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Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10 years

  • Authors:
    • Xiufen Wang
    • Changrui Ding
    • Yulong Xu
    • Haomiao Yu
    • Songdi Zhang
    • Cuiyun Yang
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, The First Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161041, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 281
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    Published online on: October 27, 2020
       https://doi.org/10.3892/etm.2020.9411
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Abstract

This study analyzed the infection of superficial mycosis and the relationship between the distribution characteristics of pathogenic fungi and age, time and sex in Northeast China in the past 10 years. We would like to provide a theoretical basis for the diagnosis and treatment of related diseases. From December 2008 to December 2018, 5,374 superficial mycoses from Northeast China were selected. The fungal species were identified by fungal microscopy, fungal culture, and species identification. Besides, the relationship between sex, age, time and the distribution of superficial mycosis and pathogenic fungi was analyzed. Among the 5,374 patients, the top three infections were tinea pedis (n=1,538, 28.62%), tinea cruris (n=1,018, 18.94%) and tinea corporis (n=938, 17.45%). The top three pathogens were Trichophyton rubrum (n=2,849, 48.65%), Trichophyton mentagrophytes (n=947, 16.14%) and Candida spp. (n=804, 13.70%). The main pathogenic fungi were dermatophytes. The age group with the highest incidence of tinea capitis was children (n=372, 6.92%). The highest incidence rate of tinea pedis was in 31‑69‑year adults (n=905, 16.84%); Malassezia mainly affects young people aged 15‑30. Yeast and mold mostly invade the elderly patients >60 years old. The incidence of tinea cruris, tinea pedis and tinea corporis in male patients was higher than that in female patients. The incidence of onychomycosis in female patients was higher than that in male patients (P<0.05). The isolation rate of Candida, Mold, Microsporum canis, Malassezia and Sporothrix increased year by year, while that of Trichophyton rubrum, Trichophyton mentagrophyte, Trichophyton schoenleinii and Epidermophyton floccosum decreased. From December 2008 to December 2018, dermatophytes were the main pathogens of superficial mycosis in Northeast China. The distribution of disease species and pathogenic fungi varied in different gender, age and time.
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1 

Feng W, Chen C, Mo S, Qi C, Gong J, Li XN, Zhou Q, Zhou Y, Li D, Lai Y, et al: Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus. Phytochemistry. 164:184–191. 2019.PubMed/NCBI View Article : Google Scholar

2 

Bezshapochny SB, Zachepilo SV, Polyanskaya VP, Bobrova NA and Fedorchenko VI: Opportunistic mycoses of ENT organs. Part 1. Vestn Otorinolaringol. 83:67–71. 2018.PubMed/NCBI View Article : Google Scholar : (In Russian).

3 

Lao M, Wang X, Ding M, Yang Z, Chen H, Liang L, Zhan Z and Chen D: Invasive fungal disease in patients with systemic lupus erythematosus from Southern China: A retrospective study. Lupus. 28:77–85. 2019.PubMed/NCBI View Article : Google Scholar

4 

Upadhyay V, Kumar A, Singh AK and Pandey J: Epidemiological characterization of dermatophytes at a tertiary care hospital in Eastern Uttar Pradesh, India. Curr Med Mycol. 5:1–6. 2019.PubMed/NCBI View Article : Google Scholar

5 

Moriello KA: Decontamination of 70 foster family homes exposed to Microsporum canis infected cats: A retrospective study. Vet Dermatol. 30:178–e55. 2019.PubMed/NCBI View Article : Google Scholar

6 

Hilmioğlu-Polat S, Seyedmousavi S, Ilkit M, Hedayati MT, Inci R, Tumbay E and Denning DW: Estimated burden of serious human fungal diseases in Turkey. Mycoses. 62:22–31. 2019.PubMed/NCBI View Article : Google Scholar

7 

Alvarez-Moreno CA and Combariza JF: Risk of invasive fungal infections during hospital construction: How to minimize its impact in immunocompromised patients. Curr Opin Infect Dis. 32:322–329. 2019.PubMed/NCBI View Article : Google Scholar

8 

Rouzaud C, Chosidow O, Brocard A, Fraitag S, Scemla A, Anglicheau D, Bouaziz JD, Dupin N, Bougnoux ME, Hay R, et al: Severe dermatophytosis in solid organ transplant recipients: A French retrospective series and literature review. Transpl Infect Dis: Feb 20, 2018 (Epub ahead of print). doi: 10.1111/tid.12799.

