Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses: A meta‑analysis
- Xiya Zhang
- Xuan Meng
- Ting Dou
- Hui Sun
Affiliations: Department of Special Inspection, Shandong Qingdao Hospital of Integrated Traditional and Western Medicine, Qingdao, Shandong 266002, P.R. China, Department of Ultrasound, Qingdao Fuwai Cardiovascular Hospital, Qingdao, Shandong 266021, P.R. China, Department of Ultrasound Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China, Department of Special Inspection, Qingdao Women and Children's Hospital, Qingdao, Shandong 266000, P.R. China
- Published online on: October 27, 2020 https://doi.org/10.3892/etm.2020.9395
Copyright: © Zhang
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Transvaginal ultrasound (TVUS) is a standard imaging modality for differentiating patients with benign or malignant suspected adnexal mass. To date, numerous studies have assessed the diagnostic accuracy of TVUS in various settings but with variable results. Therefore, the purpose of the present study was to perform a meta‑analysis to evaluate the diagnostic accuracy of TVUS for the differentiation of adnexal masses. An electronic search in the Medline, Scopus, Cochrane and Embase databases from inception till November 2019 was carried out. Meta‑analysis was performed to obtain pooled sensitivity and specificity of TVUS to distinguish malignant from benign adnexal masses. The quality assessment of diagnostic accuracy studies‑2 tool was used to assess the quality of trials. A total of 41 studies with 18,391 patients were included. The pooled sensitivity and specificity of TVUS was 92% (95% CI: 90‑94%) and 89% (95% CI: 85‑92%), respectively. The area under the receiver operating characteristic curve was 0.96 (95% CI: 0.84‑1.00). There was considerable heterogeneity with a statistically significant chi‑square test (P<0.001) and I2 of 99%. Meta‑regression results indicated that index test standards, patient selection bias and study design were potential sources of heterogeneity (P<0.05). The funnel plot was symmetrical and low publication bias was confirmed by an insignificant Deek's test (P=0.90). The present systematic review and meta‑analysis indicated that TVUS is useful in differentiating between benign and malignant tumours among patients with suspected adnexal mass with high sensitivity and specificity.