Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2021 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2021 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1

  • Authors:
    • Mengmeng Wang
    • Xiaoman Liu
    • Yu Wu
    • Yi Wang
    • Jiahui Cui
    • Jing Sun
    • Ying Bai
    • Ming-Fei Lang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Affiliated Xinhua Hospital of Dalian University, Dalian, Liaoning 116021, P.R. China, Medical College, Institute of Microanalysis, Dalian University, Dalian, Liaoning 116622, P.R. China, College of Environmental and Chemical Engineering, Institute of Microanalysis, Dalian University, Dalian, Liaoning 116622, P.R. China
  • Article Number: 616
    |
    Published online on: April 14, 2021
       https://doi.org/10.3892/etm.2021.10048
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The protection of brain tissue against damage and the reduction of infarct size is crucial for improving patient prognosis following ischemic stroke. Therefore, the present study aimed to investigate the regulatory effect of microRNA (miR)‑122 and its target gene repressor of RNA polymerase III transcription MAF1 homolog (Maf1) on the infarct area in ischemic stroke. Reverse transcription-quantitative PCR (RT‑qPCR) was performed to determine miR‑122 expression levels in an ischemic stroke [middle cerebral artery occlusion (MCAO)] mouse model. Nissl staining was conducted to measure the infarct area of the MCAO mouse model. Moreover, RT‑qPCR was performed to investigate the relationship between the expression of Maf1 and miR‑122 in the MCAO mouse model. Dual‑luciferase reporter assay in vitro and miR‑122 mimic or inhibitor treatment in vivo were conducted to verify that miR‑122 targeted and inhibited Maf1 expression. The results suggested that miR‑122 was upregulated in the brain tissue of MCAO model mice. miR‑122 overexpression effectively reduced the size of the infarct area in comparison with a control and miR‑122 knockdown in brain tissue resulted in the opposite effect. Moreover, Maf1 was confirmed to be a direct target of miR‑122. The results of a dual‑luciferase reporter assay indicated that miR‑122 bound to the 3'‑untranslated region of Maf1. Maf1 expression decreased after stroke model induction in comparison with that in sham animals, and Maf1 expression was negatively associated with the expression of miR‑122. In addition, miR‑122 knockdown increased Maf1 expression levels, whereas miR‑122 overexpression decreased Maf1 expression levels in comparison with a control. In conclusion, the results suggested that miR‑122 improved the outcome of acute ischemic stroke by reducing the expression of Maf1.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Zhou J, Chen L, Chen B, Huang S, Zeng C, Wu H, Chen C and Long F: Increased serum exosomal miR-134 expression in the acute ischemic stroke patients. BMC Neurol. 18(198)2018.PubMed/NCBI View Article : Google Scholar

2 

Zheng M, Wang X, Yang J, Ma S, Wei Y and Liu S: Changes of complement and oxidative stress parameters in patients with acute cerebral infarction or cerebral hemorrhage and the clinical significance. Exp Ther Med. 19:703–709. 2020.PubMed/NCBI View Article : Google Scholar

3 

Catanese L, Tarsia J and Fisher M: Acute ischemic stroke therapy overview. Circ Res. 120:541–558. 2017.PubMed/NCBI View Article : Google Scholar

4 

Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, Wu F, Chao J, Liu P, Hu G, et al: Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity. J Neurosci. 38:32–50. 2018.PubMed/NCBI View Article : Google Scholar

5 

Wang SW, Liu Z and Shi ZS: Non-Coding RNA in acute ischemic stroke: Mechanisms, biomarkers and therapeutic targets. Cell Transplant. 27:1763–1777. 2018.PubMed/NCBI View Article : Google Scholar

6 

Qi Z, Cai S, Cai J, Chen L, Yao Y, Chen L and Mao Y: miR-491 regulates glioma cells proliferation by targeting TRIM28 in vitro. BMC Neurol. 16(248)2016.PubMed/NCBI View Article : Google Scholar

7 

Qi R, Liu H and Liu C, Xu Y and Liu C: Expression and short-term prognostic value of miR-126 and miR-182 in patients with acute stroke. Exp Ther Med. 19:527–534. 2019.PubMed/NCBI View Article : Google Scholar

8 

Deng Y, Chen D, Gao F, Lv H, Zhang G, Sun X, Liu L, Mo D, Ma N, Song L, et al: Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via inhibition of LCN2. J Biol Eng. 13(71)2019.PubMed/NCBI View Article : Google Scholar

9 

Stanzione R, Bianchi F, Cotugno M, Marchitti S, Forte M, Busceti C, Ryskalin L, Fornai F, Volpe M and Rubattu S: A decrease of brain MicroRNA-122 level is an early marker of cerebrovascular disease in the stroke-prone spontaneously hypertensive rat. Oxid Med Cell Longev. 2017(1206420)2017.PubMed/NCBI View Article : Google Scholar

