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The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma

  • Authors:
    • Shu Luo
    • Xing Jiang
    • Gang Yin
    • Yajun Liu
    • Zhou Liu
    • Linglian Meng
    • Jian Wu
    • Haoxin Wu
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Nursing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Science and Technology, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China, Department of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, Central Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 573
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    Published online on: March 31, 2021
       https://doi.org/10.3892/etm.2021.10005
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Abstract

Plantamajoside (PMS), a major component of Plantago asiatica L, has several pharmacological properties, including anti‑proliferative, anti‑inflammatory and anti‑tumor effects. However, the effects of PMS on hepatocellular carcinoma (HCC) have yet to be determined. The aim of the present study was to investigate the effects of PMS on HCC and elucidate the underlying mechanism. All assays were conducted using 5 groups, namely control, sorafenib, and PMS 100, 50, and 25 µg/ml groups. Cell proliferation was determined by the MTT assay. Cell migration was evaluated with the wound healing and Transwell assays, respectively. Cell apoptosis and cell cycle distribution were evaluated via flow cytometry. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis and western blotting were used to further investigate the mechanism of action of PMS. Sorafenib and PMS both significantly attenuated the proliferation and migration of HCC cells, and markedly promoted cell apoptosis. PMS induced cell cycle arrest in the G0/G1 phase. The efficacy of PMS increased in a dose‑dependent manner. Further study evaluated the expression of peroxisome proliferator‑activated receptor (PPARγ), nuclear factor (NF)‑κB and cyclooxygenase (Cox‑2) using RT‑qPCR analysis and western blotting. The results demonstrated that PMS promoted the expression of PPARγ and suppressed the expression of NF‑κB and Cox‑2. In conclusion, PMS was shown to affect cell proliferation, migration, apoptosis and cell cycle distribution. Furthermore, PMS promoted the expression of PPARγ and inhibited the expression of NF‑κB and Cox‑2, which may be the mechanism underlying its biological effects. Based on the results of the present study, PMS appears to be a promising agent for HCC therapy.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015.PubMed/NCBI View Article : Google Scholar

2 

Jiang BG, Wang N, Huang J, Yang Y, Sun LL, Pan ZY and Zhou WP: Tumor SOCS3 methylation status predicts the treatment response to TACE and prognosis in HCC patients. Oncotarget. 8:28621–28627. 2017.PubMed/NCBI View Article : Google Scholar

3 

Guo XL, Li D, Hu F, Song JR, Zhang SS, Deng WJ, Sun K, Zhao QD, Xie XQ, Song YJ, et al: Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett. 320:171–179. 2012.PubMed/NCBI View Article : Google Scholar

4 

Tontonoz P and Spiegelman BM: Fat and beyond: The diverse biology of PPARgamma. Ann Rev Biochemistry. 77:289–312. 2008.PubMed/NCBI View Article : Google Scholar

5 

Heudobler D, Rechenmacher M, Lüke F, Vogelhuber M, Pukrop T, Herr W, Ghibelli L, Gerner C and Reichle A: Peroxisome proliferator-activated receptors (PPAR)γ agonists as master modulators of tumor tissue. Int J Mol Sci. 19(3540)2018.PubMed/NCBI View Article : Google Scholar

6 

Shen B, Chu ES, Zhao G, Man K, Wu CW, Cheng JT, Li G, Nie Y, Lo CM, Teoh N, et al: PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice. Br J Cancer. 106:1486–1494. 2012.PubMed/NCBI View Article : Google Scholar

7 

Yu J, Shen B, Chu ES, Teoh N, Cheung KF, Wu CW, Wang S, Lam CN, Feng H, Zhao J, et al: Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro. Hepatology. 51:2008–2019. 2010.PubMed/NCBI View Article : Google Scholar

8 

Nojima H, Kuboki S, Shinoda K, Shimizu H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K, Takayashiki T and Miyazaki M: Activation of peroxisome proliferator-activated receptor-gamma inhibits tumor growth by negatively regulating nuclear factor-κB activation in patients with hepatocellular carcinoma. J Hepatobiliary Pancreat Sci. 23:574–584. 2016.PubMed/NCBI View Article : Google Scholar

9 

Zhang N, Chu ES, Zhang J, Li X, Liang Q, Chen J, Chen M, Teoh N, Farrell G, Sung JJ and Yu J: Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-kappaB signaling pathway. Oncotarget. 5:8330–8340. 2014.PubMed/NCBI View Article : Google Scholar

