Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2021 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2021 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies

  • Authors:
    • Iuliana Sobaru Mohorea
    • Bogdan Socea
    • Dragoş Şerban
    • Zenaida Ceausu
    • Adrian Tulin
    • Violeta Melinte
    • Mihai Ceausu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Pathology, ‘Sf. Pantelimon’ Emergency Hospital, 021659 Bucharest, Romania, Department of Anatomy, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Infectious Diseases, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Copyright: © Mohorea et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 607
    |
    Published online on: April 14, 2021
       https://doi.org/10.3892/etm.2021.10039
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Thyroid cancer accounts for 1% of all malignancies, and is becoming increasingly common worldwide. The literature reports a prevalence of ~50% of thyroid nodules detected during autopsies in subjects with unknown thyroid pathology. An extended retrospective study of 526 autopsy cases was performed to identify the prevalence of thyroid carcinoma, among various types of thyroid nodules identified incidentally. Tissue samples were taken from thyroid nodules, for investigation of the presence of thyroid carcinoma, along with their macroscopic and microscopic features by means of histopathology and immunohistochemistry (IHC) methods. Histopathological diagnosis of malignancy was found in 51 cases of analyzed thyroid samples. Systematic detailed studies demonstrated that a thyroid gland, apparently normal on macroscopic examination, may be the site of pathological manifestations, sometimes presenting carcinomatous findings. Among thyroid carcinomas, the highest frequency was that of papillary microcarcinomas, which have a long evolution, and are incidentally detected during autopsies. Papillary microcarcinoma is an extremely common incidental finding and the vast majority of these tumors pursue a benign course. Furthermore, it is therefore necessary to create national screening programs for the early detection of thyroid carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Pezzolla A, Lattarulo S, Milella M, Barile G, Pascazio B, Ciampolillo A, Fabiano G and Palasciano N: Incidental carcinoma in thyroid pathology: Our experience and review of the literature. Ann Ital Chir. 81:165–169. 2010.PubMed/NCBI

2 

Hurtado-López LM, Basurto-Kuba E, Montes de Oca-Durán ER, Pulido-Cejudo A, Vázquez-Ortega R and Athié-Gutiérrez C: Prevalence of thyroid nodules in the valley of Mexico. Cir Cir. 79:114–117. 2011.PubMed/NCBI

3 

Ramirez-Gonzalez LR, Sevilla-Vizcaino R, Monge-Reyes P, Aldaz-Dorantes JE, Márquez-Valdez AR, García-Martínez D, González-Ojeda A and Fuentes-Orozco C: Findings of thyroid nodules in autopsies in western Mexico. Rev Med Inst Mex Seguro Soc. 55:594–598. 2017.PubMed/NCBI(In Spanish).

4 

Yu GP, Li JCL, Branovan D, McCormick S and Schantz SP: Thyroid cancer incidence and survival in the national cancer institute surveillance, epidemiology, and end results race/ethnicity groups. Thyroid. 20:465–473. 2010.PubMed/NCBI View Article : Google Scholar

5 

Park SY, Jung YS, Ryu CH, Lee CY, Lee YJ, Lee EK, Kim SK, Kim TS, Kim TH, Jang J, et al: Identification of occult tumors by whole-specimen mapping in solitary papillary thyroid carcinoma. Endocr Relat Cancer. 22:679–686. 2015.PubMed/NCBI View Article : Google Scholar

6 

Pinchera A: Thyroid incidentalomas. Horm Res. 68 (Suppl 5):S199–S201. 2007.PubMed/NCBI View Article : Google Scholar

7 

Vigneri R, Malandrino P and Vigneri P: The changing epidemiology of thyroid cancer: Why is incidence increasing? Curr Opin Oncol. 27:1–7. 2015.PubMed/NCBI View Article : Google Scholar

8 

Vaideeswar P, Singaravel S and Gupte P: The thyroid in ischemic heart disease: An autopsy study. Indian Heart J. 70 (Suppl 3):S489–S491. 2018.PubMed/NCBI View Article : Google Scholar

