Open Access

Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)

  • Authors:
    • Mihai-Daniel Dumitrache
    • Ana Stefania Jieanu
    • Cristian Scheau
    • Ioana Anca Badarau
    • George Denis Alexandru Popescu
    • Ana Caruntu
    • Daniel Octavian Costache
    • Raluca Simona Costache
    • Carolina Constantin
    • Monica Neagu
    • Constantin Caruntu
  • View Affiliations

  • Published online on: June 29, 2021     https://doi.org/10.3892/etm.2021.10349
  • Article Number: 917
  • Copyright: © Dumitrache et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chronic obstructive pulmonary disease (COPD) and asthma are chronic respiratory diseases with high prevalence and mortality that significantly alter the quality of life in affected patients. While the cellular and molecular mechanisms engaged in the development and evolution of these two conditions are different, COPD and asthma share a wide array of symptoms and clinical signs that may impede differential diagnosis. However, the distinct signaling pathways regulating cough and airway hyperresponsiveness employ the interaction of different cells, molecules, and receptors. Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a major role in cough and airway inflammation. Consequently, its agonist, capsaicin, is of substantial interest in exploring the cellular effects and regulatory pathways that mediate these respiratory conditions. Increasingly more studies emphasize the use of capsaicin for the inhalation cough challenge, yet the involvement of TRPV1 in cough, bronchoconstriction, and the initiation of inflammation has not been entirely revealed. This review outlines a comparative perspective on the effects of capsaicin and its receptor in the pathophysiology of COPD and asthma, underlying the complex entanglement of molecular signals that bridge the alteration of cellular function with the multitude of clinical effects.
View Figures
View References

Related Articles

Journal Cover

September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Dumitrache M, Jieanu AS, Scheau C, Badarau IA, Popescu GD, Caruntu A, Costache DO, Costache RS, Constantin C, Neagu M, Neagu M, et al: Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review). Exp Ther Med 22: 917, 2021
APA
Dumitrache, M., Jieanu, A.S., Scheau, C., Badarau, I.A., Popescu, G.D., Caruntu, A. ... Caruntu, C. (2021). Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review). Experimental and Therapeutic Medicine, 22, 917. https://doi.org/10.3892/etm.2021.10349
MLA
Dumitrache, M., Jieanu, A. S., Scheau, C., Badarau, I. A., Popescu, G. D., Caruntu, A., Costache, D. O., Costache, R. S., Constantin, C., Neagu, M., Caruntu, C."Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 917.
Chicago
Dumitrache, M., Jieanu, A. S., Scheau, C., Badarau, I. A., Popescu, G. D., Caruntu, A., Costache, D. O., Costache, R. S., Constantin, C., Neagu, M., Caruntu, C."Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 917. https://doi.org/10.3892/etm.2021.10349