Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes

  • Authors:
    • Yong Han
    • Min Chen
    • Hangzhou Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Children's Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 108
    |
    Published online on: November 27, 2020
       https://doi.org/10.3892/etm.2020.9540
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumor driver genes are genes where structural or sequence mutations confer a selective advantage for cancer cells. The individualized targeting of tumor driver genes has become a topic of interest for tumor treatment. The prognosis for medulloblastoma (MB), a common type of malignant intracranial tumor found in children, is poor. The tumor driver genes and the corresponding targeted drugs remain to be studied. The present study analyzed tumor driver genes from tumor tissue and peripheral blood from one patient with nodular desmoplastic MB with Sonic Hedgehog activation and screened targeted drugs for the tumor driver genes. Additionally, MB tissue was successfully implanted into the SCID mouse which were then used for subsequent drug screening. The present study explored novel treatments for MB from the perspective of tumor driver genes, and may provide new ideas for choosing individualized targeted therapies for patients with MB.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Kumar R, Liu AP and Northcott PA: Medulloblastoma genomics in the modern molecular era. Brain Pathol. 30:679–690. 2020.PubMed/NCBI View Article : Google Scholar

2 

Dhall G, O'Neil SH, Ji L, Haley K, Whitaker AM, Nelson MD, Gilles F, Gardner SL, Allen JC, Cornelius AS, et al: Excellent outcome of young children with nodular desmoplastic medulloblastoma treated on ‘Head Start’ III: A multi-institutional, prospective clinical trial. Neuro Oncol: Apr 18, 2020 (Epub ahead of print). doi: 10.1093/neuonc/noaa102.

3 

Batora NV, Sturm D, Jones DT, Kool M, Pfister SM and Northcott PA: Transitioning from genotypes to epigenotypes: Why the time has come for medulloblastoma epigenomics. Neuroscience. 264:171–185. 2014.PubMed/NCBI View Article : Google Scholar

4 

Ris MD, Packer R, Goldwein J, Jones-Wallace D and Boyett JM: Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: A Children's Cancer Group study. J Clin Oncol. 19:3470–3476. 2001.PubMed/NCBI View Article : Google Scholar

5 

Xu W, Janss A, Packer RJ, Phillips P, Goldwein J and Moshang T Jr: Endocrine outcome in children with medulloblastoma treated with 18 Gy of craniospinal radiation therapy. Neuro Oncol. 6:113–118. 2004.PubMed/NCBI View Article : Google Scholar

6 

Hoppe-Hirsch E, Renier D, Lellouch-Tubiana A, Sainte-Rose C, Pierre-Kahn A and Hirsch JF: Medulloblastoma in childhood: Progressive intellectual deterioration. Childs Nerv Syst. 6:60–65. 1990.PubMed/NCBI View Article : Google Scholar

7 

Chen P, Fan Y, Man TK, Hung YS, Lau CC and Wong ST: A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma. BMC Bioinformatics. 14 (Suppl 18)(S1)2013.PubMed/NCBI View Article : Google Scholar

8 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000.PubMed/NCBI View Article : Google Scholar

9 

Sanai N: Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma. World Neurosurg. 74:4–5. 2010.PubMed/NCBI View Article : Google Scholar

10 

Kool M, Koster J, Bunt J, Hasselt NE, Lakeman A, van Sluis P, Troost D, Meeteren NS, Caron HN, Cloos J, et al: Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One. 3(e3088)2008.PubMed/NCBI View Article : Google Scholar

11 

Yang J, Wang X, Kim M, Xie Y and Xiao G: Detection of candidate tumor driver genes using a fully integrated Bayesian approach. Stat Med. 33:1784–1800. 2014.PubMed/NCBI View Article : Google Scholar

12 

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr and Kinzler KW: Cancer genome landscapes. Science. 339:1546–1558. 2013.PubMed/NCBI View Article : Google Scholar

13 

Ohshima K, Hatakeyama K, Nagashima T, Watanabe Y, Kanto K, Doi Y, Ide T, Shimoda Y, Tanabe T, Ohnami S, et al: Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. Sci Rep. 7(641)2017.PubMed/NCBI View Article : Google Scholar

14 

Akavia UD, Litvin O, Kim J, Sanchez-Garcia F, Kotliar D, Causton HC, Pochanard P, Mozes E, Garraway LA and Pe'er D: An integrated approach to uncover drivers of cancer. Cell. 143:1005–1017. 2010.PubMed/NCBI View Article : Google Scholar

15 

Son EI, Kim IM, Kim DW, Yim MB, Kang YN, Lee SS, Kwon KY, Suh SI, Kwon TK, Lee JJ, et al: Immunohistochemical analysis for histopathological subtypes in pediatric medulloblastomas. Pathol Int. 53:67–73. 2003.PubMed/NCBI View Article : Google Scholar

16 

Aref D and Croul S: Medulloblastoma: Recurrence and metastasis. CNS Oncol. 2:377–385. 2013.PubMed/NCBI View Article : Google Scholar

17 

Kijima N and Kanemura Y: Molecular Classification of Medulloblastoma. Neurol Med Chir (Tokyo). 56:687–697. 2016.PubMed/NCBI View Article : Google Scholar

18 

Gottardo NG, Hansford JR, McGlade JP, Alvaro F, Ashley DM, Bailey S, Baker DL, Bourdeaut F, Cho YJ, Clay M, et al: Medulloblastoma Down Under 2013: A report from the third annual meeting of the International Medulloblastoma Working Group. Acta Neuropathol. 127:189–201. 2014.PubMed/NCBI View Article : Google Scholar

19 

Ferrucci V, de Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, et al: Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition. Brain. 141:1300–1319. 2018.PubMed/NCBI View Article : Google Scholar

20 

Wang J, Garancher A, Ramaswamy V and Wechsler-Reya RJ: Medulloblastoma: From molecular subgroups to molecular targeted therapies. Annu Rev Neurosci. 41:207–232. 2018.PubMed/NCBI View Article : Google Scholar

21 

Mackall CL: In search of targeted therapies for childhood cancer. Front Oncol. 1(18)2011.PubMed/NCBI View Article : Google Scholar

22 

Kumar V, Kumar V, McGuire T, Coulter DW, Sharp JG and Mahato RI: Challenges and recent advances in medulloblastoma therapy. Trends Pharmacol Sci. 38:1061–1084. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Han Y, Chen M and Wang H: Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes. Exp Ther Med 21: 108, 2021.
APA
Han, Y., Chen, M., & Wang, H. (2021). Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes. Experimental and Therapeutic Medicine, 21, 108. https://doi.org/10.3892/etm.2020.9540
MLA
Han, Y., Chen, M., Wang, H."Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes". Experimental and Therapeutic Medicine 21.2 (2021): 108.
Chicago
Han, Y., Chen, M., Wang, H."Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes". Experimental and Therapeutic Medicine 21, no. 2 (2021): 108. https://doi.org/10.3892/etm.2020.9540
Copy and paste a formatted citation
x
Spandidos Publications style
Han Y, Chen M and Wang H: Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes. Exp Ther Med 21: 108, 2021.
APA
Han, Y., Chen, M., & Wang, H. (2021). Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes. Experimental and Therapeutic Medicine, 21, 108. https://doi.org/10.3892/etm.2020.9540
MLA
Han, Y., Chen, M., Wang, H."Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes". Experimental and Therapeutic Medicine 21.2 (2021): 108.
Chicago
Han, Y., Chen, M., Wang, H."Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes". Experimental and Therapeutic Medicine 21, no. 2 (2021): 108. https://doi.org/10.3892/etm.2020.9540
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team