10 

Li DB, Liu JL, Wang W, Luo XM, Zhou X, Li JP, Cao XL, Long XH, Chen JG and Qin C: Plasma exosomal miRNA-122-5p and miR-300-3p as potential markers for transient ischaemic attack in rats. Front Aging Neurosci. 10(24)2018.PubMed/NCBI View Article : Google Scholar

11 

Gu R, Wang L, Tang M, Li SR, Liu R and Hu X: LncRNA Rpph1 protects amyloid-β induced neuronal injury in SK-N-SH cells via miR-122/Wnt1 axis. Int J Neurosci. 130:443–453. 2020.PubMed/NCBI View Article : Google Scholar

12 

Smith KR, Oliver PL, Lumb MJ, Arancibia-Carcamo IL, Revilla-Sanchez R, Brandon NJ, Moss SJ and Kittler JT: Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Mol Cell Neurosci. 44:330–341. 2010.PubMed/NCBI View Article : Google Scholar

13 

Shetty M, Noguchi C, Wilson S, Martinez E, Shiozaki K, Sell C, Mell JC and Noguchi E: Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan. Aging Cell. 19(e13068)2020.PubMed/NCBI View Article : Google Scholar

14 

Yamada D, Kawabe K, Tosa I, Tsukamoto S, Nakazato R, Kou M, Fujikawa K, Nakamura S, Ono M, Oohashi T, et al: Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system. Commun Biol. 2(346)2019.PubMed/NCBI View Article : Google Scholar

15 

Ma HX, Hou F, Chen AL, Li TT, Zhu YF and Zhao QP: Mu-Xiang-You-Fang protects PC12 cells against OGD/R-induced autophagy via the AMPK/mTOR signaling pathway. J Ethnopharmacol. 252(112583)2020.PubMed/NCBI View Article : Google Scholar

16 

Imai T, Iwata S, Miyo D, Nakamura S, Shimazawa M and Hara H: A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke models. J Pharmacol Sci. 141:119–126. 2019.PubMed/NCBI View Article : Google Scholar

17 

Gunawardena D, Raju R and Münch G: Hydrogen peroxide mediates pro-inflammatory cell-to-cell signaling: A new therapeutic target for inflammation. Neural Regen Res. 14:1430–1437. 2019.PubMed/NCBI View Article : Google Scholar

18 

Sies H: Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Redox Biol. 11:613–619. 2017.PubMed/NCBI View Article : Google Scholar

19 

Liu da Z, Jickling GC, Ander BP, Hull H, Zhan X, Cox C, Shroff N, Dykstra-Aiello C, Stamova B and Sharp FR: Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 36:1374–1383. 2016.PubMed/NCBI View Article : Google Scholar

20 

Tsang CK, Chen M, Cheng X, Qi Y, Chen Y, Das I, Li X, Vallat B, Fu LW, Qian CN, et al: SOD1 phosphorylation by mTORC1 couples nutrient sensing and redox regulation. Mol Cell. 70:502–515. 2018.PubMed/NCBI View Article : Google Scholar

21 

Liu BW, Luo C, Zheng ZG, Xia ZY, Zhang Q, Ke C, Liu R and Zhao YH: Shengui sansheng san extraction is an angiogenic switch via regulations of AKT/mTOR, ERK1/2 and Notch1 signal pathways after ischemic stroke. Phytomedicine. 44:20–31. 2018.PubMed/NCBI View Article : Google Scholar

22 

Hou YY, Wang K, Wan WJ, Cheng Y, Pu X and Ye XF: Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats. Genes Dis. 5:245–255. 2018.PubMed/NCBI View Article : Google Scholar

23 

Zhang SS, Li XX, Wang HY and Zheng XFS: Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer. Biochim Biophys Acta Gene Regul Mech. 1861:338–343. 2018.PubMed/NCBI View Article : Google Scholar

24 

National Research Council (US) Institute for Laboratory Animal Research: Guide for the Care and Use of Laboratory Animals. National Academies Press (US), Washington, DC, 1996.

25 

Llovera G, Roth S, Plesnila N, Veltkamp R and Liesz A: Modeling stroke in mice: Permanent coagulation of the distal middle cerebral artery. J Vis Exp. 31(e51729)2014.PubMed/NCBI View Article : Google Scholar

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

27 

Cheng X, Kan P, Ma Z, Wang Y, Song W, Huang C and Zhang B: Exploring the potential value of miR-148b-3p, miR-151b and miR-27b-3p as biomarkers in acute ischemic stroke. Biosci Rep. 38(BSR20181033)2018.PubMed/NCBI View Article : Google Scholar

28 

Si W, Ye S, Ren Z, Liu X, Wu Z, Li Y, Zhou J, Zhang S, Li Y, Deng R and Chen D: miR-335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke. Int J Mol Med. 43:1452–1466. 2019.PubMed/NCBI View Article : Google Scholar

