mechanisms of sphingosine 1-phosphate receptor signalling in cancer. Cell Signal. 34:66–75. 2017.PubMed/NCBI View Article : Google Scholar

10 

Tabasinezhad M, Samadi N, Ghanbari P, Mohseni M, Saei AA, Sharifi S, Saeedi N and Pourhassan A: Sphingosin 1-phosphate contributes in tumor progression. J Cancer Res Ther. 9:556–563. 2013.PubMed/NCBI View Article : Google Scholar

11 

Nagahashi M, Takabe K, Terracina KP, Soma D, Hirose Y, Kobayashi T, Matsuda Y and Wakai T: Sphingosine-1-phosphate transporters as targets for cancer therapy. Biomed Res Int. 2014(651727)2014.PubMed/NCBI View Article : Google Scholar

12 

Mendelson K, Evans T and Hla T: Sphingosine 1-phosphate signalling. Development. 141:5–9. 2014.PubMed/NCBI View Article : Google Scholar

13 

Gao Z, Wang H, Xiao FJ, Shi XF, Zhang YK, Xu QQ, Zhang XY, Ha XQ and Wang LS: SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells. Int J Biochem Cell Biol. 74:152–160. 2016.PubMed/NCBI View Article : Google Scholar

14 

Li QF, Wu CT, Guo Q, Wang H and Wang LS: Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. Biochem Biophys Res Commun. 371:159–162. 2008.PubMed/NCBI View Article : Google Scholar

15 

Evangelisti C, Evangelisti C, Buontempo F, Lonetti A, Orsini E, Chiarini F, Barata JT, Pyne S, Pyne NJ and Martelli AM: Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. Leukemia. 30:2142–2151. 2016.PubMed/NCBI View Article : Google Scholar

16 

Li QF, Huang WR, Duan HF, Wang H, Wu CT and Wang LS: Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells. Oncogene. 26:7904–7908. 2007.PubMed/NCBI View Article : Google Scholar

17 

Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, et al: Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 117:5941–5952. 2011.PubMed/NCBI View Article : Google Scholar

18 

Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM and Ogretmen B: Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem. 282:10922–10934. 2007.PubMed/NCBI View Article : Google Scholar

19 

Ricci C, Onida F, Servida F, Radaelli F, Saporiti G, Todoerti K, Deliliers GL and Ghidoni R: In vitro anti-leukaemia activity of sphingosine kinase inhibitor. Br J Haematol. 144:350–357. 2009.PubMed/NCBI View Article : Google Scholar

20 

Marfe G, Di Stefano C, Gambacurta A, Ottone T, Martini V, Abruzzese E, Mologni L, Sinibaldi-Salimei P, de Fabritis P, Gambacorti-Passerini C, et al: Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells. Exp Hematol. 39:653–665. 2011.PubMed/NCBI View Article : Google Scholar

21 

Powell JA, Lewis AC, Zhu W, Toubia J, Pitman MR, Wallington-Beddoe CT, Moretti PA, Iarossi D, Samaraweera SE, Cummings N, et al: Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. Blood. 129:771–782. 2017.PubMed/NCBI View Article : Google Scholar

22 

Sobue S, Nemoto S, Murakami M, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Nakamura M, et al: Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: Relevance as a marker for daunorubicin sensitivity of leukemia cells. Int J Hematol. 87:266–275. 2008.PubMed/NCBI View Article : Google Scholar

23 

Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK and McCall CE: Sirtuins link inflammation and metabolism. J Immunol Res. 2016(8167273)2016.PubMed/NCBI View Article : Google Scholar

24 

Roth M, Wang Z and Chen WY: Sirtuins in hematological aging and malignancy. Crit Rev Oncog. 18:531–547. 2013.PubMed/NCBI View Article : Google Scholar

25 

Li L, Osdal T, Ho Y, Chun S, McDonald T, Agarwal P, Lin A, Chu S, Qi J, Li L, et al: SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells. Cell Stem Cell. 15:431–446. 2014.PubMed/NCBI View Article : Google Scholar

