Role of NGF and its receptors in wound healing (Review)
- Authors:
- Zhenxing Liu
- Haiwei Wu
- Shengyun Huang
-
Affiliations: Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China - Published online on: April 11, 2021 https://doi.org/10.3892/etm.2021.10031
- Article Number: 599
-
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
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|
Wang PH, Huang BS, Horng HC, Yeh CC and Chen YJ: Wound healing. J Chin Med Assoc. 81:94–101. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Ridiandries A, Tan JTM and Bursill CA: The role of chemokines in Wound healing. Int J Mol Sci. 19(3217)2018.PubMed/NCBI View Article : Google Scholar | |
|
Yasukawa K, Okuno T and Yokomizo T: Eicosanoids in skin Wound healing. Int J Mol Sci. 21(8435)2020.PubMed/NCBI View Article : Google Scholar | |
|
Zarei F and Soleimaninejad M: Role of growth factors and biomaterials in wound healing. Artif Cells Nanomed Biotechnol. 46:906–911. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Gostynska N, Pannella M, Rocco ML, Giardino L, Aloe L and Calza L: The pleiotropic molecule NGF regulates the in vitro properties of fibroblasts, keratinocytes, and endothelial cells: Implications for wound healing. Am J Physiol Cell Physiol. 318:C360–C371. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Lambiase A, Manni L, Bonini S, Rama P and Aloe L: Nerve growth factor promotes corneal healing: Structural, biochemical, and molecular analyses of rat and human corneas. Invest Ophthalmol Vis Sci. 41:1063–1069. 2000.PubMed/NCBI | |
|
Chen JC, Lin BB, Hu HW, Lin C, Jin WY, Zhang FB, Zhu YA, Lu CJ, Wei XJ and Chen RJ: NGF accelerates cutaneous wound healing by promoting the migration of dermal fibroblasts via the PI3K/Akt-Rac1-JNK and ERK pathways. Biomed Res Int. 2014(547187)2014.PubMed/NCBI View Article : Google Scholar | |
|
Ishikawa S, Takeda A, Akimoto M, Kounoike N, Uchinuma E and Uezono Y: Effects of neuropeptides and their local administration to cutaneous wounds in sensory-impaired areas. J Plast Surg Hand Surg. 48:143–147. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Liu Z, Cao Y, Liu G, Yin S, Ma J, Liu J, Zhang M and Wang Y: p75 neurotrophin receptor regulates NGF-induced myofibroblast differentiation and collagen synthesis through MRTF-A. Exp Cell Res. 383(111504)2019.PubMed/NCBI View Article : Google Scholar | |
|
Troullinaki M, Alexaki VI, Mitroulis I, Witt A, Klotzsche-von Ameln A, Chung KJ, Chavakis T and Economopoulou M: Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis. J Cell Mol Med. 23:2362–2371. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Tanigawa T, Ahluwalia A, Watanabe T, Arakawa T and Tarnawski AS: Nerve growth factor injected into the gastric ulcer base incorporates into endothelial, neuronal, glial and epithelial cells: Implications for angiogenesis, mucosal regeneration and ulcer healing. J Physiol Pharmacol. 66:617–621. 2015.PubMed/NCBI | |
|
Generini S, Tuveri MA, Matucci Cerinic M, Mastinu F, Manni L and Aloe L: Topical application of nerve growth factor in human diabetic foot ulcers. A study of three cases. Exp Clin Endocrinol Diabetes. 112:542–544. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Aloe L, Tirassa P and Lambiase A: The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers. Pharmacol Res. 57:253–258. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Cheret J, Lebonvallet N, Carre JL, Misery L and Le Gall-Ianotto C: Role of neuropeptides, neurotrophins, and neurohormones in skin wound healing. Wound Repair Regen. 21:772–788. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Kanu LN and Ciolino JB: Nerve growth factor as an ocular therapy: Applications, challenges, and future directions. Semin Ophthalmol: 1-8, 2021 (Epub ahead of print). doi: 10.1080/08820538.2021.1890793. | |
|
Levi-Montalcini R and Angeletti PU: Nerve growth factor. Physiol Rev. 48:534–569. 1968.PubMed/NCBI View Article : Google Scholar | |
|
Levi-Montalcini R: The nerve growth factor 35 years later. Science. 237:1154–1162. 1987.PubMed/NCBI View Article : Google Scholar | |