9 

Deptuła A, Trejnowska E, Dubiel G, Żukowski M, Misiewska-Kaczur A, Ozorowski T and Hryniewicz W: Prevalence of healthcare-associated infections in Polish adult intensive care units: Summary data from the ECDC European Point Prevalence Survey of hospital-associated infections and antimicrobial use in Poland 2012-2014. J Hosp Infect. 96:145–150. 2017.PubMed/NCBI View Article : Google Scholar

10 

Nenoff P, Verma SB, Vasani R, Burmester A, Hipler UC, Wittig F, Krüger C, Nenoff K, Wiegand C, Saraswat A, et al: The current Indian epidemic of superficial dermatophytosis due to Trichophyton mentagrophytes - A molecular study. Mycoses. 62:336–356. 2019.PubMed/NCBI View Article : Google Scholar

11 

Otašević S, Momčilović S, Golubović M, Ignjatović A, Rančić N, Đorđević M, Ranđelović M, Hay R and Arsić-Arsenijević V: Species distribution and epidemiological characteristics of superficial fungal infections in Southeastern Serbia. Mycoses. 62:458–465. 2019.PubMed/NCBI View Article : Google Scholar

12 

Dainton C and Chu CH: A narrative review of dermatologic protocols for primary care medical service trips in Latin America and the Caribbean. Int J Dermatol. 56:1425–143. 2017.PubMed/NCBI View Article : Google Scholar

13 

Singh S, Ehsani-Chimeh N, Kornmehl H and Armstrong AW: Quality of life among dermatology patients: A systematic review of investigations using qualitative methods. G Ital Dermatol Venereol. 154:72–78. 2019.PubMed/NCBI View Article : Google Scholar

14 

Nilsson K, Friberg M, Rollman O and Tano E: Impact of prolonged storage of clinical samples at 4˚C on the recovery of dermatophytes by culture or PCR analysis. J Mycol Med. 29:1–6. 2019.PubMed/NCBI View Article : Google Scholar

15 

Leung AKC, Leong KF and Lam JM: Tinea imbricata: An overview. Curr Pediatr Rev. 15:170–174. 2019.PubMed/NCBI View Article : Google Scholar

16 

Farag AGA, Hammam MA, Ibrahem RA, Mahfouz RZ, Elnaidany NF, Qutubuddin M and Tolba RRE: Epidemiology of dermatophyte infections among school children in Menoufia Governorate, Egypt. Mycoses. 61:321–325. 2018.PubMed/NCBI View Article : Google Scholar

17 

Gawdzik A, Nowogrodzka K, Hryncewicz-Gwóźdź A, Maj J, Szepietowski J and Jankowska-Konsur A: Epidemiology of dermatomycoses in southwest Poland. Postepy Dermatol Alergol. 36:604–608. 2019.PubMed/NCBI View Article : Google Scholar

18 

de Albuquerque Maranhão FC, Oliveira-Júnior JB, Dos Santos Araújo MA and Silva DMW: Mycoses in northeastern Brazil: Epidemiology and prevalence of fungal species in 8 years of retrospective analysis in Alagoas. Braz J Microbiol. 50:969–978. 2019.PubMed/NCBI View Article : Google Scholar

19 

Antuori A, Fernández G, Fernández A, Alcaide M, Boada A, Bielsa MI, Romaní N and Matas L: Epidemiology of dermatophytic infections between 2008 and 2017 in Barcelona, Spain. Enferm Infecc Microbiol Clin. 37:642–647. 2019.PubMed/NCBI View Article : Google Scholar

20 

Sen S, Borah SN, Kandimalla R, Bora A and Deka S: Efficacy of a rhamnolipid biosurfactant to inhibit Trichophyton rubrum in vitro and in a mice model of dermatophytosis. Exp Dermatol. 28:601–608. 2019.PubMed/NCBI View Article : Google Scholar

21 

Bitencourt TA, Oliveira FB, Sanches PR, Rossi A and Martinez-Rossi NM: The prp4 kinase gene and related spliceosome factor genes in Trichophyton rubrum respond to nutrients and antifungals. J Med Microbiol. 68:591–599. 2019.PubMed/NCBI View Article : Google Scholar

22 

Cai W, Lu C, Li X, Zhang J, Zhan P, Xi L, Sun J and Yu X: Epidemiology of superficial fungal infections in Guangdong, Southern China: A retrospective study from 2004 to 2014. Mycopathologia. 181:387–395. 2018.PubMed/NCBI View Article : Google Scholar

23 

Havlickova B, Czaika VA and Friedrich M: Epidemiological trends in skin mycoses worldwide. Mycoses. 51 (Suppl 4):S2–S15. 2008.PubMed/NCBI View Article : Google Scholar

24 

Ginter-Hanselmayer G, Weger W, Ilkit M and Smolle J: Epidemiology of tinea capitis in Europe: Current state and changing patterns. Mycoses. 50 (Suppl 2):S6–S13. 2007.PubMed/NCBI View Article : Google Scholar

25 

Nasr A, Vyzantiadis TA, Patsatsi A, Louka A, Ioakimidou A, Zachrou E, Chavale A, Kalabalikis D, Malissiovas N and Sotiriadis D: Epidemiology of superficial mycoses in Northern Greece: A 4-year study. J Eur Acad Dermatol Venereol. 30:837–839. 2016.PubMed/NCBI View Article : Google Scholar

26 

Gawaz A and Weisel G: Mixed infections are a critical factor in the treatment of superficial mycoses. Mycoses. 61:731–735. 2018.PubMed/NCBI View Article : Google Scholar

27 

de Hoog S, Monod M, Dawson T, Boekhout T, Mayser P and Gräser Y: Skin fungi from colonization to infection. Microbiol Spectr Jul 5, 2017 (Epub ahead of print). doi: 0.1128/microbiolspec.FUNK-0049-2016.