29 

Liu W, Chen X and Zhang Y: Effects of microRNA-21 and microRNA-24 inhibitors on neuronal apoptosis in ischemic stroke. Am J Transl Res. 8:3179–3187. 2016.PubMed/NCBI

30 

Shi FP, Wang XH, Zhang HX, Shang MM, Liu XX, Sun HM and Song YP: MiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF). Iran J Basic Med Sci. 21:318–324. 2018.PubMed/NCBI View Article : Google Scholar

31 

Meng P, Zhu Q, Yang H, Liu D, Lin X, Liu J, Fan J, Liu X, Su W, Liu L, et al: Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR/SGK1 signaling pathway in cultured PC12 cells. Neuroreport. 30:247–254. 2019.PubMed/NCBI View Article : Google Scholar

32 

Cheng J, Tang JC, Pan MX, Chen SF, Zhao D, Zhang Y, Liao HB, Zhuang Y, Lei RX, Wang S, et al: l-lysine confers neuroprotection by suppressing inflammatory response via microRNA-575/PTEN signaling after mouse intracerebral hemorrhage injury. Exp Neurol. 327(113214)2020.PubMed/NCBI View Article : Google Scholar

33 

Du K, Zhao C, Wang L, Wang Y, Zhang KZ, Shen XY, Sun HX, Gao W and Lu X: MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1. Aging (Albany NY). 11:2762–2786. 2019.PubMed/NCBI View Article : Google Scholar

34 

Guo D, Ma J, Li T and Yan L: Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3. Exp Cell Res. 369:34–42. 2018.PubMed/NCBI View Article : Google Scholar

35 

Shi L, Zheng X, Fan Y, Yang X, Li A and Qian J: The contribution of miR-122 to the innate immunity by regulating toll-like receptor 4 in hepatoma cells. BMC Gastroenterol. 19(130)2019.PubMed/NCBI View Article : Google Scholar

36 

Xu H, Xu SJ, Xie SJ, Zhang Y, Yang JH, Zhang WQ, Zheng MN, Zhou H and Qu LH: MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. Elife. 8(e41159)2019.PubMed/NCBI View Article : Google Scholar

37 

Hatakeyama M, Ninomiya I and Kanazawa M: Angiogenesis and neuronal remodeling after ischemic stroke. Neural Regen Res. 15:16–19. 2020.PubMed/NCBI View Article : Google Scholar

38 

Jayaraj RL, Azimullah S, Beiram R, Jalal FY and Rosenberg GA: Neuroinflammation: Friend and foe for ischemic stroke. J Neuroinflammation. 16(142)2019.PubMed/NCBI View Article : Google Scholar

39 

Lv B, Cheng X, Sharp FR, Ander BP and Liu DZ: MicroRNA-122 mimic improves stroke outcomes and indirectly inhibits NOS2 after middle cerebral artery occlusion in rats. Front Neurosci. 12(767)2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang M, Liu X, Wu Y, Wang Y, Cui J, Sun J, Bai Y and Lang M: ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1. Exp Ther Med 21: 616, 2021.
APA
Wang, M., Liu, X., Wu, Y., Wang, Y., Cui, J., Sun, J. ... Lang, M. (2021). ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1. Experimental and Therapeutic Medicine, 21, 616. https://doi.org/10.3892/etm.2021.10048
MLA
Wang, M., Liu, X., Wu, Y., Wang, Y., Cui, J., Sun, J., Bai, Y., Lang, M."ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1". Experimental and Therapeutic Medicine 21.6 (2021): 616.
Chicago
Wang, M., Liu, X., Wu, Y., Wang, Y., Cui, J., Sun, J., Bai, Y., Lang, M."ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1". Experimental and Therapeutic Medicine 21, no. 6 (2021): 616. https://doi.org/10.3892/etm.2021.10048
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Liu X, Wu Y, Wang Y, Cui J, Sun J, Bai Y and Lang M: ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1. Exp Ther Med 21: 616, 2021.
APA
Wang, M., Liu, X., Wu, Y., Wang, Y., Cui, J., Sun, J. ... Lang, M. (2021). ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1. Experimental and Therapeutic Medicine, 21, 616. https://doi.org/10.3892/etm.2021.10048
MLA
Wang, M., Liu, X., Wu, Y., Wang, Y., Cui, J., Sun, J., Bai, Y., Lang, M."ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1". Experimental and Therapeutic Medicine 21.6 (2021): 616.
Chicago
Wang, M., Liu, X., Wu, Y., Wang, Y., Cui, J., Sun, J., Bai, Y., Lang, M."ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1". Experimental and Therapeutic Medicine 21, no. 6 (2021): 616. https://doi.org/10.3892/etm.2021.10048
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team