|
Sun HL and Jiang T: The structure of nerve growth factor in complex with lysophosphatidylinositol. Acta Crystallogr F Struct Biol Commun. 71:906–912. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Varon S, Nomura J and Shooter EM: The isolation of the mouse nerve growth factor protein in a high molecular weight form. Biochemistry. 6:2202–2209. 1967.PubMed/NCBI View Article : Google Scholar | |
|
Smith AP, Varon S and Shooter EM: Multiple forms of the nerve growth factor protein and its subunits. Biochemistry. 7:3259–3268. 1968.PubMed/NCBI View Article : Google Scholar | |
|
Wiesmann C and de Vos AM: Nerve growth factor: Structure and function. Cell Mol Life Sci. 58:748–759. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Angeletti RH and Bradshaw RA: Nerve growth factor from mouse submaxillary gland: Amino acid sequence. Proc Natl Acad Sci USA. 68:2417–2420. 1971.PubMed/NCBI View Article : Google Scholar | |
|
Sofroniew MV, Howe CL and Mobley WC: Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 24:1217–1281. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Seidah NG, Benjannet S, Pareek S, Savaria D, Hamelin J, Goulet B, Laliberte J, Lazure C, Chrétien M and Murphy RA: Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. Biochem J. 314:951–960. 1996.PubMed/NCBI View Article : Google Scholar | |
|
Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L and Leon A: Nerve growth factor: From neurotrophin to neurokine. Trends Neurosci. 19:514–520. 1996.PubMed/NCBI View Article : Google Scholar | |
|
Lewin GR and Barde YA: Physiology of the neurotrophins. Ann Rev Neurosci. 19:289–317. 1996.PubMed/NCBI View Article : Google Scholar | |
|
Micera A, Puxeddu I, Aloe L and Levi-Schaffer F: New insights on the involvement of Nerve Growth Factor in allergic inflammation and fibrosis. Cytokine Growth Factor Rev. 14:369–374. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Micera A, Lambiase A, Aloe L and Bonini S, Levi-Schaffer F and Bonini S: Nerve growth factor involvement in the visual system: Implications in allergic and neurodegenerative diseases. Cytokine Growth Factor Rev. 15:411–417. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Lambiase A, Micera A, Sgrulletta R and Bonini S and Bonini S: Nerve growth factor and the immune system: Old and new concepts in the cross-talk between immune and resident cells during pathophysiological conditions. Curr Opin Allergy Clin Immunol. 4:425–430. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Hondermarck H: Neurotrophins and their receptors in breast cancer. Cytokine Growth Factor Rev. 23:357–365. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Dahlström M, Nordvall G, Sundström E, Åkesson E, Tegerstedt G, Eriksdotter M and Forsell P: Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons. Eur J Neurosci. 50:3487–3501. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Rocco ML, Soligo M, Manni L and Aloe L: Nerve growth factor: Early studies and recent clinical trials. Curr Neuropharmacol. 16:1455–1465. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Aloe L, Rocco ML, Balzamino BO and Micera A: Nerve growth factor: Role in growth, differentiation and controlling cancer cell development. J Exp Clin Cancer Res. 35(116)2016.PubMed/NCBI View Article : Google Scholar | |
|
Skaper SD: Nerve growth factor: A neuroimmune crosstalk mediator for all seasons. Immunology. 151:1–15. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Capsoni S, Brandi R, Arisi I, D'Onofrio M and Cattaneo A: A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model. CNS Neurol Disord Drug Targets. 10:635–647. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Bracci-Laudiero L and De Stefano ME: NGF in early embryogenesis, differentiation, and pathology in the nervous and immune systems. In: Neurotoxin Modeling of Brain Disorders-Life-long Outcomes in Behavioral Teratology. pp125-152, 2015. | |
|
