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Article

A novel therapy for granulomatous lobular mastitis: Local heat therapy

  • Authors:
    • Xinxin Chen
    • Wangjian Zhang
    • Qiuer Yuan
    • Xiaowu Hu
    • Ting Xia
    • Tengfei Cao
    • Haixia Jia
    • Lehong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China, Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY 12144, USA
  • Article Number: 1156
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    Published online on: August 10, 2021
       https://doi.org/10.3892/etm.2021.10590
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Abstract

Granulomatous lobular mastitis (GLM) is a chronic inflammatory breast condition that is characterized by granulomatous inflammation. GLM remains a refractory disease due to its failure to respond to routine anti‑inflammatory therapies and its high recurrence rate. Thus, the present study aimed to investigate the application of local heat therapy in GLM as a potential therapeutic strategy. The results revealed that the application of local heat therapy was associated with a shortened remission time for GLM, while the remission and recurrence rates were similar to those of existing therapies. The median first remission time following local heat therapy was significantly decreased compared with that following corticosteroid therapy (5.30 months vs. 11.27 months; P<0.05). The remission rates were not significantly different between the local heat therapy (76.9%), extensive excision (90.4%) and the corticosteroid therapy (85.7%) groups (P>0.05). In addition, the recurrence rates were not statistically different between the groups (local heat therapy, 8.3%; extensive excision, 10%; and corticosteroid therapy, 10%; P>0.05). The local heat therapy showed mild adverse effects and shortened healing times compared to the other therapies; however, further confirmation is required.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Zhang W, Yuan Q, Hu X, Xia T, Cao T, Jia H and Zhang L: A novel therapy for granulomatous lobular mastitis: Local heat therapy. Exp Ther Med 22: 1156, 2021.
APA
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T. ... Zhang, L. (2021). A novel therapy for granulomatous lobular mastitis: Local heat therapy. Experimental and Therapeutic Medicine, 22, 1156. https://doi.org/10.3892/etm.2021.10590
MLA
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T., Jia, H., Zhang, L."A novel therapy for granulomatous lobular mastitis: Local heat therapy". Experimental and Therapeutic Medicine 22.4 (2021): 1156.
Chicago
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T., Jia, H., Zhang, L."A novel therapy for granulomatous lobular mastitis: Local heat therapy". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1156. https://doi.org/10.3892/etm.2021.10590
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Zhang W, Yuan Q, Hu X, Xia T, Cao T, Jia H and Zhang L: A novel therapy for granulomatous lobular mastitis: Local heat therapy. Exp Ther Med 22: 1156, 2021.
APA
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T. ... Zhang, L. (2021). A novel therapy for granulomatous lobular mastitis: Local heat therapy. Experimental and Therapeutic Medicine, 22, 1156. https://doi.org/10.3892/etm.2021.10590
MLA
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T., Jia, H., Zhang, L."A novel therapy for granulomatous lobular mastitis: Local heat therapy". Experimental and Therapeutic Medicine 22.4 (2021): 1156.
Chicago
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T., Jia, H., Zhang, L."A novel therapy for granulomatous lobular mastitis: Local heat therapy". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1156. https://doi.org/10.3892/etm.2021.10590
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