Open Access

Role of microRNAs in intervertebral disc degeneration (Review)

  • Authors:
    • Fengguang Yang
    • Jizu Wang
    • Zhixin Chen
    • Yuping Yang
    • Wenhui Zhang
    • Shifang Guo
    • Qingshan Yang
  • View Affiliations

  • Published online on: June 10, 2021     https://doi.org/10.3892/etm.2021.10292
  • Article Number: 860
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unknown pathogenesis. MicroRNAs (miRNAs/miRs) participate in the development of a number of diseases, including IDD. Abnormal expression of miRNAs in the intervertebral disc is implicated in various pathological processes underlying the development of IDD, including nucleus pulposus (NP) cell (NPC) proliferation, NPC apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. The focus of the present review was the advances in research on the involvement of miRNAs in the mechanism underlying IDD. Further research is expected to identify markers for early diagnosis of IDD and new targets for delaying or reversing IDD.

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August-2021
Volume 22 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yang F, Wang J, Chen Z, Yang Y, Zhang W, Guo S and Yang Q: Role of microRNAs in intervertebral disc degeneration (Review). Exp Ther Med 22: 860, 2021
APA
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., & Yang, Q. (2021). Role of microRNAs in intervertebral disc degeneration (Review). Experimental and Therapeutic Medicine, 22, 860. https://doi.org/10.3892/etm.2021.10292
MLA
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., Yang, Q."Role of microRNAs in intervertebral disc degeneration (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 860.
Chicago
Yang, F., Wang, J., Chen, Z., Yang, Y., Zhang, W., Guo, S., Yang, Q."Role of microRNAs in intervertebral disc degeneration (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 860. https://doi.org/10.3892/etm.2021.10292