Niederhauser O, Mangold M, Schubenel R, Kusznir EA, Schmidt D and Hertel C: NGF ligand alters NGF signaling via p75(NTR) and TrkA. J Neurosci Res. 61:263–272. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Kawamoto K and Matsuda H: Nerve growth factor and wound healing. In: NGF and Related Molecules in Health and Disease. pp369-384, 2004. | |
|
Tomellini E, Touil Y, Lagadec C, Julien S, Ostyn P, Ziental-Gelus N, Meignan S, Lengrand J, Adriaenssens E, Polakowska R and Le Bourhis X: Nerve growth factor and proNGF simultaneously promote symmetric self-renewal, quiescence, and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment. Stem Cells. 33:342–353. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Steckiewicz KP, Barcińska E and Woźniak M: Nerve growth factor as an important possible component of novel therapy for cancer, diabetes and cardiovascular diseases. Cell Mol Biol (Noisy-le-Grand). 64:16–23. 2018.PubMed/NCBI | |
|
Rowe CW, Dill T, Faulkner S, Gedye C, Paul JW, Tolosa JM, Jones M, King S, Smith R and Hondermarck H: The precursor for nerve growth factor (proNGF) in thyroid cancer lymph node metastases: Correlation with primary tumour and pathological variables. Int J Mol Sci. 20(5924)2019.PubMed/NCBI View Article : Google Scholar | |
|
Rowe CW, Faulkner S, Paul JW, Tolosa JM, Gedye C, Bendinelli C, Wynne K, McGrath S, Attia J, Smith R and Hondermarck H: The precursor for nerve growth factor (proNGF) is not a serum or biopsy-rinse biomarker for thyroid cancer diagnosis. BMC Endocr Disord. 19(128)2019.PubMed/NCBI View Article : Google Scholar | |
|
Lad SP, Peterson DA, Bradshaw RA and Neet KE: Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site. J Biol Chem. 278:24808–24817. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Meakin SO and Shooter EM: The nerve growth factor family of receptors. Trends Neurosci. 15:323–331. 1992.PubMed/NCBI View Article : Google Scholar | |
|
Frade JM and Barde YA: Nerve growth factor: Two receptors, multiple functions. Bioessays. 20:137–145. 1998.PubMed/NCBI View Article : Google Scholar | |
|
Weier HU, Rhein AP, Shadravan F, Collins C and Polikoff D: Rapid physical mapping of the human trk protooncogene (NTRK1) to human chromosome 1q21-q22 by P1 clone selection, fluorescence in situ hybridization (FISH), and computer-assisted microscopy. Genomics. 26:390–393. 1995.PubMed/NCBI View Article : Google Scholar | |
|
Barbacid M: Structural and functional properties of the TRK family of neurotrophin receptors. Ann N Y Acad Sci. 766:442–458. 1995.PubMed/NCBI View Article : Google Scholar | |
|
Wiesmann C, Ultsch MH, Bass SH and de Vos AM: Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 401:184–188. 1999.PubMed/NCBI View Article : Google Scholar | |
|
Urfer R, Tsoulfas P, O'Connell L, Hongo JA, Zhao W and Presta LG: High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors. J Biol Chem. 273:5829–5840. 1998.PubMed/NCBI View Article : Google Scholar | |
|
Kassel O, de Blay F, Duvernelle C, Olgart C, Israel-Biet D, Krieger P, Moreau L, Muller C, Pauli G and Frossard N: Local increase in the number of mast cells and expression of nerve growth factor in the bronchus of asthmatic patients after repeated inhalation of allergen at low-dose. Clin Exp Allergy. 31:1432–1440. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Zheng MG, Sui WY, He ZD, Liu Y, Huang YL, Mu SH, Xu XZ, Zhang JS, Qu JL, Zhang J, et al: TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts. Neural Regen Res. 14:1765–1771. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Zhang M, Zhang Y, Ding J, Li X, Zang C, Yin S, Ma J, Wang Y and Cao Y: The role of TrkA in the promoting wounding-healing effect of CD271 on epidermal stem cells. Arch Dermatol Res. 310:737–750. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Freund-Michel V and Frossard N: The nerve growth factor and its receptors in airway inflammatory diseases. Pharmacol Ther. 117:52–76. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Reichardt LF: Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 361:1545–1564. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Micera A, Lambiase A, Stampachiacchiere B, Bonini S, Bonini S and Levi-Schaffer F: Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate. Cytokine Growth Factor Rev. 18:245–256. 2007.PubMed/NCBI View Article : Google Scholar | |