9 

Davies L, Morris LGT, Haymart M, Chen AY, Goldenberg D, Morris J, Ogilvie JB, Terris DJ, Netterville J, Wong RJ and Randolph G: AACE Endocrine Surgery Scientific Committee. American association of clinical endocrinologists and American college of endocrinology disease state clinical review: The increasing incidence of thyroid cancer. Endocr Pract. 21:686–696. 2015.PubMed/NCBI View Article : Google Scholar

10 

American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Cooper DS, Doherty GM, Haugen BR, Hauger BR, Kloos RT, et al: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid Off J Am Thyroid Association. 19:1167–1214. 2009.PubMed/NCBI View Article : Google Scholar

11 

Lee YS, Lim H, Chang HS and Park CS: Papillary thyroid microcarcinomas are different from latent papillary thyroid carcinomas at autopsy. J Korean Med Sci. 29:676–679. 2014.PubMed/NCBI View Article : Google Scholar

12 

Janovsky CCPS, Bittencourt MS, de Novais MAP, Maciel RMB, Biscolla RPM and Zucchi P: Thyroid cancer burden and economic impact on the Brazilian public health system. Arch Endocrinol Metab. 62:537–544. 2018.PubMed/NCBI View Article : Google Scholar

13 

Kaliszewski K, Zubkiewicz-Kucharska A, Kiełb P, Maksymowicz J, Krawczyk A and Krawiec O: Comparison of the prevalence of incidental and non-incidental papillary thyroid microcarcinoma during 2008-2016: A single-center experience. World J Surg Oncol. 16(202)2018.PubMed/NCBI View Article : Google Scholar

14 

Slijepcevic N, Zivaljevic V, Marinkovic J, Sipetic S, Diklic A and Paunovic I: Retrospective evaluation of the incidental finding of 403 papillary thyroid microcarcinomas in 2466 patients undergoing thyroid surgery for presumed benign thyroid disease. BMC Cancer. 15(330)2015.PubMed/NCBI View Article : Google Scholar

15 

Miyauchi A, Ito Y and Oda H: Insights into the management of papillary microcarcinoma of the thyroid. Thyroid. 28:23–31. 2018.PubMed/NCBI View Article : Google Scholar

16 

Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M, Sobrinho-Simoes M, et al: Poorly differentiated thyroid carcinoma: The turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach. Am J Surg Pathol. 31:1256–1264. 2007.PubMed/NCBI View Article : Google Scholar

17 

Shah JP: Thyroid carcinoma: Epidemiology, histology, and diagnosis. Clin Adv Hematol Oncol. 13 (Suppl 4):S3–S6. 2015.PubMed/NCBI

18 

Olson E, Wintheiser G, Wolfe KM, Droessler J and Silberstein PT: Epidemiology of thyroid cancer: A review of the national cancer database, 2000-2013. Cureus. 11(e4127)2019.PubMed/NCBI View Article : Google Scholar

19 

Lee I, Kim HK, Soh EY and Lee J: The association between chronic lymphocytic thyroiditis and the progress of papillary thyroid cancer. World J Surg. 44:1506–1513. 2020.PubMed/NCBI View Article : Google Scholar

20 

Shvero J, Koren R, Shpitzer T, Feinmesser R and Segal K: Immunohistochemical profile and treatment of uncommon types of thyroid carcinomas. Oncol Rep. 10:2075–2078. 2003.PubMed/NCBI View Article : Google Scholar

21 

Cvejic D, Savin S, Petrovic I, Selemetjev S, Paunovic I, Tatic S and Havelka M: Galectin-3 and proliferating cell nuclear antigen (PCNA) expression in papillary thyroid carcinoma. Exp Oncol. 27:210–214. 2005.PubMed/NCBI

22 

Brigante G, Monzani ML, Locaso M, Gnarini VL, Graziadei L, Kaleci S, De Santis MC, Tagliavini S, Simoni M, Rochira V and Madeo B: De novo lesions frequently develop in adult normal thyroid over almost six years. Front Endocrinol (Lausanne). 11(18)2020.PubMed/NCBI View Article : Google Scholar

