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Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of Lonicera japonica using spectrum‑effect correlation

  • Authors:
    • Jing-Xin Ding
    • Chang Liu
    • Xiong-Wei Liu
    • Wei-Na Yan
    • Wen-Pei  Li
    • Hui Shi
    • Jia-Xin Li
    • Cheng-Lin Tang
    • Ying Zhou
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550025, P.R. China, School of Pharmaceutical Sciences, Guizhou University, Guiyang, Guizhou 550025, P.R. China, College of Life Sciences, Guizhou University, Guiyang, Guizhou 550025, P.R. China, Guizhou Agricultural Exhibition Hall, Guiyang, Guizhou 550001, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 665
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    Published online on: April 22, 2021
       https://doi.org/10.3892/etm.2021.10097
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Abstract

Liquid chromatography (LC) is a common and straight forward approach used in the evaluation of the quality of Traditional Chinese Medicines (TCMs). Quality control is a critical step when systematically assessing the efficacy of TCMs. In the present study, the spectrum‑effect correlation method was used to identify pharmacologically active substances. The aim of the present study was to investigate the underlying correlations between common chemical compounds with antipyretic effects and the anti‑endotoxin activity of Lonicera japonica. The common chemical constituents of Lonicera japonica were analyzed using LC, and the antipyretic effects and anti‑endotoxin activity were determined using ELISAs. Combining the results of bivariate and principal component analysis methods, eight active constituents were qualitatively and quantitatively analyzed. The results of these analyses indicated that neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and isochlorogenic acids A, B and C served a synergistic role with respect to antipyretic effects and anti‑endotoxin activity. The present study lays a foundation for the future clinical use of Lonicera japonica.
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Copy and paste a formatted citation
Spandidos Publications style
Ding J, Liu C, Liu X, Yan W, Li W, Shi H, Li J, Tang C and Zhou Y: Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation. Exp Ther Med 22: 665, 2021.
APA
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H. ... Zhou, Y. (2021). Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation. Experimental and Therapeutic Medicine, 22, 665. https://doi.org/10.3892/etm.2021.10097
MLA
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H., Li, J., Tang, C., Zhou, Y."Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation". Experimental and Therapeutic Medicine 22.1 (2021): 665.
Chicago
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H., Li, J., Tang, C., Zhou, Y."Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation". Experimental and Therapeutic Medicine 22, no. 1 (2021): 665. https://doi.org/10.3892/etm.2021.10097
Copy and paste a formatted citation
x
Spandidos Publications style
Ding J, Liu C, Liu X, Yan W, Li W, Shi H, Li J, Tang C and Zhou Y: Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation. Exp Ther Med 22: 665, 2021.
APA
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H. ... Zhou, Y. (2021). Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation. Experimental and Therapeutic Medicine, 22, 665. https://doi.org/10.3892/etm.2021.10097
MLA
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H., Li, J., Tang, C., Zhou, Y."Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation". Experimental and Therapeutic Medicine 22.1 (2021): 665.
Chicago
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H., Li, J., Tang, C., Zhou, Y."Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation". Experimental and Therapeutic Medicine 22, no. 1 (2021): 665. https://doi.org/10.3892/etm.2021.10097
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