Open Access

Kir4.1 may represent a novel therapeutic target for diabetic retinopathy (Review)

  • Authors:
    • Xiaoyu Li
    • Jiajun Lv
    • Jiazhi Li
    • Xiang Ren
  • View Affiliations

  • Published online on: July 15, 2021     https://doi.org/10.3892/etm.2021.10453
  • Article Number: 1021
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

As the major cause of irreversible loss of vision in adults, diabetic retinopathy (DR) is one of the most serious complications of diabetes. The imbalance of the retinal microenvironment and destruction of the blood‑retinal barrier have a significant role in the progression of DR. Inward rectifying potassium channel 4.1 (Kir4.1) is located on Müller cells and is closely related to potassium homeostasis, water balance and glutamate clearance in the whole retina. The present review discusses the functions of Kir4.1 in regulating the retinal microenvironment and related biological mechanisms in DR. In the future, Kir4.1 may represent a novel alternative therapeutic target for DR through affecting the retinal microenvironment.

Related Articles

Journal Cover

September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Lv J, Li J and Ren X: Kir4.1 may represent a novel therapeutic target for diabetic retinopathy (Review). Exp Ther Med 22: 1021, 2021
APA
Li, X., Lv, J., Li, J., & Ren, X. (2021). Kir4.1 may represent a novel therapeutic target for diabetic retinopathy (Review). Experimental and Therapeutic Medicine, 22, 1021. https://doi.org/10.3892/etm.2021.10453
MLA
Li, X., Lv, J., Li, J., Ren, X."Kir4.1 may represent a novel therapeutic target for diabetic retinopathy (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 1021.
Chicago
Li, X., Lv, J., Li, J., Ren, X."Kir4.1 may represent a novel therapeutic target for diabetic retinopathy (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1021. https://doi.org/10.3892/etm.2021.10453