Open Access

Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes

  • Authors:
    • Yong Han
    • Min Chen
    • Hangzhou Wang
  • View Affiliations

  • Published online on: November 27, 2020     https://doi.org/10.3892/etm.2020.9540
  • Article Number: 108
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tumor driver genes are genes where structural or sequence mutations confer a selective advantage for cancer cells. The individualized targeting of tumor driver genes has become a topic of interest for tumor treatment. The prognosis for medulloblastoma (MB), a common type of malignant intracranial tumor found in children, is poor. The tumor driver genes and the corresponding targeted drugs remain to be studied. The present study analyzed tumor driver genes from tumor tissue and peripheral blood from one patient with nodular desmoplastic MB with Sonic Hedgehog activation and screened targeted drugs for the tumor driver genes. Additionally, MB tissue was successfully implanted into the SCID mouse which were then used for subsequent drug screening. The present study explored novel treatments for MB from the perspective of tumor driver genes, and may provide new ideas for choosing individualized targeted therapies for patients with MB.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Han Y, Chen M and Wang H: Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes. Exp Ther Med 21: 108, 2021
APA
Han, Y., Chen, M., & Wang, H. (2021). Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes. Experimental and Therapeutic Medicine, 21, 108. https://doi.org/10.3892/etm.2020.9540
MLA
Han, Y., Chen, M., Wang, H."Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes". Experimental and Therapeutic Medicine 21.2 (2021): 108.
Chicago
Han, Y., Chen, M., Wang, H."Production of a SCID mouse model of medulloblastoma to explore the therapeutic value of targeting tumor driver genes". Experimental and Therapeutic Medicine 21, no. 2 (2021): 108. https://doi.org/10.3892/etm.2020.9540