10 

Kern MA, Schoneweiss MM, Sahi D, Bahlo M, Haugg AM, Kasper HU, Dienes HP, Käferstein H, Breuhahn K and Schirmacher P: Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice. Carcinogenesis. 25:1193–1199. 2004.PubMed/NCBI View Article : Google Scholar

11 

Tsatsanis C, Androulidaki A, Venihaki M and Margioris AN: Signalling networks regulating cyclooxygenase-2. Int J Biochem Cell Biol. 38:1654–1661. 2006.PubMed/NCBI View Article : Google Scholar

12 

Wu H, Zhao G, Jiang K, Chen X, Zhu Z, Qiu C, Li C and Deng G: Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation. Int Immunopharmacol. 35:315–322. 2016.PubMed/NCBI View Article : Google Scholar

13 

Pei S, Yang X, Wang H, Zhang H, Zhou B, Zhang D and Lin D: Plantamajoside, a potential anti-tumor herbal medicine inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of matrix metalloproteinase-9 and -2. BMC Cancer. 15(965)2015.PubMed/NCBI View Article : Google Scholar

14 

Li X, Chen D, Li M, Gao X, Shi G and Zhao H: Plantamajoside inhibits lipopolysaccharide-induced epithelial-mesenchymal transition through suppressing the NF-κB/IL-6 signaling in esophageal squamous cell carcinoma cells. Biomed Pharmacother. 102:1045–1051. 2018.PubMed/NCBI View Article : Google Scholar

15 

Han AR, Nam MH and Lee KW: Plantamajoside inhibits UVB and advanced glycation end products-induced MMP-1 expression by suppressing the MAPK and NF-κB pathways in HaCaT cells. Photochem Photobiol. 92:708–719. 2016.PubMed/NCBI View Article : Google Scholar

16 

Ma C and Ma W: Plantamajoside inhibits lipopolysaccharide-induced MUC5AC expression and inflammation through suppressing the PI3K/Akt and NF-κB signaling pathways in human airway epithelial cells. Inflammation. 41:795–802. 2018.PubMed/NCBI View Article : Google Scholar

17 

Son WR, Nam MH, Hong CO, Kim Y and Lee KW: Plantamajoside from Plantago asiatica modulates human umbilical vein endothelial cell dysfunction by glyceraldehyde-induced AGEs via MAPK/NF-κB. BMC Complement Altern Med. 17(66)2017.PubMed/NCBI View Article : Google Scholar

18 

Lee G, Elwood F, McNally J, Weiszmann J, Lindstrom M, Amaral K, Nakamura M, Miao S, Cao P, Learned RM, et al: T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 277:19649–19657. 2002.PubMed/NCBI View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

20 

Yao P, Li Y, Shen W, Xu X, Zhu W, Yang X, Cao J and Xing C: ANKHD1 silencing suppresses the proliferation, migration and invasion of CRC cells by inhibiting YAP1-induced activation of EMT. Am J Cancer Res. 8:2311–2324. 2018.PubMed/NCBI

21 

Tchakarska G and Sola B: The double dealing of cyclin D1. Cell Cycle. 19:163–178. 2020.PubMed/NCBI View Article : Google Scholar

22 

Kalpage HA, Bazylianska V, Recanati MA, Fite A, Liu J, Wan J, Mantena N, Malek MH, Podgorski I, Heath EI, et al: Tissue-specific regulation of cytochrome c by post-translational modifications: Respiration, the mitochondrial membrane potential, ROS, and apoptosis. FASEB J. 33:1540–1553. 2019.PubMed/NCBI View Article : Google Scholar

23 

Sarris J, Panossian A, Schweitzer I, Stough C and Scholey A: Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 21:841–860. 2011.PubMed/NCBI View Article : Google Scholar

24 

Feng YX, Wang T, Deng YZ, Yang P, Li JJ, Guan DX, Yao F, Zhu YQ, Qin Y, Wang H, et al: Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology. 53:483–492. 2011.PubMed/NCBI View Article : Google Scholar

25 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008.PubMed/NCBI View Article : Google Scholar

26 

Han M, Gao H, Ju P, Gao MQ, Yuan YP, Chen XH, Liu KL, Han YT and Han ZW: Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARγ. Biomed Pharmacother. 103:272–283. 2018.PubMed/NCBI View Article : Google Scholar

27 

Liu YI, Liu Z, Chen Y, Xu K and Dong J: PPARγ activation reduces ischemia/reperfusion-induced metastasis in a murine model of hepatocellular carcinoma. Exp Ther Med. 11:387–396. 2016.PubMed/NCBI View Article : Google Scholar