|
Faulkner S, Jobling P, Rowe CW, Rodrigues Oliveira SM, Roselli S, Thorne RF, Oldmeadow C, Attia J, Jiang CC, Zhang XD, et al: Neurotrophin receptors TrkA, p75NTR, and sortilin are increased and targetable in thyroid cancer. Am J Pathol. 188:229–241. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL and Hondermarck H: NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling. Adv Biol Regul. 58:16–27. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Huber LJ and Chao MV: A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immunoprecipitation. J Neurosci Res. 40:557–563. 1995.PubMed/NCBI View Article : Google Scholar | |
|
Huebner K, Isobe M, Chao M, Bothwell M, Ross AH, Finan J, Hoxie JA, Sehgal A, Buck CR, Lanahan A, et al: The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias. Proc Natl Acad Sci USA. 83:1403–1407. 1986.PubMed/NCBI View Article : Google Scholar | |
|
Roux P: Neurotrophin signaling through the p75 neurotrophin receptor. Progress Neurobiol. 67:203–233. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Yan H and Chao MV: Disruption of cysteine-rich repeats of the p75 nerve growth factor receptor leads to loss of ligand binding. J Biol Chem. 266:12099–12104. 1991.PubMed/NCBI | |
|
Baldwin AN, Bitler CM, Welcher AA and Shooter EM: Studies on the structure and binding properties of the cysteine-rich domain of rat low affinity nerve growth factor receptor (p75NGFR). J Biol Chem. 267:8352–8359. 1992.PubMed/NCBI | |
|
Pincelli C: p75 neurotrophin receptor in the skin: Beyond its neurotrophic function. Front Med (Lausanne). 4(22)2017.PubMed/NCBI View Article : Google Scholar | |
|
Chao MV, Bothwell MA, Ross AH, Koprowski H, Lanahan AA, Buck CR and Sehgal A: Gene transfer and molecular cloning of the human NGF receptor. Science. 232:518–521. 1986.PubMed/NCBI View Article : Google Scholar | |
|
Shamovsky IL, Ross GM, Riopelle RJ and Weaver DF: The interaction of neurotrophins with the p75NTR common neurotrophin receptor: A comprehensive molecular modeling study. Protein Sci. 8:2223–2233. 1999.PubMed/NCBI View Article : Google Scholar | |
|
He XL and Garcia KC: Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science. 304:870–875. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Meeker R and Williams K: Dynamic nature of the p75 neurotrophin receptor in response to injury and disease. J Neuroimmune Pharmacol. 9:615–628. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Barker PA: p75NTR is positively promiscuous: Novel partners and new insights. Neuron. 42:529–533. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Chao MV: Neurotrophins and their receptors: A convergence point for many signalling pathways. Nat Rev Neurosci. 4:299–309. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, et al: ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci. 25:5455–5463. 2005.PubMed/NCBI View Article : Google Scholar | |
|
Skaper SD: The neurotrophin family of neurotrophic factors: An overview. Methods Mol Biol. 846:1–12. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Lee R, Kermani P, Teng KK and Hempstead BL: Regulation of cell survival by secreted proneurotrophins. Science. 294:1945–1948. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Beattie MS, Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL and Yoon SO: ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 36:375–386. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Domeniconi M, Hempstead BL and Chao MV: Pro-NGF secreted by astrocytes promotes motor neuron cell death. Mol Cell Neurosci. 34:271–279. 2007.PubMed/NCBI View Article : Google Scholar | |
|
