Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2021 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2021 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature

  • Authors:
    • Cornel Adrian Petreanu
    • Elena-Daniela Șerban
    • Maria-Magdalena Constantin
    • Cornel Savu
    • Alexandru Victor Zariosu
    • Oana Claudia Deleanu
    • Stefana Bucur
    • Traian Constantin
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, 2nd Department of Dermatology, ‘Colentina’ Clinical Hospital, 020125 Bucharest, Romania, 1st Department of Thoracic Surgery, ‘Prof. Dr. Marius Nasta’ Institute of Pneumophtisiology, 050159 Bucharest, Romania, Department of Pneumophtisiology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
  • Article Number: 1158
    |
    Published online on: August 10, 2021
       https://doi.org/10.3892/etm.2021.10592
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cutaneous basosquamous carcinoma is a variant of basal cell carcinoma that is characterized by histopathological features of both basal and squamous cell carcinoma. Due to its local invasiveness, high frequency of recurrence, and its metastatic potential, it is considered to be one of the most aggressive subtypes of basal cell carcinoma. We present the case of an 81‑year‑old male who was admitted to the hospital with incessant hemorrhage arising from a cutaneous tumor that later proved to be a basosquamous carcinoma. Due to the COVID‑19 pandemic at the time, the patient did not seek medical attention as soon as the bleeding was observed, although he did present when the symptom increased in intensity and became incessant. To our knowledge, this is the first case report of a cutaneous basosquamous carcinoma that presents with a massive life‑threatening hemorrhage tumor, thus endangering the patient's life. The clinical and histopathological features, the behavior and the treatment of cutaneous basosquamous carcinoma are further reviewed in this article.
View Figures

Figure 1

Figure 2

View References

1 

Elder DE, Massi D, Scolyer RA and Willemze R: Basal cell carcinoma. In: WHO Classification of Skin Tumors. 4th edition. International Agency for Research on Cancer, Lyon, France, pp26-34, 2018.

2 

Bichakjian CK, Olencki T, Aasi SZ, Alam M, Andersen JS, Berg D, Bowen GM, Cheney RT, Daniels GA, Glass LF, et al: Basal cell skin cancer, version 1.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 14:574–597. 2016.PubMed/NCBI View Article : Google Scholar

3 

Ciążyńska M, Sławińska M, Kamińska-Winciorek G, Lange D, Lewandowski B, Reich A, Pabianek M, Szczepaniak K, Hankiewicz A, Ułańska M, et al: Clinical and epidemiological analysis of basosquamous carcinoma: Results of the multicenter study. Sci Rep. 10(18475)2020.PubMed/NCBI View Article : Google Scholar

4 

Akay BN, Saral S, Heper AO, Erdem C and Rosendahl C: Basosquamous carcinoma: Dermoscopic clues to diagnosis. J Dermatol. 44:127–134. 2017.PubMed/NCBI View Article : Google Scholar

5 

Giacomel J, Lallas A, Argenziano G, Reggiani C, Piana S, Apalla Z, Ferrara G, Moscarella E, Longo C and Zalaudek I: Dermoscopy of basosquamous carcinoma. Br J Dermatol. 169:358–364. 2013.PubMed/NCBI View Article : Google Scholar

6 

Alam M, Desai S, Nodzenski M, Dubina M, Kim N, Martini M, Fife D, Reid D, Pirigyi M, Poon E, et al: Active ascertainment of recurrence rate after treatment of primary basal cell carcinoma (BCC). J Am Acad Dermatol. 73:323–325. 2015.PubMed/NCBI View Article : Google Scholar

7 

Tan CZ, Rieger KE and Sarin KY: Basosquamous carcinoma: Controversy, advances, and future directions. Dermatol Surg. 43:23–31. 2017.PubMed/NCBI View Article : Google Scholar

8 

Wermker K, Roknic N, Goessling K, Klein M, Schulze HJ and Hallermann C: Basosquamous carcinoma of the head and neck: Clinical and histologic characteristics and their impact on disease progression. Neoplasia. 17:301–305. 2015.PubMed/NCBI View Article : Google Scholar

9 

Zhu GA, Danial C, Liu A, Li S and Chang AL: Overall and progression-free survival in metastatic basosquamous cancer: A case series. J Am Acad Dermatol. 70:1145–1146. 2014.PubMed/NCBI View Article : Google Scholar

10 

Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, et al: Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines. Eur J Cancer. 118:10–34. 2019.PubMed/NCBI View Article : Google Scholar

11 

Ad Hoc Task Force. Connolly SM, Baker DR, Coldiron BM, Fazio MJ, Storrs PA, Vidimos AT, Zalla MJ, Brewer JD, Begolka WS, et al: AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for mohs micrographic surgery: A report of the American academy of dermatology, American college of mohs surgery, American society for dermatologic surgery association, and the American society for mohs surgery. J Am Acad Dermatol. 67:531–550. 2012.PubMed/NCBI View Article : Google Scholar

12 

Wetzig T, Woitek M, Eichhorn K, Simon JC and Paasch U: Surgical excision of basal cell carcinoma with complete margin control: Outcome at 5-year follow-up. Dermatology. 220:363–369. 2010.PubMed/NCBI View Article : Google Scholar

13 

Likhacheva A, Awan M, Barker CA, Bhatnagar A, Bradfield L, Brady MS, Buzurovic I, Geiger JL, Parvathaneni U, Zaky S and Devlin PM: Definitive and postoperative radiation therapy for basal and squamous cell cancers of the skin: Executive summary of an American society for radiation oncology clinical practice guideline. Pract Radiat Oncol. 10:8–20. 2020.PubMed/NCBI View Article : Google Scholar

