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Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia

  • Authors:
    • Ioannis Mavroudis
    • Foivos Petrides
    • Dimitrios Kazis
    • Symela Chatzikonstantinou
    • Eleni Karantali
    • Alin Ciobica
    • Alin-Constantin Iordache
    • Romeo Dobrin
    • Constantin Trus
    • Samuel Njau
    • Vasiliki Costa
    • Stavros Baloyannis
  • View Affiliations / Copyright

    Affiliations: Laboratory of Neuropathology and Electron Microscopy First Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki 54634, Greece, Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece, Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University, Iasi 700506, Romania, Faculty of Medicine, ‘Grigore T. Popa’, University of Medicine and Pharmacy, Iasi 700115, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine, Dunarea de Jos University, Galati 050094, Romania, Department of Forensic Medicine and Toxicology, Aristotle University of Thessaloniki, Thessaloniki 54634, Greece
    Copyright: © Mavroudis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 669
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    Published online on: April 22, 2021
       https://doi.org/10.3892/etm.2021.10101
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Abstract

Schizophrenia is a severe brain disorder characterized by certain types of delusion, hallucination and thought disorder. Studies have revealed impaired synaptic plasticity and reduced gamma‑aminobutyric acid levels of the visual cortex in patients with schizophrenia. While previous work established a critical role for interneurons and cortical connectivity in the generation of hallucinations, the present study set out to examine the morphology of pyramidal cells and interneurons from layers 3 and 4 in the primary visual cortex from schizophrenic brains and to identify any dendritic and spinal alterations in comparison to normal control brains. The morphological and morphometric changes of the pyramidal cells and the interneurons of the visual cortices of 10 brains obtained from patients with schizophrenia, in comparison to 10 age‑matched controls, were studied using the Golgi method and 3D neuronal reconstruction techniques. Analysis using the Golgi impregnation technique revealed a significant loss of distal dendritic segments, tortuous branches and varicosities and an overall restriction of the dendritic field in the brains of schizophrenic patients in both pyramidal cells and in aspiny interneurons. The present results may explain certain clinical phenomena associated with the visual cortex usually encountered in schizophrenia.
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Copy and paste a formatted citation
Spandidos Publications style
Mavroudis I, Petrides F, Kazis D, Chatzikonstantinou S, Karantali E, Ciobica A, Iordache A, Dobrin R, Trus C, Njau S, Njau S, et al: Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia. Exp Ther Med 22: 669, 2021.
APA
Mavroudis, I., Petrides, F., Kazis, D., Chatzikonstantinou, S., Karantali, E., Ciobica, A. ... Baloyannis, S. (2021). Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia. Experimental and Therapeutic Medicine, 22, 669. https://doi.org/10.3892/etm.2021.10101
MLA
Mavroudis, I., Petrides, F., Kazis, D., Chatzikonstantinou, S., Karantali, E., Ciobica, A., Iordache, A., Dobrin, R., Trus, C., Njau, S., Costa, V., Baloyannis, S."Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia". Experimental and Therapeutic Medicine 22.1 (2021): 669.
Chicago
Mavroudis, I., Petrides, F., Kazis, D., Chatzikonstantinou, S., Karantali, E., Ciobica, A., Iordache, A., Dobrin, R., Trus, C., Njau, S., Costa, V., Baloyannis, S."Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia". Experimental and Therapeutic Medicine 22, no. 1 (2021): 669. https://doi.org/10.3892/etm.2021.10101
Copy and paste a formatted citation
x
Spandidos Publications style
Mavroudis I, Petrides F, Kazis D, Chatzikonstantinou S, Karantali E, Ciobica A, Iordache A, Dobrin R, Trus C, Njau S, Njau S, et al: Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia. Exp Ther Med 22: 669, 2021.
APA
Mavroudis, I., Petrides, F., Kazis, D., Chatzikonstantinou, S., Karantali, E., Ciobica, A. ... Baloyannis, S. (2021). Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia. Experimental and Therapeutic Medicine, 22, 669. https://doi.org/10.3892/etm.2021.10101
MLA
Mavroudis, I., Petrides, F., Kazis, D., Chatzikonstantinou, S., Karantali, E., Ciobica, A., Iordache, A., Dobrin, R., Trus, C., Njau, S., Costa, V., Baloyannis, S."Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia". Experimental and Therapeutic Medicine 22.1 (2021): 669.
Chicago
Mavroudis, I., Petrides, F., Kazis, D., Chatzikonstantinou, S., Karantali, E., Ciobica, A., Iordache, A., Dobrin, R., Trus, C., Njau, S., Costa, V., Baloyannis, S."Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia". Experimental and Therapeutic Medicine 22, no. 1 (2021): 669. https://doi.org/10.3892/etm.2021.10101
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