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Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway

  • Authors:
    • Yin-Hui Zhao
    • Cai-Fu Shen
    • Yan Kang
    • Ao Qi
    • Wen-Juan Xu
    • Wen-Hui Shi
    • Jiang-Wei Liu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of The Special Environmental Medicine of Xinjiang, General Hospital of Xinjiang Military Region of The PLA, Urumqi, Xinjiang 830000, P.R. China, Department of Imaging Medicine The 69240 Army Hospital of PLA, Urumqi, Xinjiang 830000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 126
    |
    Published online on: December 4, 2020
       https://doi.org/10.3892/etm.2020.9558
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Abstract

Heatstroke is a life‑threatening illness that is characterised by a core body temperature >40°C and central nervous system dysfunction. Acute kidney injury (AKI) is a common complication of heatstroke, and the mitochondrial apoptotic pathway has been demonstrated to be one of the leading causes of tissue damage and cell death in AKI. Curcumin is a phenol that is extracted from turmeric and demonstrates anti‑apoptotic properties. To test if curcumin can protect the kidney from injury caused by heat stress, the effect of curcumin administration on renal injury and apoptosis of renal tissue was examined in a rat model of dry‑heat environment. A total of 50 Sprague‑Dawley rats were randomly divided into five groups (n=10): Standard temperature control, dry‑heat control and curcumin treatment groups (50, 100 and 200 mg/kg groups). After exposure to a dry‑heat environment for 150 min, the rats were anesthetized and euthanized. Blood, urine and renal tissue were collected to quantify the expression of specific mitochondrial apoptosis‑related molecules. Curcumin pre‑treatment decreased blood urea nitrogen and serum creatinine, urinary kidney injury molecule‑1, and neutrophil gelatinase‑associated lipocalin levels compared with the dry‑heat control group. Curcumin was also revealed to downregulate c‑Jun N‑terminal kinases (JNK), cytochrome c, caspase‑3 and caspase‑9 expression upon treatment with 100 and 200 mg/kg curcumin, which may result in inhibition of the mitochondrial apoptotic pathway in renal cells. The current study revealed that Curcumin may to have potential for preventing heatstroke‑induced AKI.
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1 

Bouchama A and Knochel JP: Heat stroke. N Engl J Med. 346:1978–1988. 2002.PubMed/NCBI View Article : Google Scholar

2 

Al Mahri S and Bouchama A: Heatstroke. Handb Clin Neurol. 157:531–545. 2018.PubMed/NCBI View Article : Google Scholar

3 

Heled Y, Fleischmann C and Epstein Y: Cytokines and their role in hyperthermia and heatstroke. J Basic Clin Physiol Pharmacol. 24:85–96. 2013.PubMed/NCBI View Article : Google Scholar

4 

Bouchama A, Roberts G, Al Mohanna F, El-Sayed R, Lach B, Chollet-Martin S, Ollivier V, Al Baradei R, Loualich A, Nakeeb S, et al: Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke. J Appl Physiol (1985). 98:697–705. 2005.PubMed/NCBI View Article : Google Scholar

5 

Roberts GT, Ghebeh H, Chishti MA, Al-Mohanna F, El-Sayed R, Al-Mohanna F and Bouchama A: Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: A study in baboon model. Arterioscler Thromb Vasc Biol. 28:1130–1136. 2008.PubMed/NCBI View Article : Google Scholar

6 

Khogali M: Heat-related illnesses. Middle East J Anaesthesiol. 12:531–572. 1994.PubMed/NCBI

7 

Gong L, Zhang Q, Pan X, Chen S, Yang L, Liu B, Yang W, Yu L, Xiao ZX, Feng XH, et al: p53 protects cells from death at the heatstroke threshold temperature. Cell Rep. 29:3693–3707.e5. 2019.PubMed/NCBI View Article : Google Scholar

8 

Lim CL and Mackinnon LT: The roles of exercise-induced immune system disturbances in the pathology of heat stroke: The dual pathway model of heat stroke. Sports Med. 36:39–64. 2006.PubMed/NCBI View Article : Google Scholar

