Open Access

Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral ischemia

  • Authors:
    • Junjie Liu
    • Zehua Gong
    • Juan Wu
    • Shaopeng Liu
    • Xue Wang
    • Jingyao Wang
    • Jiwei Xu
    • Jianmin Li
    • Yaning Zhao
  • View Affiliations

  • Published online on: May 2, 2021     https://doi.org/10.3892/etm.2021.10127
  • Article Number: 695
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypoxic postconditioning (HPC) has been reported to be a beneficial and promising treatment for global cerebral ischemia (GCI). However, its neuroprotective mechanism remains unclear. The aim of the present study was to determine whether the protective effects of HPC in a rat model of GCI were due to the upregulation of autophagy via the silent information regulator transcript‑1 (SIRT1)/Forkhead box protein 1 (FoxO1) pathway. Morris water maze test revealed that HPC attenuated cognitive damage in GCI rats. HPC also significantly increased the levels of the autophagy‑related protein LC3‑II, SIRT1 and FoxO1 compared with those in the GCI group. However, the HPC‑induced LC3‑II upregulation was blocked by the SIRT1 inhibitor EX527. These results suggested that the beneficial effects of HPC on GCI rats were due to the upregulation of ischemiainduced autophagy and involved the SIRT1/FoxO1 signaling pathway.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu J, Gong Z, Wu J, Liu S, Wang X, Wang J, Xu J, Li J and Zhao Y: Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral ischemia. Exp Ther Med 22: 695, 2021
APA
Liu, J., Gong, Z., Wu, J., Liu, S., Wang, X., Wang, J. ... Zhao, Y. (2021). Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral ischemia. Experimental and Therapeutic Medicine, 22, 695. https://doi.org/10.3892/etm.2021.10127
MLA
Liu, J., Gong, Z., Wu, J., Liu, S., Wang, X., Wang, J., Xu, J., Li, J., Zhao, Y."Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral ischemia". Experimental and Therapeutic Medicine 22.1 (2021): 695.
Chicago
Liu, J., Gong, Z., Wu, J., Liu, S., Wang, X., Wang, J., Xu, J., Li, J., Zhao, Y."Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral ischemia". Experimental and Therapeutic Medicine 22, no. 1 (2021): 695. https://doi.org/10.3892/etm.2021.10127