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Article

Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma

  • Authors:
    • Tao Yu
    • Shuang Liang
    • Tianhong Ma
    • Weidong Song
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Second Affiliated Hospital of Mudanjiang University, Mudanjiang, Heilongjiang 157009, P.R China, Department of Radiology, Hongqi Hospital Affiliated to Mudanjiang Medical College, Mudanjiang, Heilongjiang 157009, P.R China
  • Article Number: 592
    |
    Published online on: April 8, 2021
       https://doi.org/10.3892/etm.2021.10024
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Abstract

Osteosarcoma (OS) is a primary malignant tumor characterized by a high metastatic potential and poor prognosis. The dysregulation of miR‑588 has been demonstrated to serve crucial roles in the progression of numerous types of cancer. The present study aimed to investigate the expression and function of miR‑588 in the development of OS. To do so, clinical samples were collected and analyzed, and in vitro experiments were conducted. A total of 104 patients with OS were recruited between 2012 and 2014. The expression of miR‑588 was analyzed by reverse transcription quantitative PCR. The association between miR‑588 expression and the clinicopathological characteristics and survival rate of patients with OS was evaluated. Furthermore, Cell Counting Kit‑8 and Transwell assays were used to evaluate the effect of miR‑588 on the proliferation and the migratory and invasive abilities of various OS cell lines. The results demonstrated that miR‑588 expression in OS tissues and cells was significantly lower compared with normal tissues and cells. In addition, miR‑588 expression was closely associated with the Musculoskeletal Tumor Society (MSTS) staging of patients with OS. miR‑588 expression and MSTS staging were therefore considered as independent indicators for the prognosis of patients with OS. In addition, miR‑588 downregulation significantly stimulated the proliferation and migratory and invasive abilities of OS cells. Taken together, these findings indicated that miR‑588 may serve as an independent prognostic factor and tumor suppressor in OS.
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1 

Picci P: Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis. 2(6)2007.PubMed/NCBI View Article : Google Scholar

2 

Ottaviani G and Jaffe N: The epidemiology of osteosarcoma. Cancer Treat Res. 152:3–13. 2009.PubMed/NCBI View Article : Google Scholar

3 

Liu W, Zhang X, Liu P, Shen X, Lan T, Li W, Jiang Q, Xie X and Huang H: Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury. Eur J Pharmacol. 638:150–155. 2010.PubMed/NCBI View Article : Google Scholar

4 

Yoshida K, Okamoto M, Aoki K, Takahashi J and Saito N: A Review of T-Cell Related Therapy for Osteosarcoma. Int J Mol Sci. 21(4877)2020.PubMed/NCBI View Article : Google Scholar

5 

Punzalan M and Hyden G: The role of physical therapy and occupational therapy in the rehabilitation of pediatric and adolescent patients with osteosarcoma. Cancer Treat Res. 152:367–384. 2009.PubMed/NCBI View Article : Google Scholar

6 

Daw NC, Chou AJ, Jaffe N, Rao BN, Billups CA, Rodriguez-Galindo C, Meyers PA and Huh WW: Recurrent osteosarcoma with a single pulmonary metastasis: A multi-institutional review. Br J Cancer. 112:278–282. 2015.PubMed/NCBI View Article : Google Scholar

7 

Meazza C and Scanagatta P: Metastatic osteosarcoma: A challenging multidisciplinary treatment. Expert Rev Anticancer Ther. 16:543–556. 2016.PubMed/NCBI View Article : Google Scholar

8 

Sun HH, Chen XY, Cui JQ, Zhou ZM and Guo KJ: Prognostic factors to survival of patients with chondroblastic osteosarcoma. Medicine (Baltimore). 97(e12636)2018.PubMed/NCBI View Article : Google Scholar

9 

Imura Y, Takenaka S, Kakunaga S, Nakai T, Wakamatsu T, Outani H, Tanaka T, Tamiya H, Oshima K, Hamada K, et al: Survival analysis of elderly patients with osteosarcoma. Int Orthop. 43:1741–1747. 2019.PubMed/NCBI View Article : Google Scholar

10 

Liao YX, Yu HY, Lv JY, Cai YR, Liu F, He ZM and He SS: Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma. Int J Oncol. 55:1213–1222. 2019.PubMed/NCBI View Article : Google Scholar

11 

Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science. 294:853–858. 2001.PubMed/NCBI View Article : Google Scholar

12 

Qiao W, Cao N and Yang L: MicroRNA-154 inhibits the growth and metastasis of gastric cancer cells by directly targeting MTDH. Oncol Lett. 14:3268–3274. 2017.PubMed/NCBI View Article : Google Scholar

13 

Yang ZQ, Wu CA and Cheng YX: Prognostic value of microRNA-133a expression and its clinicopathologic significance in non-small cell lung cancer: a comprehensive study based on meta-analysis and the TCGA database. Oncol Res Treat. 41:762–768. 2018.PubMed/NCBI View Article : Google Scholar

14 

Li C, Zhang J, Ma Z, Zhang F and Yu W: miR-19b serves as a prognostic biomarker of breast cancer and promotes tumor progression through PI3K/AKT signaling pathway. OncoTargets Ther. 11:4087–4095. 2018.PubMed/NCBI View Article : Google Scholar

15 

Wang L, Xu M, Lu P and Zhou F: microRNA-769 is downregulated in colorectal cancer and inhibits cancer progression by directly targeting cyclin-dependent kinase 1. OncoTargets Ther. 11:9013–9025. 2018.PubMed/NCBI View Article : Google Scholar