9 

Sakaguchi Y, Stephens CL, Makino M, Kaneko T, Strebel FR, Danhauser LL, Jenkins GN and Bull JM: Apoptosis in tumors and normal tissues induced by whole body hyperthermia in rats. Cancer Res. 55:5459–5464. 1995.PubMed/NCBI

10 

Unlu A, Nayir E, Dogukan Kalenderoglu M, Kirca O and Ozdogan M: Curcumin Turmeric) and cancer. J BUON. 21:1050–1060. 2016.PubMed/NCBI

11 

Anand P, Kunnumakkara AB, Newman RA and Aggarwal BB: Bioavailability of curcumin: Problems and promises. Mol Pharm. 4:807–818. 2007.PubMed/NCBI View Article : Google Scholar

12 

Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z and Sahebkar A: Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother. 85:102–112. 2017.PubMed/NCBI View Article : Google Scholar

13 

He L, Peng X, Zhu J, Liu G, Chen X, Tang C, Liu H, Liu F and Peng Y: Protective effects of curcumin on acute gentamicin-induced nephrotoxicity in rats. Can J Physiol Pharmacol. 93:275–282. 2015.PubMed/NCBI View Article : Google Scholar

14 

Abdel-Moneim AM, El-Toweissy MY, Ali AM, Awad Allah AA, Darwish HS and Sadek IS: Curcumin ameliorates lead (Pb(2+))-induced hemato-biochemical alterations and renal oxidative damage in a rat model. Biol Trace Elem Res. 168:206–220. 2015.PubMed/NCBI View Article : Google Scholar

15 

Hismiogullari AA, Hismiogullari SE, Karaca O, Sunay FB, Paksoy S, Can M, Kus I, Seyrek K and Yavuz O: The protective effect of curcumin administration on carbon tetrachloride (CCl4)-induced nephrotoxicity in rats. Pharmacol Rep. 67:410–416. 2015.PubMed/NCBI View Article : Google Scholar

16 

Jiang J, Liu J, Li J, Tao L, Wang Z, Yang L, Shi W and Ma N: Effect of curcumin on expressions of CD11b and CD19 in peripheral blood of heat stroke rats in a simulation dry-heat environment. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 31:221–224. 2019.PubMed/NCBI View Article : Google Scholar : (In Chinese).

17 

Cao W, Cao JJ, Liu JW, Li JJ, Shen CF, Song LY, Ma N, Shi WH and Xu Q: Effects of curcumin pretreatment on lung injury and HMGB-1 and ICAM-1 mRNA in heat stroke rats in desert dry heat environment. Prog Mod Biomed. 18:652–656. 2018.

18 

ou Zhou R, Liu JW, Zhang D and Zhang Q: Heatstroke model for desert dry-heat environment and observed organ damage. Am J Emerg Med. 32:573–579. 2014.PubMed/NCBI View Article : Google Scholar

19 

Zhu YH and Pei ZM: GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. Cell Mol Biol (Noisy-le-grand). 64:36–42. 2018.PubMed/NCBI

20 

Geng Y, Ma Q, Liu YN, Peng N, Yuan FF, Li XG, Li M, Wu YS, Li BL, Song WB, et al: Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis. J Hepatol. 63:622–633. 2015.PubMed/NCBI View Article : Google Scholar

21 

Ji J, Hong X, Su L and Liu Z: Proteomic identification of hippocalcin and its protective role in heatstroke-induced hypothalamic injury in mice. J Cell Physiol. 234:3775–3789. 2019.PubMed/NCBI View Article : Google Scholar

22 

Hsu YL, Yu HS, Lin HC, Wu KY, Yang RC and Kuo PL: Heat shock induces apoptosis through reactive oxygen species involving mitochondrial and death receptor pathways in corneal cells. Exp Eye Res. 93:405–412. 2011.PubMed/NCBI View Article : Google Scholar

23 

Milleron RS and Bratton SB: Heat shock induces apoptosis independently of any known initiator caspase-activating complex. J Biol Chem. 281:16991–17000. 2006.PubMed/NCBI View Article : Google Scholar

