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Role of Helicobacter pylori in the triggering and evolution of hemorrhagic gastro‑duodenal lesions

  • Authors:
    • Dragos George Popa
    • Cosmin Vasile Obleagă
    • Bogdan Socea
    • Dragos Serban
    • Marius Eugen Ciurea
    • Marian Diaconescu
    • Ionică Daniel Vîlcea
    • Cristian Meșină
    • Cecil Mirea
    • Dan Nicolae Florescu
    • Vlad Dumitru Baleanu
    • Meda Comandasu
    • Mihai Silviu Tudosie
    • Laura Carina Tribus
    • Bogdan Niculescu
  • View Affiliations / Copyright

    Affiliations: Department of Plastic and Reconstructive Surgery, Craiova University of Medicine and Pharmacy, 200349 Craiova, Romania, Department of Surgery, Craiova University of Medicine and Pharmacy, 200349 Craiova, Romania, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania, Department of Gastroenterology, Craiova University of Medicine and Pharmacy, 200349 Craiova, Romania, Fourth Department of General Surgery, Emergency University Hospital Bucharest, 050098 Bucharest, Romania, Department of Sports and Health, ‘Constantin Brancusi’ University, 210152 Targu Jiu, Romania
    Copyright: © Popa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1147
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    Published online on: August 9, 2021
       https://doi.org/10.3892/etm.2021.10582
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Abstract

The majority of studies concerning Helicobacter pylori (H. pylori) are oriented towards the implication of infection with H. pylori in processes that end in the formation of neoplasia, without assessing the impact of the bacterium in triggering acute gastroduodenal hemorrhagic episodes. The present study includes 166 patients with upper digestive hemorrhage, admitted to the ATI Clinic, the Gastroenterology Clinic or to the Surgery II Clinic of the County Emergency Clinical Hospital in Craiova, Romania between 2017 and 2019. All patients were monitored for evolution and received treatment according to current guidelines, and hemorrhagic lesions were biopsied. In the study group, 56.8% of the patients with upper gastrointestinal bleeding (UGIB) were positive for H. pylori and 43.2% were negative. In patients less than 50 years of age, non‑steroidal anti‑inflammatory drug (NSAID) use and H. pylori infection had a cumulative effect in causing bleeding lesions, but in patients older than 50 years of age, the use of NSAIDs was replaced by therapies with oral antiplatelet or anticoagulant agents. The need for hemostasis surgery was more common in patients who exhibited H. pylori‑positive UGIB compared to H. pylori‑negative (16 vs. 9.7%). In patients with H. pylori‑positive hemorrhagic lesions, gastric resection was frequently required to obtain hemostasis. Persistence of H. pylori infection in patients with a history of gastric resection (4.1%) still predisposes to a hemorrhagic or neoplastic complication.
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Copy and paste a formatted citation
Spandidos Publications style
Popa DG, Obleagă CV, Socea B, Serban D, Ciurea ME, Diaconescu M, Vîlcea ID, Meșină C, Mirea C, Florescu D, Florescu D, et al: Role of <em>Helicobacter pylori</em> in the triggering and evolution of hemorrhagic gastro‑duodenal lesions. Exp Ther Med 22: 1147, 2021.
APA
Popa, D.G., Obleagă, C.V., Socea, B., Serban, D., Ciurea, M.E., Diaconescu, M. ... Niculescu, B. (2021). Role of <em>Helicobacter pylori</em> in the triggering and evolution of hemorrhagic gastro‑duodenal lesions. Experimental and Therapeutic Medicine, 22, 1147. https://doi.org/10.3892/etm.2021.10582
MLA
Popa, D. G., Obleagă, C. V., Socea, B., Serban, D., Ciurea, M. E., Diaconescu, M., Vîlcea, I. D., Meșină, C., Mirea, C., Florescu, D., Baleanu, V. D., Comandasu, M., Tudosie, M. S., Tribus, L. C., Niculescu, B."Role of <em>Helicobacter pylori</em> in the triggering and evolution of hemorrhagic gastro‑duodenal lesions". Experimental and Therapeutic Medicine 22.4 (2021): 1147.
Chicago
Popa, D. G., Obleagă, C. V., Socea, B., Serban, D., Ciurea, M. E., Diaconescu, M., Vîlcea, I. D., Meșină, C., Mirea, C., Florescu, D., Baleanu, V. D., Comandasu, M., Tudosie, M. S., Tribus, L. C., Niculescu, B."Role of <em>Helicobacter pylori</em> in the triggering and evolution of hemorrhagic gastro‑duodenal lesions". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1147. https://doi.org/10.3892/etm.2021.10582
Copy and paste a formatted citation
x
Spandidos Publications style
Popa DG, Obleagă CV, Socea B, Serban D, Ciurea ME, Diaconescu M, Vîlcea ID, Meșină C, Mirea C, Florescu D, Florescu D, et al: Role of <em>Helicobacter pylori</em> in the triggering and evolution of hemorrhagic gastro‑duodenal lesions. Exp Ther Med 22: 1147, 2021.
APA
Popa, D.G., Obleagă, C.V., Socea, B., Serban, D., Ciurea, M.E., Diaconescu, M. ... Niculescu, B. (2021). Role of <em>Helicobacter pylori</em> in the triggering and evolution of hemorrhagic gastro‑duodenal lesions. Experimental and Therapeutic Medicine, 22, 1147. https://doi.org/10.3892/etm.2021.10582
MLA
Popa, D. G., Obleagă, C. V., Socea, B., Serban, D., Ciurea, M. E., Diaconescu, M., Vîlcea, I. D., Meșină, C., Mirea, C., Florescu, D., Baleanu, V. D., Comandasu, M., Tudosie, M. S., Tribus, L. C., Niculescu, B."Role of <em>Helicobacter pylori</em> in the triggering and evolution of hemorrhagic gastro‑duodenal lesions". Experimental and Therapeutic Medicine 22.4 (2021): 1147.
Chicago
Popa, D. G., Obleagă, C. V., Socea, B., Serban, D., Ciurea, M. E., Diaconescu, M., Vîlcea, I. D., Meșină, C., Mirea, C., Florescu, D., Baleanu, V. D., Comandasu, M., Tudosie, M. S., Tribus, L. C., Niculescu, B."Role of <em>Helicobacter pylori</em> in the triggering and evolution of hemorrhagic gastro‑duodenal lesions". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1147. https://doi.org/10.3892/etm.2021.10582
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