16 

Ji Q, Xu X, Song Q, Xu Y, Tai Y, Goodman SB, Bi W, Xu M, Jiao S, Maloney WJ, et al: miR-223-3p inhibits human osteosarcoma metastasis and progression by directly targeting CDH6. Mol Ther. 26:1299–1312. 2018.PubMed/NCBI View Article : Google Scholar

17 

Cai W, Xu Y, Yin J, Zuo W and Su Z: miR-552-5p facilitates osteosarcoma cell proliferation and metastasis by targeting WIF1. Exp Ther Med. 17:3781–3788. 2019.PubMed/NCBI View Article : Google Scholar

18 

Yu M, Zhang X, Li H, Zhang P and Dong W: MicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer. Med Sci Monit. 23:5690–5696. 2017.PubMed/NCBI View Article : Google Scholar

19 

Zhao N, Lin T, Zhao C, Zhao S, Zhou S and Li Y: MicroRNA-588 is upregulated in human prostate cancer with prognostic and functional implications. J Cell Biochem: Oct 5, 2017 (Epub ahead of print).

20 

Zhou X and Xu M, Guo Y, Ye L, Long L, Wang H, Tan P and Xu M: MicroRNA-588 regulates invasion, migration and epithelial-mesenchymal transition via targeting EIF5A2 pathway in gastric cancer. Cancer Manag Res. 10:5187–5197. 2018.PubMed/NCBI View Article : Google Scholar

21 

Qian L, Lin L, Du Y, Hao X, Zhao Y and Liu X: MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma. Mol Med Rep. 14:3021–3028. 2016.PubMed/NCBI View Article : Google Scholar

22 

Chen G, Yu W, Li Z, Wang Q, Yang Q, Du Z, Zhang G and Song Y: Potential regulatory effects of miR-182-3p in osteosarcoma via targeting EBF2. BioMed Res Int. 2019(4897905)2019.PubMed/NCBI View Article : Google Scholar

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

24 

Wang SY, Hu HZ, Qing XC, Zhang ZC and Shao ZW: Recent advances of drug delivery nanocarriers in osteosarcoma treatment. J Cancer. 11:69–82. 2020.PubMed/NCBI View Article : Google Scholar

25 

Qiu S, Tao L and Zhu Y: Marital Status and Survival in Osteosarcoma Patients: An Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database. Med Sci Monit. 25:8190–8203. 2019.PubMed/NCBI View Article : Google Scholar

26 

Bushati N and Cohen SM: microRNA functions. Annu Rev Cell Dev Biol. 23:175–205. 2007.PubMed/NCBI View Article : Google Scholar

27 

Mohr AM and Mott JL: Overview of microRNA biology. Semin Liver Dis. 35:3–11. 2015.PubMed/NCBI View Article : Google Scholar

28 

Wang J, Liu S, Shi J, Li J, Wang S, Liu H, Zhao S, Duan K, Pan X and Yi Z: The Role of miRNA in the Diagnosis, Prognosis, and Treatment of Osteosarcoma. Cancer Biother Radiopharm. 34:605–613. 2019.PubMed/NCBI View Article : Google Scholar

29 

Shi YK and Guo YH: MiR-139-5p suppresses osteosarcoma cell growth and invasion through regulating DNMT1. Biochem Biophys Res Commun. 503:459–466. 2018.PubMed/NCBI View Article : Google Scholar

30 

Iorio MV and Croce CM: MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med. 4:143–159. 2012.PubMed/NCBI View Article : Google Scholar

31 

Shi YX, Ye BL, Hu BR and Ruan XJ: Expression of miR-1294 is downregulated and predicts a poor prognosis in gastric cancer. Eur Rev Med Pharmacol Sci. 22:5525–5530. 2018.PubMed/NCBI View Article : Google Scholar

32 

Chen Y, Gao DY and Huang L: In vivo delivery of miRNAs for cancer therapy: Challenges and strategies. Adv Drug Deliv Rev. 81:128–141. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yu T, Liang S, Ma T and Song W: Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma. Exp Ther Med 21: 592, 2021.
APA
Yu, T., Liang, S., Ma, T., & Song, W. (2021). Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma. Experimental and Therapeutic Medicine, 21, 592. https://doi.org/10.3892/etm.2021.10024
MLA
Yu, T., Liang, S., Ma, T., Song, W."Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma". Experimental and Therapeutic Medicine 21.6 (2021): 592.
Chicago
Yu, T., Liang, S., Ma, T., Song, W."Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma". Experimental and Therapeutic Medicine 21, no. 6 (2021): 592. https://doi.org/10.3892/etm.2021.10024
Copy and paste a formatted citation
x
Spandidos Publications style
Yu T, Liang S, Ma T and Song W: Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma. Exp Ther Med 21: 592, 2021.
APA
Yu, T., Liang, S., Ma, T., & Song, W. (2021). Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma. Experimental and Therapeutic Medicine, 21, 592. https://doi.org/10.3892/etm.2021.10024
MLA
Yu, T., Liang, S., Ma, T., Song, W."Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma". Experimental and Therapeutic Medicine 21.6 (2021): 592.
Chicago
Yu, T., Liang, S., Ma, T., Song, W."Downregulation of miR‑588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma". Experimental and Therapeutic Medicine 21, no. 6 (2021): 592. https://doi.org/10.3892/etm.2021.10024
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