Kir4.1 may represent a novel therapeutic target for diabetic retinopathy (Review)
- Xiaoyu Li
- Jiajun Lv
- Jiazhi Li
- Xiang Ren
Affiliations: Department of Histology and Embryology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Radiotherapy Oncology, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China
- Published online on: July 15, 2021 https://doi.org/10.3892/etm.2021.10453
Copyright: © Li
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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As the major cause of irreversible loss of vision in adults, diabetic retinopathy (DR) is one of the most serious complications of diabetes. The imbalance of the retinal microenvironment and destruction of the blood‑retinal barrier have a significant role in the progression of DR. Inward rectifying potassium channel 4.1 (Kir4.1) is located on Müller cells and is closely related to potassium homeostasis, water balance and glutamate clearance in the whole retina. The present review discusses the functions of Kir4.1 in regulating the retinal microenvironment and related biological mechanisms in DR. In the future, Kir4.1 may represent a novel alternative therapeutic target for DR through affecting the retinal microenvironment.