Open Access

Confronting the threat of SARS‑CoV‑2: Realities, challenges and therapeutic strategies (Review)

  • Authors:
    • Ruixue Wang
    • Xiaoshan Luo
    • Fang Liu
    • Shuhong Luo
  • View Affiliations

  • Published online on: December 17, 2020     https://doi.org/10.3892/etm.2020.9587
  • Article Number: 155
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The novel coronavirus (SARS‑CoV‑2) appeared in2019 in Wuhan, China, and rapidly developed into a global pandemic. The disease has affected not only health care systems and economies worldwide but has also changed the lifestyles and habits of the majority of the world's population. Among the potential targets for SARS‑CoV‑2 therapy, the viral spike glycoprotein has been studied most intensely, due to its key role in mediating viral entry into target cells and inducing a protective antibody response in infected individuals. In the present manuscript the molecular mechanisms that are responsible for SARS‑CoV‑2 infection are described and a progress report on the status of SARS‑CoV‑2 research is provided. A brief review of the clinical symptoms of the condition and current diagnostic methods and treatment plans for SARS‑CoV‑2 are also presented and the progress of preclinical research into medical intervention against SARS‑CoV‑2 infection are discussed.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang R, Luo X, Liu F and Luo S: Confronting the threat of SARS‑CoV‑2: Realities, challenges and therapeutic strategies (Review). Exp Ther Med 21: 155, 2021
APA
Wang, R., Luo, X., Liu, F., & Luo, S. (2021). Confronting the threat of SARS‑CoV‑2: Realities, challenges and therapeutic strategies (Review). Experimental and Therapeutic Medicine, 21, 155. https://doi.org/10.3892/etm.2020.9587
MLA
Wang, R., Luo, X., Liu, F., Luo, S."Confronting the threat of SARS‑CoV‑2: Realities, challenges and therapeutic strategies (Review)". Experimental and Therapeutic Medicine 21.2 (2021): 155.
Chicago
Wang, R., Luo, X., Liu, F., Luo, S."Confronting the threat of SARS‑CoV‑2: Realities, challenges and therapeutic strategies (Review)". Experimental and Therapeutic Medicine 21, no. 2 (2021): 155. https://doi.org/10.3892/etm.2020.9587