A novel therapy for granulomatous lobular mastitis: Local heat therapy

  • Authors:
    • Xinxin Chen
    • Wangjian Zhang
    • Qiuer Yuan
    • Xiaowu Hu
    • Ting Xia
    • Tengfei Cao
    • Haixia Jia
    • Lehong Zhang
  • View Affiliations

  • Published online on: August 10, 2021     https://doi.org/10.3892/etm.2021.10590
  • Article Number: 1156
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Abstract

Granulomatous lobular mastitis (GLM) is a chronic inflammatory breast condition that is characterized by granulomatous inflammation. GLM remains a refractory disease due to its failure to respond to routine anti‑inflammatory therapies and its high recurrence rate. Thus, the present study aimed to investigate the application of local heat therapy in GLM as a potential therapeutic strategy. The results revealed that the application of local heat therapy was associated with a shortened remission time for GLM, while the remission and recurrence rates were similar to those of existing therapies. The median first remission time following local heat therapy was significantly decreased compared with that following corticosteroid therapy (5.30 months vs. 11.27 months; P<0.05). The remission rates were not significantly different between the local heat therapy (76.9%), extensive excision (90.4%) and the corticosteroid therapy (85.7%) groups (P>0.05). In addition, the recurrence rates were not statistically different between the groups (local heat therapy, 8.3%; extensive excision, 10%; and corticosteroid therapy, 10%; P>0.05). The local heat therapy showed mild adverse effects and shortened healing times compared to the other therapies; however, further confirmation is required.
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October-2021
Volume 22 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen X, Zhang W, Yuan Q, Hu X, Xia T, Cao T, Jia H and Zhang L: A novel therapy for granulomatous lobular mastitis: Local heat therapy. Exp Ther Med 22: 1156, 2021
APA
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T. ... Zhang, L. (2021). A novel therapy for granulomatous lobular mastitis: Local heat therapy. Experimental and Therapeutic Medicine, 22, 1156. https://doi.org/10.3892/etm.2021.10590
MLA
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T., Jia, H., Zhang, L."A novel therapy for granulomatous lobular mastitis: Local heat therapy". Experimental and Therapeutic Medicine 22.4 (2021): 1156.
Chicago
Chen, X., Zhang, W., Yuan, Q., Hu, X., Xia, T., Cao, T., Jia, H., Zhang, L."A novel therapy for granulomatous lobular mastitis: Local heat therapy". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1156. https://doi.org/10.3892/etm.2021.10590