24 

North S and Hainaut P: P53 and cell cycle control: A finger in every pie. Pathol Biol (Paris). 48:255–270. 2000.PubMed/NCBI

25 

Ye F, Deng PY, Li D, Luo D, Li NS, Deng S, Deng HW and Li YJ: Involvement of endothelial cell-derived CGRP in heat stress-induced protection of endothelial function. Vasc Pharmacol. 46:238–246. 2007.PubMed/NCBI View Article : Google Scholar

26 

Kerr JF, Wyllie AH and Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:239–257. 1972.PubMed/NCBI View Article : Google Scholar

27 

Jeong SY and Seol DW: The role of mitochondria in apoptosis. BMB Rep. 41:11–22. 2008.PubMed/NCBI View Article : Google Scholar

28 

Santra S, Kaittanis C and Perez JM: Cytochrome C encapsulating theranostic nanoparticles: A novel bifunctional system for targeted delivery of therapeutic membrane-impermeable proteins to tumors and imaging of cancer therapy. Mol Pharm. 7:1209–1222. 2010.PubMed/NCBI View Article : Google Scholar

29 

Yamada Y and Harashima H: Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Adv Drug Deliv Rev. 60:1439–1462. 2008.PubMed/NCBI View Article : Google Scholar

30 

Wang Y, Xia C, Lun Z, Lv Y, Chen W and Li T: Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells. Oncol Rep. 39:61–70. 2018.PubMed/NCBI View Article : Google Scholar

31 

Chen YJ, Liu WH, Kao PH, Wang JJ and Chang LS: Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells. Toxicon. 55:1306–1316. 2010.PubMed/NCBI View Article : Google Scholar

32 

Deng YT, Huang HC and Lin JK: Rotenone induces apoptosis in MCF07 human breast cancer cell-mediated ROS through JNK and p38 signaling. Mol Carcinog. 49:141–151. 2010.PubMed/NCBI View Article : Google Scholar

33 

Kang YH and Lee SJ: The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. J Cell Physiol. 217:23–33. 2008.PubMed/NCBI View Article : Google Scholar

34 

Su JC, Lin KL, Chien CM, Lu CM, Chen YL, Chang LS and Lin SR: Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sci. 85:505–516. 2009.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Shen C, Kang Y, Qi A, Xu W, Shi W and Liu J: Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway. Exp Ther Med 21: 126, 2021.
APA
Zhao, Y., Shen, C., Kang, Y., Qi, A., Xu, W., Shi, W., & Liu, J. (2021). Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway. Experimental and Therapeutic Medicine, 21, 126. https://doi.org/10.3892/etm.2020.9558
MLA
Zhao, Y., Shen, C., Kang, Y., Qi, A., Xu, W., Shi, W., Liu, J."Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway". Experimental and Therapeutic Medicine 21.2 (2021): 126.
Chicago
Zhao, Y., Shen, C., Kang, Y., Qi, A., Xu, W., Shi, W., Liu, J."Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway". Experimental and Therapeutic Medicine 21, no. 2 (2021): 126. https://doi.org/10.3892/etm.2020.9558
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Shen C, Kang Y, Qi A, Xu W, Shi W and Liu J: Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway. Exp Ther Med 21: 126, 2021.
APA
Zhao, Y., Shen, C., Kang, Y., Qi, A., Xu, W., Shi, W., & Liu, J. (2021). Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway. Experimental and Therapeutic Medicine, 21, 126. https://doi.org/10.3892/etm.2020.9558
MLA
Zhao, Y., Shen, C., Kang, Y., Qi, A., Xu, W., Shi, W., Liu, J."Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway". Experimental and Therapeutic Medicine 21.2 (2021): 126.
Chicago
Zhao, Y., Shen, C., Kang, Y., Qi, A., Xu, W., Shi, W., Liu, J."Curcumin prevents renal cell apoptosis in acute kidney injury in a rat model of dry‑heat environment heatstroke via inhibition of the mitochondrial apoptotic pathway". Experimental and Therapeutic Medicine 21, no. 2 (2021): 126. https://doi.org/10.3892/etm.2020.9558
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