Open Access

Preparation of docetaxel‑loaded, glycyrrhetinic acid‑modified nanoparticles and their liver‑targeting and antitumor activity

  • Authors:
    • Hantao Xue
    • Liya Qin
    • Longxiang Zhang
    • Xiaocheng Li
    • Fei Wu
    • Weiyu Wang
    • Chen Wang
    • Wenbin Diao
    • Bin Jiang
    • Bo Lian
    • Jingliang Wu
    • Jingkun Bai
    • Tongyi Sun
    • Chunling Zhao
    • Meihua Qu
    • Wenjing Yu
    • Yubing Wang
    • Zhiqin Gao
  • View Affiliations

  • Published online on: August 9, 2021     https://doi.org/10.3892/etm.2021.10578
  • Article Number: 1144
  • Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Liver cancer is one of the most common malignancies worldwide and poses a serious threat to human health. The most important treatment method, liver cancer chemotherapy, is limited due to its high toxicity and poor specificity. Targeted drug delivery systems have emerged as novel therapeutic strategies that deliver precise, substantial drug doses to target sites via targeting vectors and enhance the therapeutic efficacy. In the present study, glycyrrhetinic acid‑modified hyaluronic acid (GA‑HA) was used as a carrier for the model drug docetaxel (DTX) to prepare DTX‑loaded GA‑HA nanoparticles (DTX/GA‑HA‑NPs). The results indicated that the DTX/GA‑HA‑NPs exhibited high monodispersity (particle dispersity index, 0.209±0.116) and desirable particle size (208.73±5.0 nm) and zeta potential (‑27.83±3.14 mV). The drug loading capacity and encapsulation efficiency of the NPs were 12.59±0.68 and 85.38±4.62%, respectively. Furthermore, it was determined that FITC‑GA‑HA was taken up by cells and distributed in the cytoplasm. DTX and DTX/GA‑HA (just the DTX delivered by the nanoparticle) aggregated and altered the structure of cellular microtubules. Compared with DTX alone, DTX/GA‑HA‑NPs had a stronger inhibitory effect on HepG2 cell proliferation and promoted apoptosis of HepG2 cells. All experimental results indicated that DTX/GA‑HA‑NPs were successfully prepared and had liver‑targeting and antitumor activities in vitro, which provided a foundation for future in vivo studies of the antitumor effects of DTX/GA‑HA‑NPs.
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October-2021
Volume 22 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Xue H, Qin L, Zhang L, Li X, Wu F, Wang W, Wang C, Diao W, Jiang B, Lian B, Lian B, et al: Preparation of docetaxel‑loaded, glycyrrhetinic acid‑modified nanoparticles and their liver‑targeting and antitumor activity. Exp Ther Med 22: 1144, 2021
APA
Xue, H., Qin, L., Zhang, L., Li, X., Wu, F., Wang, W. ... Gao, Z. (2021). Preparation of docetaxel‑loaded, glycyrrhetinic acid‑modified nanoparticles and their liver‑targeting and antitumor activity. Experimental and Therapeutic Medicine, 22, 1144. https://doi.org/10.3892/etm.2021.10578
MLA
Xue, H., Qin, L., Zhang, L., Li, X., Wu, F., Wang, W., Wang, C., Diao, W., Jiang, B., Lian, B., Wu, J., Bai, J., Sun, T., Zhao, C., Qu, M., Yu, W., Wang, Y., Gao, Z."Preparation of docetaxel‑loaded, glycyrrhetinic acid‑modified nanoparticles and their liver‑targeting and antitumor activity". Experimental and Therapeutic Medicine 22.4 (2021): 1144.
Chicago
Xue, H., Qin, L., Zhang, L., Li, X., Wu, F., Wang, W., Wang, C., Diao, W., Jiang, B., Lian, B., Wu, J., Bai, J., Sun, T., Zhao, C., Qu, M., Yu, W., Wang, Y., Gao, Z."Preparation of docetaxel‑loaded, glycyrrhetinic acid‑modified nanoparticles and their liver‑targeting and antitumor activity". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1144. https://doi.org/10.3892/etm.2021.10578