Open Access

Endoplasmic reticulum stress serves an important role in cardiac ischemia/reperfusion injury (Review)

  • Authors:
    • Yongxue Ruan
    • Jingjing Zeng
    • Qike Jin
    • Maoping Chu
    • Kangting Ji
    • Zhongyu Wang
    • Lei Li
  • View Affiliations

  • Published online on: October 27, 2020     https://doi.org/10.3892/etm.2020.9398
  • Article Number: 268
  • Copyright: © Ruan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although acute myocardial infarction is one of the most common fatal diseases worldwide, the understanding of its underlying pathogenesis continues to develop. Myocardial ischemia/reperfusion (I/R) can restore myocardial oxygen and nutrient supply. However, a large number of studies have demonstrated that recovery of blood perfusion after acute ischemia causes reperfusion injury to the heart. With progress made in the understanding of the underlying mechanisms of myocardial I/R and oxidative stress, a novel area of research that merits greater study has been identified, that of I/R‑induced endoplasmic reticulum (ER) stress (ERS). Cardiac I/R can alter the function of the ER, leading to the accumulation of unfolded/misfolded proteins. The resulting ERS then induces the activation of signal transduction pathways, which in turn contribute to the development of I/R injury. The mechanism of I/R injury, and the causal relationship between I/R and ERS are reviewed in the present article.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Ruan Y, Zeng J, Jin Q, Chu M, Ji K, Wang Z and Li L: Endoplasmic reticulum stress serves an important role in cardiac ischemia/reperfusion injury (Review). Exp Ther Med 20: 268, 2020
APA
Ruan, Y., Zeng, J., Jin, Q., Chu, M., Ji, K., Wang, Z., & Li, L. (2020). Endoplasmic reticulum stress serves an important role in cardiac ischemia/reperfusion injury (Review). Experimental and Therapeutic Medicine, 20, 268. https://doi.org/10.3892/etm.2020.9398
MLA
Ruan, Y., Zeng, J., Jin, Q., Chu, M., Ji, K., Wang, Z., Li, L."Endoplasmic reticulum stress serves an important role in cardiac ischemia/reperfusion injury (Review)". Experimental and Therapeutic Medicine 20.6 (2020): 268.
Chicago
Ruan, Y., Zeng, J., Jin, Q., Chu, M., Ji, K., Wang, Z., Li, L."Endoplasmic reticulum stress serves an important role in cardiac ischemia/reperfusion injury (Review)". Experimental and Therapeutic Medicine 20, no. 6 (2020): 268. https://doi.org/10.3892/etm.2020.9398