Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma

  • Authors:
    • Tao Yu
    • Shuang Liang
    • Tianhong Ma
    • Weidong Song
  • View Affiliations

  • Published online on: April 8, 2021     https://doi.org/10.3892/etm.2021.10024
  • Article Number: 592
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Abstract

Osteosarcoma (OS) is a primary malignant tumor characterized by a high metastatic potential and poor prognosis. The dysregulation of miR‑588 has been demonstrated to serve crucial roles in the progression of numerous types of cancer. The present study aimed to investigate the expression and function of miR‑588 in the development of OS. To do so, clinical samples were collected and analyzed, and in vitro experiments were conducted. A total of 104 patients with OS were recruited between 2012 and 2014. The expression of miR‑588 was analyzed by reverse transcription quantitative PCR. The association between miR‑588 expression and the clinicopathological characteristics and survival rate of patients with OS was evaluated. Furthermore, Cell Counting Kit‑8 and Transwell assays were used to evaluate the effect of miR‑588 on the proliferation and the migratory and invasive abilities of various OS cell lines. The results demonstrated that miR‑588 expression in OS tissues and cells was significantly lower compared with normal tissues and cells. In addition, miR‑588 expression was closely associated with the Musculoskeletal Tumor Society (MSTS) staging of patients with OS. miR‑588 expression and MSTS staging were therefore considered as independent indicators for the prognosis of patients with OS. In addition, miR‑588 downregulation significantly stimulated the proliferation and migratory and invasive abilities of OS cells. Taken together, these findings indicated that miR‑588 may serve as an independent prognostic factor and tumor suppressor in OS.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yu T, Liang S, Ma T and Song W: Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma. Exp Ther Med 21: 592, 2021
APA
Yu, T., Liang, S., Ma, T., & Song, W. (2021). Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma. Experimental and Therapeutic Medicine, 21, 592. https://doi.org/10.3892/etm.2021.10024
MLA
Yu, T., Liang, S., Ma, T., Song, W."Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma". Experimental and Therapeutic Medicine 21.6 (2021): 592.
Chicago
Yu, T., Liang, S., Ma, T., Song, W."Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma". Experimental and Therapeutic Medicine 21, no. 6 (2021): 592. https://doi.org/10.3892/etm.2021.10024