26 

Zhou L, Wang Q, Chen X, Fu L, Zhang X, Wang L, Deng A, Li D, Liu J, Lv N, et al: AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia. Exp Hematol. 46:62–69. 2017.PubMed/NCBI View Article : Google Scholar

27 

Li L, Wang L, Li L, Wang Z, Ho Y, McDonald T, Holyoake TL, Chen W and Bhatia R: Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell. 21:266–281. 2012.PubMed/NCBI View Article : Google Scholar

28 

Li L and Bhatia R: Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells. Curr Opin Hematol. 22:324–329. 2015.PubMed/NCBI View Article : Google Scholar

29 

Giusto K, Patki M, Koya J, Ashby CR Jr, Munnangi S, Patel K and Reznik SE: A vaginal nanoformulation of a SphK inhibitor attenuates lipopolysaccharide-induced preterm birth in mice. Nanomedicine (Lond). 14:2835–2851. 2019.PubMed/NCBI View Article : Google Scholar

30 

Wang T, Li X and Sun SL: EX527, a Sirt-1 inhibitor, induces apoptosis in glioma via activating the p53 signaling pathway. Anticancer Drugs. 31:19–26. 2020.PubMed/NCBI View Article : Google Scholar

31 

Peters GJ: From ‘targeted therapy’ to targeted therapy. Anticancer Res. 39:3341–3345. 2019.PubMed/NCBI View Article : Google Scholar

32 

Bhalla S, Tremblay D and Mascarenhas J: Discontinuing tyrosine kinase inhibitor therapy in chronic myelogenous leukemia: Current understanding and future directions. Clin Lymphoma Myeloma Leuk. 16:488–494. 2016.PubMed/NCBI View Article : Google Scholar

33 

Holyoake TL and Vetrie D: The chronic myeloid leukemia stem cell: Stemming the tide of persistence. Blood. 129:1595–1606. 2017.PubMed/NCBI View Article : Google Scholar

34 

Gao Y, Gao F, Chen K, Tian ML and Zhao DL: Sphingosine kinase 1 as an anticancer therapeutic target. Drug Des Devel Ther. 9:3239–3245. 2015.PubMed/NCBI View Article : Google Scholar

35 

Wallington-Beddoe CT, Bradstock KF and Bendall LJ: Oncogenic properties of sphingosine kinases in haematological malignancies. Br J Haematol. 161:623–638. 2013.PubMed/NCBI View Article : Google Scholar

36 

Shida D, Takabe K, Kapitonov D, Milstien S and Spiegel S: Targeting SphK1 as a new strategy against cancer. Curr Drug Targets. 9:662–673. 2008.PubMed/NCBI View Article : Google Scholar

37 

Xie Z, Liu H and Geng M: Targeting sphingosine-1-phosphate signaling for cancer therapy. Sci China Life Sci. 60:585–600. 2017.PubMed/NCBI View Article : Google Scholar

38 

Qiu G, Li X, Che X, Wei C, He S, Lu J, Jia Z, Pang K and Fan L: SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment. FEBS Lett. 589:2034–2042. 2015.PubMed/NCBI View Article : Google Scholar

39 

Wang W, Zhang J, Li Y, Yang X, He Y, Li T, Ren F, Zhang J and Lin R: Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1. Cancer Lett. 356:791–799. 2015.PubMed/NCBI View Article : Google Scholar

40 

Yang L, Weng W, Sun ZX, Fu XJ, Ma J and Zhuang WF: SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo. Biochem Biophys Res Commun. 460:903–908. 2015.PubMed/NCBI View Article : Google Scholar

41 

Braun TP, Eide CA and Druker BJ: Response and resistance to BCR-ABL1-targeted therapies. Cancer Cell. 37:530–542. 2020.PubMed/NCBI View Article : Google Scholar

