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MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α

  • Authors:
    • Nengjing Gong
    • Xiaohuai Yang
    • Xiaoyu Li
    • Yuyu Jiang
    • Cuifang Gu
    • Shasha Ma
    • Qin Gao
    • Xiangyang Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital of Bengbu Medical College, Anhui 233000, P.R. China, Department of Urology, The First Affiliated Hospital of Bengbu Medical College, Anhui 233000, P.R. China, Department of Anesthesiology, The First Affiliated Hospital of Bengbu Medical College, Anhui 233000, P.R. China, Department of Anesthesiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, P.R. China, Department of Physiology, Key Laboratory of Basic and Clinical Cardiovascular Diseases, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1077
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    Published online on: July 28, 2021
       https://doi.org/10.3892/etm.2021.10511
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Abstract

Autophagy and apoptosis are key factors in myocardial ischemia/reperfusion (I/R) injury. MicroRNAs (miRNAs or miRs) participate in occurrence and development of myocardial I/R injury by regulating autophagy and apoptosis. The purpose of the present study was to investigate the role of miR‑590‑3p in the regulation of autophagy and apoptosis in hypoxia/reoxygenation (H/R)‑treated cardiomyocytes. Following 6 h hypoxia and 6 h reoxygenation in primary rat cardiomyocytes, miR‑590‑3p was downregulated. Transfection of miR‑590‑3p mimic inhibited the increased autophagy and apoptosis following H/R treatment. Subsequent experiments demonstrated that miR‑590‑3p regulated induction of autophagy and apoptosis by targeting hypoxia inducible factor (HIF)‑1α. Forced expression of HIF‑1α rescued the protective effect of miR‑590‑3p on H/R‑induced cardiomyocytes. In summary, the present study showed that miR‑590‑3p exhibited a protective effect on H/R‑induced cardiomyocyte injury and may be a novel target for the treatment of myocardial ischemia disease.
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Copy and paste a formatted citation
Spandidos Publications style
Gong N, Yang X, Li X, Jiang Y, Gu C, Ma S, Gao Q and Cheng X: MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α. Exp Ther Med 22: 1077, 2021.
APA
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S. ... Cheng, X. (2021). MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α. Experimental and Therapeutic Medicine, 22, 1077. https://doi.org/10.3892/etm.2021.10511
MLA
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S., Gao, Q., Cheng, X."MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α". Experimental and Therapeutic Medicine 22.4 (2021): 1077.
Chicago
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S., Gao, Q., Cheng, X."MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1077. https://doi.org/10.3892/etm.2021.10511
Copy and paste a formatted citation
x
Spandidos Publications style
Gong N, Yang X, Li X, Jiang Y, Gu C, Ma S, Gao Q and Cheng X: MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α. Exp Ther Med 22: 1077, 2021.
APA
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S. ... Cheng, X. (2021). MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α. Experimental and Therapeutic Medicine, 22, 1077. https://doi.org/10.3892/etm.2021.10511
MLA
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S., Gao, Q., Cheng, X."MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α". Experimental and Therapeutic Medicine 22.4 (2021): 1077.
Chicago
Gong, N., Yang, X., Li, X., Jiang, Y., Gu, C., Ma, S., Gao, Q., Cheng, X."MicroRNA‑590‑3p relieves hypoxia/reoxygenation induced cardiomyocytes apoptosis and autophagy by targeting HIF‑1α". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1077. https://doi.org/10.3892/etm.2021.10511
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