Dechant G and Barde YA: The neurotrophin receptor p75(NTR): Novel functions and implications for diseases of the nervous system. Nat Neurosci. 5:1131–1136. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Roosterman D, Goerge T, Schneider SW, Bunnett NW and Steinhoff M: Neuronal control of skin function: The skin as a neuroimmunoendocrine organ. Physiol Rev. 86:1309–1379. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Sorg H, Tilkorn DJ, Hager S, Hauser J and Mirastschijski U: Skin wound healing: An update on the current knowledge and concepts. Eur Surg Res. 58:81–94. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Marconi A, Terracina M, Fila C, Franchi J, Bonté F, Romagnoli G, Maurelli R, Failla CM, Dumas M and Pincelli C: Expression and function of neurotrophins and their receptors in cultured human keratinocytes. J Invest Dermatol. 121:1515–1521. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Pincelli C, Sevignani C, Manfredini R, Grande A, Fantini F, Bracci-Laudiero L, Aloe L, Ferrari S, Cossarizza A and Giannetti A: Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J Invest Dermatol. 103:13–18. 1994.PubMed/NCBI View Article : Google Scholar | |
|
Murase K, Murakami Y, Takayanagi K, Furukawa Y and Hayashi K: Human fibroblast cells synthesize and secrete nerve growth factor in culture. Biochem Biophys Res Commun. 184:373–379. 1992.PubMed/NCBI View Article : Google Scholar | |
|
Tron VA, Coughlin MD, Jang DE, Stanisz J and Sauder DN: Expression and modulation of nerve growth factor in murine keratinocytes (PAM 212). J Clin Invest. 85:1085–1089. 1990.PubMed/NCBI View Article : Google Scholar | |
|
Hefti F: Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J Neurosci. 6:2155–2162. 1986.PubMed/NCBI View Article : Google Scholar | |
|
Hefti F, Dravid A and Hartikka J: Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions. Brain Res. 293:305–311. 1984.PubMed/NCBI View Article : Google Scholar | |
|
Manni L, Rocco ML, Bianchi P, Soligo M, Guaragna M, Barbaro SP and Aloe L: Nerve growth factor: Basic studies and possible therapeutic applications. Growth Factors. 31:115–122. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Minnone G, De Benedetti F and Bracci-Laudiero L: NGF and its receptors in the regulation of inflammatory response. Int J Mol Sci. 18(1028)2017.PubMed/NCBI View Article : Google Scholar | |
|
Raychaudhuri SK, Raychaudhuri SP, Weltman H and Farber EM: Effect of nerve growth factor on endothelial cell biology: Proliferation and adherence molecule expression on human dermal microvascular endothelial cells. Arch Dermatol Res. 293:291–295. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Matsuda H, Koyama H, Sato H, Sawada J, Itakura A, Tanaka A, Matsumoto M, Konno K, Ushio H and Matsuda K: Role of nerve growth factor in cutaneous wound healing: Accelerating effects in normal and healing-impaired diabetic mice. J Exp Med. 187:297–306. 1998.PubMed/NCBI View Article : Google Scholar | |
|
Li AK, Koroly MJ, Schattenkerk ME, Malt RA and Young M: Nerve growth factor: Acceleration of the rate of wound healing in mice. Proc Natl Acad Sci USA. 77:4379–4381. 1980.PubMed/NCBI View Article : Google Scholar | |
|
Nakagaki O, Miyoshi H, Sawada T and Atsumi T, Kondo T and Atsumi T: Epalrestat improves diabetic wound healing via increased expression of nerve growth factor. Exp Clin Endocrinol Diabetes. 121:84–89. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Ali Bahar M, Bauer B, Tredget EE and Ghahary A: Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA. Wound Repair Regen. 12:175–182. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Anand P, Terenghi G, Warner G, Kopelman P, Williams-Chestnut RE and Sinicropi DV: The role of endogenous nerve growth factor in human diabetic neuropathy. Nat Med. 2:703–707. 1996.PubMed/NCBI View Article : Google Scholar | |
|
Shi CM, Qu JF and Cheng TM: Effects of the nerve growth factor on the survival and wound healing in mice with combined radiation and wound injury. J Radiat Res. 44:223–228. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Bernabei R, Landi F, Bonini S, Onder G, Lambiase A, Pola R and Aloe L: Effect of topical application of nerve-growth factor on pressure ulcers. Lancet. 354(307)1999.PubMed/NCBI View Article : Google Scholar | |
