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Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling

  • Authors:
    • Wenwen Wang
    • Zijing Deng
    • Guiping Liu
    • Jie Yang
    • Wei Zhou
    • Chen Zhang
    • Weigan Shen
    • Yu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China, Department of Rheumatology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Internal Medicine, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1120
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    Published online on: August 4, 2021
       https://doi.org/10.3892/etm.2021.10554
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Abstract

Platelet‑derived extracellular vesicles (PEVs), which are generated from the plasma membrane during platelet activation, may be involved in the inflammatory processes of rheumatoid arthritis (RA). The motility of RA fibroblast‑like synoviocytes (RA‑FLS) plays a key role in the development of synovial inflammation and joint erosion. However, the effects of PEVs on the motility of RA‑FLS remain unclear. Thus, the present study aimed to investigate the active contents and potential molecular mechanisms underlying the role of PEVs in regulating the migration and invasion of RA‑FLS. The results demonstrated that PEVs contain certain chemokines associated with cell migration and invasion, including C‑C motif chemokine ligand 5, C‑X‑C motif chemokine ligand (CXCL)4 and CXCL7. Furthermore, SB225002, an antagonist of C‑X‑C motif chemokine receptor 2 (CXCR2; a CXCL7 receptor), partially prevented the migration and invasion of RA‑FLS induced by PEVs, suggesting that PEVs may activate a CXCR2‑mediated signaling pathway in RA‑FLS. In addition, SB225002 antagonized the phosphorylation of IκB and NF‑κB in RA‑FLS induced by PEVs. Taken together, the results of the present study suggested that PEVs may promote the migration and invasion of RA‑FLS by activating the NF‑κB pathway mediated by the CXCR2 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Deng Z, Liu G, Yang J, Zhou W, Zhang C, Shen W and Zhang Y: Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling. Exp Ther Med 22: 1120, 2021.
APA
Wang, W., Deng, Z., Liu, G., Yang, J., Zhou, W., Zhang, C. ... Zhang, Y. (2021). Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling. Experimental and Therapeutic Medicine, 22, 1120. https://doi.org/10.3892/etm.2021.10554
MLA
Wang, W., Deng, Z., Liu, G., Yang, J., Zhou, W., Zhang, C., Shen, W., Zhang, Y."Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling". Experimental and Therapeutic Medicine 22.4 (2021): 1120.
Chicago
Wang, W., Deng, Z., Liu, G., Yang, J., Zhou, W., Zhang, C., Shen, W., Zhang, Y."Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1120. https://doi.org/10.3892/etm.2021.10554
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Deng Z, Liu G, Yang J, Zhou W, Zhang C, Shen W and Zhang Y: Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling. Exp Ther Med 22: 1120, 2021.
APA
Wang, W., Deng, Z., Liu, G., Yang, J., Zhou, W., Zhang, C. ... Zhang, Y. (2021). Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling. Experimental and Therapeutic Medicine, 22, 1120. https://doi.org/10.3892/etm.2021.10554
MLA
Wang, W., Deng, Z., Liu, G., Yang, J., Zhou, W., Zhang, C., Shen, W., Zhang, Y."Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling". Experimental and Therapeutic Medicine 22.4 (2021): 1120.
Chicago
Wang, W., Deng, Z., Liu, G., Yang, J., Zhou, W., Zhang, C., Shen, W., Zhang, Y."Platelet‑derived extracellular vesicles promote the migration and invasion of rheumatoid arthritis fibroblast‑like synoviocytes via CXCR2 signaling". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1120. https://doi.org/10.3892/etm.2021.10554
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