Open Access

Role of NGF and its receptors in wound healing (Review)

  • Authors:
    • Zhenxing Liu
    • Haiwei Wu
    • Shengyun Huang
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  • Published online on: April 11, 2021     https://doi.org/10.3892/etm.2021.10031
  • Article Number: 599
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Wound healing is an important and complicated process that includes four highly integrated and overlapping phases, haemostasis, inflammation, proliferation and tissue remodelling. Nerve growth factor (NGF) was the first member of a family of neurotrophic factors to be discovered, and is an essential neurotrophic factor for the development and maintenance of the central and peripheral nervous systems. Several studies have proposed that NGF and its receptors, tropomyosin‑related kinase receptor 1 and NGF receptor, are involved in the wound healing process, and are important components of the healing of several wounds both in vivo and in vitro. Topical application of NGF significantly promotes the healing of different types of wounds, including diabetic foot ulcers, pressure ulcers and corneal wounds. The present review summarizes the status of NGF and its receptors in current literature, and discusses data obtained in the last few years on the healing action of NGF in cutaneous, corneal and oral wounds.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu Z, Wu H and Huang S: Role of NGF and its receptors in wound healing (Review). Exp Ther Med 21: 599, 2021.
APA
Liu, Z., Wu, H., & Huang, S. (2021). Role of NGF and its receptors in wound healing (Review). Experimental and Therapeutic Medicine, 21, 599. https://doi.org/10.3892/etm.2021.10031
MLA
Liu, Z., Wu, H., Huang, S."Role of NGF and its receptors in wound healing (Review)". Experimental and Therapeutic Medicine 21.6 (2021): 599.
Chicago
Liu, Z., Wu, H., Huang, S."Role of NGF and its receptors in wound healing (Review)". Experimental and Therapeutic Medicine 21, no. 6 (2021): 599. https://doi.org/10.3892/etm.2021.10031