|
Landi F, Aloe L, Russo A, Cesari M, Onder G, Bonini S, Carbonin PU and Bernabei R: Topical treatment of pressure ulcers with nerve growth factor: A randomized clinical trial. Ann Intern Med. 139:635–641. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Coelho S, Amarelo M, Ryan S, Reddy M and Sibbald RG: Rheumatoid arthritis-associated inflammatory leg ulcers: A new treatment for recalcitrant wounds. Int Wound J. 1:81–84. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Tuveri M, Generini S, Matucci-Cerinic M and Aloe L: NGF, a useful tool in the treatment of chronic vasculitic ulcers in rheumatoid arthritis. Lancet. 356:1739–1740. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Ashrafi M, Baguneid M and Bayat A: The role of neuromediators and innervation in cutaneous wound healing. Acta Derm Venereol. 96:587–594. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Aloe L, Tirassa P and Bracci-Laudiero L: Nerve growth factor in neurological and non-neurological diseases: Basic findings and emerging pharmacological prospectives. Curr Pharm Des. 7:113–123. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Burbach GJ, Kim KH, Zivony AS, Kim A, Aranda J, Wright S, Naik SM, Caughman SW, Ansel JC and Armstrong CA: The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor. J Invest Dermatol. 117:1075–1082. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Gibran NS, Tamura R, Tsou R and Isik FF: Human dermal microvascular endothelial cells produce nerve growth factor: Implications for wound repair. Shock. 19:127–130. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Bowles WR, Sabino M, Harding-Rose C and Hargreaves KM: Chronic nerve growth factor administration increases the peripheral exocytotic activity of capsaicin-sensitive cutaneous neurons. Neurosci Lett. 403:305–308. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Banks BEC, Vernon CA and Warner JA: Nerve growth factor has anti-inflammatory activity in the rat hindpaw oedema test. Neurosci Lett. 47:41–45. 1984.PubMed/NCBI View Article : Google Scholar | |
|
Emanueli C, Salis MB, Pinna A, Graiani G, Manni L and Madeddu P: Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs. Circulation. 106:2257–2262. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Zhang M, Cao Y, Li X, Hu L, Taieb SK, Zhu X, Zhang J, Feng Y, Zhao R, Wang M, et al: Cd271 mediates proliferation and differentiation of epidermal stem cells to support cutaneous burn wound healing. Cell Tissue Res. 371:273–282. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Wilson SE: Corneal wound healing. Exp Eye Res. 197(108089)2020.PubMed/NCBI View Article : Google Scholar | |
|
Spadea L, Giammaria D and Trabucco P: Corneal wound healing after laser vision correction. Br J Ophthalmol. 100:28–33. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Wilson SE, Mohan RR, Mohan RR, Ambrósio R, Hong J and Lee J: The corneal wound healing response. Progress Retinal Eye Res. 20:625–637. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Agrawal VB and Tsai RJ: Corneal epithelial wound healing. Indian J Ophthalmol. 51:5–15. 2003.PubMed/NCBI | |
|
Lambiase A, Manni L, Bonini S, Rama P and Aloe L: Nerve growth factor promotes corneal healing: Structural, biochemical, and molecular analyses of rat and human corneas. Invest Ophthalmol Vis Sci. 41:1063–1069. 2000.PubMed/NCBI | |
|
You L, Kruse FE and Völcker HE: Neurotrophic factors in the human cornea. Invest Ophthalmol Vis Sci. 41:692–702. 2000.PubMed/NCBI | |
|
Lambiase A, Bonini S, Micera A, Magrini L and Aloe L: Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. Invest Ophthalmol Vis Sci. 36:2127–2132. 1995.PubMed/NCBI | |
|