28 

Bond R: Superficial veterinary mycoses. Clin Dermatol. 28:226–236. 2010.PubMed/NCBI View Article : Google Scholar

29 

Zhan P, Geng C, Li Z, Jin Y, Jiang Q, Tao L, Luo Y, Xiong Z, Wu S, Li D, et al: Evolution of tinea capitis in the Nanchang area, Southern China: A 50-year survey (1965-2014). Mycoses. 58:261–266. 2015.PubMed/NCBI View Article : Google Scholar

30 

Zhan P, Li D, Wang C, Sun J, Geng C, Xiong Z, Seyedmousavi S, Liu W and de Hoog GS: Epidemiological changes in tinea capitis over the sixty years of economic growth in China. Med Mycol. 53:691–698. 2015.PubMed/NCBI View Article : Google Scholar

31 

Chen M, Xu Y, Hong N, Yang Y, Lei W, Du L, Zhao J, Lei X, Xiong L, Cai L, et al: Epidemiology of fungal infections in China. Front Med. 12:58–75. 2018.PubMed/NCBI View Article : Google Scholar

32 

Tschachler E: The dermatologist and the HIV/AIDS pandemic. Clin Dermatol. 32:286–289. 2014.PubMed/NCBI View Article : Google Scholar

33 

Fay VDS, Rodrigues DMG, Gonçalves SMB, Gregianini TS and Bonamigo RR: Drug susceptibility in emerging fungal infections: Tests with fluconazole, itraconazole, and amphotericin B. An Bras Dermatol. 93:462–464. 2018.PubMed/NCBI View Article : Google Scholar

34 

Wypij M, Czarnecka J, Dahm H, Rai M and Golinska P: Silver nanoparticles from Pilimelia columellifera subsp. pallida SL19 strain demonstrated antifungal activity against fungi causing superficial mycoses. J Basic Microbiol. 57:793–800. 2017.PubMed/NCBI View Article : Google Scholar

35 

Durdu M, Güran M and Ilkit M: Epidemiological characteristics of Malassezia folliculitis and use of the May-Grünwald-Giemsa stain to diagnose the infection. Diagn Microbiol Infect Dis. 76:450–457. 2013.PubMed/NCBI View Article : Google Scholar

36 

Tsai YC, Wang JY, Wu YH and Wang YJ: Clinical differences in pediatric and adult Malassezia folliculitis: Retrospective analysis of 321 cases over 9 years. J Am Acad Dermatol. 81:278–280. 2019.PubMed/NCBI View Article : Google Scholar

37 

Harada K, Saito M, Sugita T and Tsuboi R: Malassezia species and their associated skin diseases. J Dermatol. 42:250–257. 2015.PubMed/NCBI View Article : Google Scholar

38 

Chakrabarti A, Bonifaz A, Gutierrez-Galhardo MC, Mochizuki T and Li S: Global epidemiology of sporotrichosis. Med Mycol. 53:3–14. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Ding C, Xu Y, Yu H, Zhang S and Yang C: Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10&nbsp;years. Exp Ther Med 20: 281, 2020.
APA
Wang, X., Ding, C., Xu, Y., Yu, H., Zhang, S., & Yang, C. (2020). Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10&nbsp;years. Experimental and Therapeutic Medicine, 20, 281. https://doi.org/10.3892/etm.2020.9411
MLA
Wang, X., Ding, C., Xu, Y., Yu, H., Zhang, S., Yang, C."Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10&nbsp;years". Experimental and Therapeutic Medicine 20.6 (2020): 281.
Chicago
Wang, X., Ding, C., Xu, Y., Yu, H., Zhang, S., Yang, C."Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10&nbsp;years". Experimental and Therapeutic Medicine 20, no. 6 (2020): 281. https://doi.org/10.3892/etm.2020.9411
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Ding C, Xu Y, Yu H, Zhang S and Yang C: Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10&nbsp;years. Exp Ther Med 20: 281, 2020.
APA
Wang, X., Ding, C., Xu, Y., Yu, H., Zhang, S., & Yang, C. (2020). Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10&nbsp;years. Experimental and Therapeutic Medicine, 20, 281. https://doi.org/10.3892/etm.2020.9411
MLA
Wang, X., Ding, C., Xu, Y., Yu, H., Zhang, S., Yang, C."Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10&nbsp;years". Experimental and Therapeutic Medicine 20.6 (2020): 281.
Chicago
Wang, X., Ding, C., Xu, Y., Yu, H., Zhang, S., Yang, C."Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10&nbsp;years". Experimental and Therapeutic Medicine 20, no. 6 (2020): 281. https://doi.org/10.3892/etm.2020.9411
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