23 

Dean DS and Gharib H: Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab. 22:901–911. 2008.PubMed/NCBI View Article : Google Scholar

24 

Ito Y, Miyauchi A and Oda H: Low-risk papillary microcarcinoma of the thyroid: A review of active surveillance trials. Eur J Surg Oncol. 44:307–315. 2018.PubMed/NCBI View Article : Google Scholar

25 

Gaman MA, Dobrica EC, Pascu EG, Cozma MA, Epingeac ME, Gaman AM, Pantea Stoian A, Bratu OG and Diaconu CC: Cardio metabolic risk factors for atrial fibrillation in type 2 diabetes mellitus: Focus on hypertension, metabolic syndrome and obesity. J Mind Med Sci. 6:157–161. 2019.

26 

Epingeac ME, Gaman MA, Diaconu C, Gad M and Gaman AM: The evaluation of oxidative stress levels in obesity. Rev Chim (Bucharest). 70:2241–2244. 2019.

27 

Zimmermann MB and Galetti V: Iodine intake as a risk factor for thyroid cancer: A comprehensive review of animal and human studies. Thyroid Res. 8(8)2015.PubMed/NCBI View Article : Google Scholar

28 

Haymart MR, Cayo M and Chen H: Papillary thyroid microcarcinomas: Big decisions for a small tumor. Ann Surg Oncol. 16:3132–3139. 2009.PubMed/NCBI View Article : Google Scholar

29 

Girardi FM, Barra MB and Zettler CG: Analysis of pattern of occurrence of thyroid carcinoma between 2001 and 2010. Braz J Otorhinolaryngol. 81:541–548. 2015.PubMed/NCBI View Article : Google Scholar

30 

Pai SA: The Washington manual of surgical pathology. J Clin Pathol. 62:766–767. 2009.

31 

Dumitru N, Cocolos A, Caragheorgheopol A, Dumitrache C, Bratu OG, Neagu TP, Diaconu CC and Ghemigian A: Collagen-the ultrastructural element of the bone matrix. Rev Chim (Bucharest). 69:1706–1709. 2018.

32 

Oda H, Miyauchi A, Ito Y, Yoshioka K, Nakayama A, Sasai H, Masuoka H, Yabuta T, Fukushima M, Higashiyama T, et al: Incidences of unfavorable events in the management of low-risk papillary microcarcinoma of the thyroid by active surveillance versus immediate surgery. Thyroid. 26:150–155. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mohorea IS, Socea B, Şerban D, Ceausu Z, Tulin A, Melinte V and Ceausu M: Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies. Exp Ther Med 21: 607, 2021.
APA
Mohorea, I.S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., & Ceausu, M. (2021). Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies. Experimental and Therapeutic Medicine, 21, 607. https://doi.org/10.3892/etm.2021.10039
MLA
Mohorea, I. S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., Ceausu, M."Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies". Experimental and Therapeutic Medicine 21.6 (2021): 607.
Chicago
Mohorea, I. S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., Ceausu, M."Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies". Experimental and Therapeutic Medicine 21, no. 6 (2021): 607. https://doi.org/10.3892/etm.2021.10039
Copy and paste a formatted citation
x
Spandidos Publications style
Mohorea IS, Socea B, Şerban D, Ceausu Z, Tulin A, Melinte V and Ceausu M: Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies. Exp Ther Med 21: 607, 2021.
APA
Mohorea, I.S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., & Ceausu, M. (2021). Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies. Experimental and Therapeutic Medicine, 21, 607. https://doi.org/10.3892/etm.2021.10039
MLA
Mohorea, I. S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., Ceausu, M."Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies". Experimental and Therapeutic Medicine 21.6 (2021): 607.
Chicago
Mohorea, I. S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., Ceausu, M."Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies". Experimental and Therapeutic Medicine 21, no. 6 (2021): 607. https://doi.org/10.3892/etm.2021.10039
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team