Open Access

Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of Lonicera japonica using spectrum‑effect correlation

  • Authors:
    • Jing-Xin Ding
    • Chang Liu
    • Xiong-Wei Liu
    • Wei-Na Yan
    • Wen-Pei  Li
    • Hui Shi
    • Jia-Xin Li
    • Cheng-Lin Tang
    • Ying Zhou
  • View Affiliations

  • Published online on: April 22, 2021     https://doi.org/10.3892/etm.2021.10097
  • Article Number: 665
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Liquid chromatography (LC) is a common and straight forward approach used in the evaluation of the quality of Traditional Chinese Medicines (TCMs). Quality control is a critical step when systematically assessing the efficacy of TCMs. In the present study, the spectrum‑effect correlation method was used to identify pharmacologically active substances. The aim of the present study was to investigate the underlying correlations between common chemical compounds with antipyretic effects and the anti‑endotoxin activity of Lonicera japonica. The common chemical constituents of Lonicera japonica were analyzed using LC, and the antipyretic effects and anti‑endotoxin activity were determined using ELISAs. Combining the results of bivariate and principal component analysis methods, eight active constituents were qualitatively and quantitatively analyzed. The results of these analyses indicated that neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and isochlorogenic acids A, B and C served a synergistic role with respect to antipyretic effects and anti‑endotoxin activity. The present study lays a foundation for the future clinical use of Lonicera japonica.
View Figures
View References

Related Articles

Journal Cover

July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ding J, Liu C, Liu X, Yan W, Li W, Shi H, Li J, Tang C and Zhou Y: Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation. Exp Ther Med 22: 665, 2021
APA
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H. ... Zhou, Y. (2021). Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation. Experimental and Therapeutic Medicine, 22, 665. https://doi.org/10.3892/etm.2021.10097
MLA
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H., Li, J., Tang, C., Zhou, Y."Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation". Experimental and Therapeutic Medicine 22.1 (2021): 665.
Chicago
Ding, J., Liu, C., Liu, X., Yan, W., Li, W., Shi, H., Li, J., Tang, C., Zhou, Y."Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <em>Lonicera japonica</em> using spectrum‑effect correlation". Experimental and Therapeutic Medicine 22, no. 1 (2021): 665. https://doi.org/10.3892/etm.2021.10097