28 

Takahashi N, Okumura T, Motomura W, Fujimoto Y, Kawabata I and Kohgo Y: Activation of PPARγ inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett. 455:135–139. 1999.PubMed/NCBI View Article : Google Scholar

29 

Bock FJ and Tait SWG: Mitochondria as multifaceted regulators of cell death. Nature reviews. Mol Cell Biol. 21:85–100. 2020.PubMed/NCBI View Article : Google Scholar

30 

Bendris N, Lemmers B and Blanchard JM: Cell cycle, cytoskeleton dynamics and beyond: The many functions of cyclins and CDK inhibitors. Cell Cycle. 14:1786–1798. 2015.PubMed/NCBI View Article : Google Scholar

31 

Niu Z, Shi Q, Zhang W, Shu Y, Yang N, Chen B, Wang Q, Zhao X, Chen J, Cheng N, et al: Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs. Nat Commun. 8(766)2017.PubMed/NCBI View Article : Google Scholar

32 

Zhao T, Du H, Blum JS and Yan C: Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis. Oncotarget. 7:1529–1543. 2016.PubMed/NCBI View Article : Google Scholar

33 

Cheng J, Miao B, Hu KQ, Fu X and Wang XD: Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ. J Nutr Biochem. 56:26–34. 2018.PubMed/NCBI View Article : Google Scholar

34 

Ikawa H, Kameda H, Kamitani H, Baek SJ, Nixon JB, Hsi LC and Eling TE: Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. Exp Cell Res. 267:73–80. 2001.PubMed/NCBI View Article : Google Scholar

35 

Han S, Inoue H, Flowers LC and Sidell N: Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells. Clin Cancer Res. 9:4627–4635. 2003.PubMed/NCBI

36 

Cildir G, Low KC and Tergaonkar V: Noncanonical NF-κB signaling in health and disease. Trends Mol Med. 22:414–429. 2016.PubMed/NCBI View Article : Google Scholar

37 

Xiong S, Wang Y, Li H and Zhang X: Low dose of bisphenol a activates NF-κB/IL-6 signals to increase malignancy of neuroblastoma cells. Cell Mol Neurobiol. 37:1095–1103. 2017.PubMed/NCBI View Article : Google Scholar

38 

Bren-Mattison Y, Meyer AM, Van Putten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE and Nemenoff RA: Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. Mol Pharmacol. 73:709–717. 2008.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Luo S, Jiang X, Yin G, Liu Y, Liu Z, Meng L, Wu J and Wu H: The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma. Exp Ther Med 21: 573, 2021.
APA
Luo, S., Jiang, X., Yin, G., Liu, Y., Liu, Z., Meng, L. ... Wu, H. (2021). The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma. Experimental and Therapeutic Medicine, 21, 573. https://doi.org/10.3892/etm.2021.10005
MLA
Luo, S., Jiang, X., Yin, G., Liu, Y., Liu, Z., Meng, L., Wu, J., Wu, H."The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma". Experimental and Therapeutic Medicine 21.6 (2021): 573.
Chicago
Luo, S., Jiang, X., Yin, G., Liu, Y., Liu, Z., Meng, L., Wu, J., Wu, H."The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma". Experimental and Therapeutic Medicine 21, no. 6 (2021): 573. https://doi.org/10.3892/etm.2021.10005
Copy and paste a formatted citation
x
Spandidos Publications style
Luo S, Jiang X, Yin G, Liu Y, Liu Z, Meng L, Wu J and Wu H: The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma. Exp Ther Med 21: 573, 2021.
APA
Luo, S., Jiang, X., Yin, G., Liu, Y., Liu, Z., Meng, L. ... Wu, H. (2021). The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma. Experimental and Therapeutic Medicine, 21, 573. https://doi.org/10.3892/etm.2021.10005
MLA
Luo, S., Jiang, X., Yin, G., Liu, Y., Liu, Z., Meng, L., Wu, J., Wu, H."The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma". Experimental and Therapeutic Medicine 21.6 (2021): 573.
Chicago
Luo, S., Jiang, X., Yin, G., Liu, Y., Liu, Z., Meng, L., Wu, J., Wu, H."The herbal agent plantamajoside, exerts a potential inhibitory effect on the development of hepatocellular carcinoma". Experimental and Therapeutic Medicine 21, no. 6 (2021): 573. https://doi.org/10.3892/etm.2021.10005
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