42 

Holtz MS, Forman SJ and Bhatia R: Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli. Leukemia. 19:1034–1041. 2005.PubMed/NCBI View Article : Google Scholar

43 

Roche-Lestienne C and Preudhomme C: Mutations in the ABL kinase domain pre-exist the onset of imatinib treatment. Semin Hematol. 40 (Suppl 2):S80–S82. 2003.PubMed/NCBI View Article : Google Scholar

44 

Zhang L, Wang X, Bullock AJ, Callea M, Shah H, Song J, Moreno K, Visentin B, Deutschman D, Alsop DC, et al: Anti-S1P antibody as a novel therapeutic strategy for VEGFR TKI-resistant renal cancer. Clin Cancer Res. 21:1925–1934. 2015.PubMed/NCBI View Article : Google Scholar

45 

Sun J, Li G, Liu Y, Ma M, Song K, Li H, Zhu D, Tang X, Kong J and Yuan X: Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma. Neoplasia. 22:33–46. 2020.PubMed/NCBI View Article : Google Scholar

46 

Kaymaz BT, Selvi N, Gündüz C, Aktan C, Dalmızrak A, Saydam G and Kosova B: Repression of STAT3, STAT5A, and STAT5B expressions in chronic myelogenous leukemia cell line K-562 with unmodified or chemically modified siRNAs and induction of apoptosis. Ann Hematol. 92:151–162. 2013.PubMed/NCBI View Article : Google Scholar

47 

Chorzalska A, Ahsan N, Rao RSP, Roder K, Yu X, Morgan J, Tepper A, Hines S, Zhang P, Treaba DO, et al: Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-κB pathways in a model of chronic myeloid leukemia. Mol Oncol. 12:630–647. 2018.PubMed/NCBI View Article : Google Scholar

48 

Schafranek L, Nievergall E, Powell JA, Hiwase DK, Leclercq T, Hughes TP and White DL: Sustained inhibition of STAT5, but not JAK2, is essential for TKI-induced cell death in chronic myeloid leukemia. Leukemia. 29:76–85. 2015.PubMed/NCBI View Article : Google Scholar

49 

Nambu T, Araki N, Nakagawa A, Kuniyasu A, Kawaguchi T, Hamada A and Saito H: Contribution of BCR-ABL-independent activation of ERK1/2 to acquired imatinib resistance in K562 chronic myeloid leukemia cells. Cancer Sci. 101:137–142. 2010.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Gao Y, Liang B, Nie W, Zhao L and Wang L: Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling. Exp Ther Med 20: 262, 2020.
APA
Li, Y., Gao, Y., Liang, B., Nie, W., Zhao, L., & Wang, L. (2020). Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling. Experimental and Therapeutic Medicine, 20, 262. https://doi.org/10.3892/etm.2020.9392
MLA
Li, Y., Gao, Y., Liang, B., Nie, W., Zhao, L., Wang, L."Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling". Experimental and Therapeutic Medicine 20.6 (2020): 262.
Chicago
Li, Y., Gao, Y., Liang, B., Nie, W., Zhao, L., Wang, L."Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling". Experimental and Therapeutic Medicine 20, no. 6 (2020): 262. https://doi.org/10.3892/etm.2020.9392
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Gao Y, Liang B, Nie W, Zhao L and Wang L: Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling. Exp Ther Med 20: 262, 2020.
APA
Li, Y., Gao, Y., Liang, B., Nie, W., Zhao, L., & Wang, L. (2020). Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling. Experimental and Therapeutic Medicine, 20, 262. https://doi.org/10.3892/etm.2020.9392
MLA
Li, Y., Gao, Y., Liang, B., Nie, W., Zhao, L., Wang, L."Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling". Experimental and Therapeutic Medicine 20.6 (2020): 262.
Chicago
Li, Y., Gao, Y., Liang, B., Nie, W., Zhao, L., Wang, L."Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling". Experimental and Therapeutic Medicine 20, no. 6 (2020): 262. https://doi.org/10.3892/etm.2020.9392
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