Open Access

Regulatory mechanism of calcium/calmodulin‑dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review)

  • Authors:
    • Kexin Ma
    • Guoping Ma
    • Zijing Guo
    • Gang Liu
    • Wenjie Liang
  • View Affiliations

  • Published online on: April 20, 2021     https://doi.org/10.3892/etm.2021.10088
  • Article Number: 656
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ventricular arrhythmia (VA) is a highly fatal arrhythmia that involves multiple ion channels. Of all sudden cardiac death events, ~85% result from VAs, including ventricular tachycardia and ventricular fibrillation. Calcium/calmodulin‑dependent pro‑tein kinase II (CaMKII) is an important ion channel regulator that participates in the excitation‑contraction coupling of the heart, and as such is important for regulating its electrophysiological function. CaMKII can be activated in a Ca2+/calmodulin (CaM)‑dependent or Ca2+/CaM‑independent manner, serving a key role in the occurrence and development of VA. The present review aimed to determine whether activated CaMKII induces early afterdepolarizations and delayed afterdepolarizations that result in VA by regulating sodium, potassium and calcium ions. Assessing VA mechanisms based on the CaMKII pathway is of great significance to the clinical treatment of VA and the de‑velopment of effective drugs for use in clinical practice.

Related Articles

Journal Cover

June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ma K, Ma G, Guo Z, Liu G and Liang W: Regulatory mechanism of calcium/calmodulin‑dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review). Exp Ther Med 21: 656, 2021
APA
Ma, K., Ma, G., Guo, Z., Liu, G., & Liang, W. (2021). Regulatory mechanism of calcium/calmodulin‑dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review). Experimental and Therapeutic Medicine, 21, 656. https://doi.org/10.3892/etm.2021.10088
MLA
Ma, K., Ma, G., Guo, Z., Liu, G., Liang, W."Regulatory mechanism of calcium/calmodulin‑dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review)". Experimental and Therapeutic Medicine 21.6 (2021): 656.
Chicago
Ma, K., Ma, G., Guo, Z., Liu, G., Liang, W."Regulatory mechanism of calcium/calmodulin‑dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review)". Experimental and Therapeutic Medicine 21, no. 6 (2021): 656. https://doi.org/10.3892/etm.2021.10088