Open Access

Clinical significance of serum transforming growth factor‑β1 and procollagen type I N‑propeptide in post‑tuberculosis tracheobronchial stenosis

  • Authors:
    • Yongchang Wu
    • Yishi Li
    • Yang Bai
    • Jinyue Jiang
    • Xiaohui Wang
    • Yi Chen
    • Xin Wang
    • Guichuan Huang
    • Yiling Gan
    • You Li
    • Shuliang Guo
  • View Affiliations

  • Published online on: March 29, 2021     https://doi.org/10.3892/etm.2021.10002
  • Article Number: 570
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑invasive strategies for monitoring post‑­tuberculosis (TB) tracheobronchial stenosis (PTTS) are clinically important but currently lacking. Transforming growth factor‑β1 (TGF‑β1) and procollagen type I N‑propeptide (PINP) have been identified as markers of fibrosis. The present study aimed to investigate the clinical significance of serum TGF‑β1 and PINP in PTTS. Serum samples were collected from 119 patients with tracheobronchial TB after the condition was treated for at least 6 months (59 patients with airway stenosis and 60 patients with no stenosis). Serum TGF‑β1 and PINP levels were measured using ELISA and compared between the groups. Relationships between serum TGF‑β1 and PINP levels and clinical characteristics, interventional bronchoscopy and outcomes of airway stenosis were analysed. The correlation between TGF‑β1 and PINP, and their diagnostic efficacy for airway stenosis were also analysed. The TGF‑β1 and PINP levels in the airway stenosis group were higher than those in the non‑stenosis group. Furthermore, airway stenosis with atelectasis or mucus plugging was associated with higher TGF‑β1 levels, and airway stenosis with atelectasis, mucus plugging, right main bronchus stenosis or severe airway tracheal stenosis was associated with higher PINP levels. In addition, TGF‑β1 and PINP levels increased after interventional bronchoscopy therapy and airway stenosis with recurrent stenosis was associated with higher baseline levels of both markers. Finally, TGF‑β1 levels were positively correlated with PINP levels in patients with airway stenosis. The area under the receiver operating characteristic curve of TGF‑β1 and PINP for distinguishing airway stenosis from non‑stenosis cases was 0.824 (95% CI: 0.748‑0.900) and 0.863 (95% CI: 0.796‑0.930), respectively. Therefore, TGF‑β1 and PINP are potential biomarkers that may be useful for diagnosing and monitoring PTTS.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wu Y, Li Y, Bai Y, Jiang J, Wang X, Chen Y, Wang X, Huang G, Gan Y, Li Y, Li Y, et al: Clinical significance of serum transforming growth factor‑β1 and procollagen type I N‑propeptide in post‑tuberculosis tracheobronchial stenosis. Exp Ther Med 21: 570, 2021
APA
Wu, Y., Li, Y., Bai, Y., Jiang, J., Wang, X., Chen, Y. ... Guo, S. (2021). Clinical significance of serum transforming growth factor‑β1 and procollagen type I N‑propeptide in post‑tuberculosis tracheobronchial stenosis. Experimental and Therapeutic Medicine, 21, 570. https://doi.org/10.3892/etm.2021.10002
MLA
Wu, Y., Li, Y., Bai, Y., Jiang, J., Wang, X., Chen, Y., Wang, X., Huang, G., Gan, Y., Li, Y., Guo, S."Clinical significance of serum transforming growth factor‑β1 and procollagen type I N‑propeptide in post‑tuberculosis tracheobronchial stenosis". Experimental and Therapeutic Medicine 21.6 (2021): 570.
Chicago
Wu, Y., Li, Y., Bai, Y., Jiang, J., Wang, X., Chen, Y., Wang, X., Huang, G., Gan, Y., Li, Y., Guo, S."Clinical significance of serum transforming growth factor‑β1 and procollagen type I N‑propeptide in post‑tuberculosis tracheobronchial stenosis". Experimental and Therapeutic Medicine 21, no. 6 (2021): 570. https://doi.org/10.3892/etm.2021.10002