Cellini M, Bendo E, Bravetti GO and Campos EC: The use of nerve growth factor in surgical wound healing of the cornea. Ophthalmic Res. 38:177–181. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Blanco-Mezquita T, Martinez-Garcia C, Proenca R, Zieske JD, Bonini S, Lambiase A and Merayo-Lloves J: Nerve growth factor promotes corneal epithelial migration by enhancing expression of matrix metalloprotease-9. Invest Ophthalmol Vis Sci. 54:3880–3890. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Touhami A, Grueterich M and Tseng SC: The role of NGF signaling in human limbal epithelium expanded by amniotic membrane culture. Invest Ophthalmol Vis Sci. 43:987–994. 2002.PubMed/NCBI | |
|
Matsuyama A, Takatori S, Sone Y, Ochi E, Goda M, Zamami Y, Hashikawa-Hobara N, Kitamura Y and Kawasaki H: Effect of nerve growth factor on innervation of perivascular nerves in neovasculatures of mouse cornea. Biol Pharm Bull. 40:396–401. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Seo K, Choi J, Park M and Rhee C: Angiogenesis effects of nerve growth factor (NGF) on rat corneas. J Vet Sci. 2:125–130. 2001.PubMed/NCBI | |
|
Lambiase A, Sacchetti M and Bonini S: Nerve growth factor therapy for corneal disease. Curr Opin Ophthalmol. 23:296–302. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Larjava H: Oral Wound Healing: An Overview. John Wiley & Sons, Ltd, 2013. | |
|
Nauta A, Gurtner G and Longaker MT: Wound healing and regenerative strategies. Oral Dis. 17:541–549. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Chin GS, Kim WJ, Lee TY, Liu W, Saadeh PB, Lee S, Levinson H, Gittes GK and Longaker MT: Differential expression of receptor tyrosine kinases and Shc in fetal and adult rat fibroblasts: Toward defining scarless versus scarring fibroblast phenotypes. Plast Reconstr Surg. 105:972–979. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Chen L, Arbieva ZH, Guo S, Marucha PT, Mustoe TA and DiPietro LA: Positional differences in the wound transcriptome of skin and oral mucosa. BMC Genomics. 11(471)2010.PubMed/NCBI View Article : Google Scholar | |
|
Hayashi K, Karatsaidis A, Schreurs O, Bjornland T, Sugisaki M and Schenck K: NGF and its receptors TrkA and p75NTR in the epithelium of oral lichen. J Oral Pathol Med. 37:241–248. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Naesse EP, Schreurs O, Messelt E, Hayashi K and Schenck K: Distribution of nerve growth factor, pro-nerve growth factor, and their receptors in human salivary glands. Eur J Oral Sci. 121:13–20. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Hayashi K, Storesund T, Schreurs O, Khuu C, Husvik C, Karatsaidis A, Helgeland K, Martin-Zanca D and Schenck K: Nerve growth factor beta/pro-nerve growth factor and their receptors in normal human oral mucosa. Eur J Oral Sci. 115:344–354. 2007.PubMed/NCBI View Article : Google Scholar | |
|
Schenck K, Schreurs O, Hayashi K and Helgeland K: The role of nerve growth factor (NGF) and its precursor forms in oral wound healing. Int J Mol Sci. 18(386)2017.PubMed/NCBI View Article : Google Scholar | |
|
Bruno MA and Cuello AC: Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. Proc Natl Acad Sci USA. 103:6735–6740. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Tan L, Hatzirodos N and Wormald PJ: Effect of nerve growth factor and keratinocyte growth factor on wound healing of the sinus mucosa. Wound Repair Regen. 16:108–116. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Bonini S, Rasi G, Bracci-Laudiero ML, Procoli A and Aloe L: Nerve growth factor: Neurotrophin or cytokine? Int Arch Allergy Immunol. 131:80–84. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Samah B, Porcheray F and Gras G: Neurotrophins modulate monocyte chemotaxis without affecting macrophage function. Clin Exp Immunol. 151:476–486. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Palazzo E, Marconi A, Truzzi F, Dallaglio K, Petrachi T, Humbert P, Schnebert S, Perrier E, Dumas M and Pincelli C: Role of neurotrophins on dermal fibroblast survival and differentiation. J Cell Physiol. 227:1017–1025. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Darby IA, Zakuan N, Billet F and Desmouliere A: The myofibroblast, a key cell in normal and pathological tissue repair. Cell Mol Life Sci. 73:1145–1157. 2016.PubMed/NCBI View Article : Google Scholar |