14 

Keohane SG, Proby CM, Newlands C, Motley RJ, Nasr I and Mohd Mustapa MF: British Association of Dermatologists (Squamous and Basal Cell Carcinoma Guideline Development Groups). Slater DN: Royal College of Pathologists (Skin Cancer Lead). The new 8th edition of TNM staging and its implications for skin cancer: a review by the British Association of Dermatologists and the Royal College of Pathologists, U.K. Br J Dermatol. 179:824–828. 2018.PubMed/NCBI View Article : Google Scholar

15 

Lomas A, Leonardi-Bee J and Bath-Hextall F: A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol. 166:1069–1080. 2012.PubMed/NCBI View Article : Google Scholar

16 

Verkouteren JAC, Ramdas KHR, Wakkee M and Nijsten T: Epidemiology of basal cell carcinoma: Scholarly review. Br J Dermatol. 177:359–372. 2017.PubMed/NCBI View Article : Google Scholar

17 

Solovastru LG, Vata D, Statescu L, Constantin MM and Andrese E: Skin cancer between myth and reality, yet ethically constrained. Rev Rom Bioet. 12:47–52. 2014.

18 

Scrivener Y, Grosshans E and Cribier B: Variations of basal cell carcinomas according to gender, age, location and histopathological subtype. Br J Dermatol. 147:41–47. 2002.PubMed/NCBI View Article : Google Scholar

19 

Martin RC II, Edwards MJ, Cawte TG, Sewell CL and McMasters KM: Basosquamous carcinoma: Analysis of prognostic factors influencing recurrence. Cancer. 88:1365–1369. 2000.PubMed/NCBI View Article : Google Scholar

20 

Garcia C, Poletti E and Crowson AN: Basosquamous carcinoma. J Am Acad Dermatol. 60:137–143. 2009.PubMed/NCBI View Article : Google Scholar

21 

Bowman PH, Ratz JL, Knoepp TG, Barnes CJ and Finley EM: Basosquamous carcinoma. Dermatol Surg. 29:830–832. 2003.PubMed/NCBI View Article : Google Scholar

22 

Leibovitch I, Huilgol SC, Selva D, Richards S and Paver R: Basosquamous carcinoma: Treatment with mohs micrographic surgery. Cancer. 104:170–175. 2005.PubMed/NCBI View Article : Google Scholar

23 

Gallagher RP, Hill GB, Bajdik CD, Fincham S, Coldman AJ, McLean DI and Threlfall WJ: Sunlight exposure, pigmentary factors, and risk of nonmelanocytic skin cancer. I. Basal cell carcinoma. Arch Dermatol. 131:157–163. 1995.PubMed/NCBI

24 

Oldbury JW, Wain RAJ, Abas S, Dobson CM and Iyer SS: Basosquamous carcinoma: A single centre clinicopathological evaluation and proposal of an evidence-based protocol. J Skin Cancer. 3(6061395)2018.PubMed/NCBI View Article : Google Scholar

25 

Gulleth Y, Goldberg N, Silverman RP and Gastman BR: What is the best surgical margin for a basal cell carcinoma: A meta-analysis of the literature. Plast Reconstr Surg. 126:1222–1231. 2010.PubMed/NCBI View Article : Google Scholar

26 

Smeets NW, Krekels GA, Ostertag JU, Essers BA, Dirksen CD, Nieman FH and Neumann HA: Surgical excision vs Mohs' micrographic surgery for basal-cell carcinoma of the face: Randomised controlled trial. Lancet. 364:1766–1772. 2004.PubMed/NCBI View Article : Google Scholar

27 

Bath-Hextall F, Ozolins M, Armstrong SJ, Colver GB, Perkins W, Miller PS and Williams HC: Surgery versus Imiquimod for Nodular Superficial basal cell carcinoma (SINS) study group. Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): A multicentre, non-inferiority, randomised controlled trial. Lancet Oncol. 15:96–105. 2014.PubMed/NCBI View Article : Google Scholar

28 

Love WE, Bernhard JD and Bordeaux JS: Topical imiquimod or fluorouracil therapy for basal and squamous cell carcinoma: A systematic review. Arch Dermatol. 145:1431–1438. 2009.PubMed/NCBI View Article : Google Scholar

29 

Voiculescu VM, Lisievici CV, Lupu M, Vajaitu C, Draghici CC, Popa AV, Solomon I, Sebe TI, Constantin MM and Caruntu C: Mediators of inflammation in topical therapy of skin cancers. Mediators Inflamm. 10(8369690)2019.PubMed/NCBI View Article : Google Scholar

30 

Roozeboom MH, Arits AH, Nelemans PJ and Kelleners-Smeets NW: Overall treatment success after treatment of primary superficial basal cell carcinoma: A systematic review and meta-analysis of randomized and nonrandomized trials. Br J Dermatol. 167:733–756. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Petreanu CA, Șerban E, Constantin M, Savu C, Zariosu AV, Deleanu OC, Bucur S and Constantin T: Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature. Exp Ther Med 22: 1158, 2021.
APA
Petreanu, C.A., Șerban, E., Constantin, M., Savu, C., Zariosu, A.V., Deleanu, O.C. ... Constantin, T. (2021). Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature. Experimental and Therapeutic Medicine, 22, 1158. https://doi.org/10.3892/etm.2021.10592
MLA
Petreanu, C. A., Șerban, E., Constantin, M., Savu, C., Zariosu, A. V., Deleanu, O. C., Bucur, S., Constantin, T."Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature". Experimental and Therapeutic Medicine 22.4 (2021): 1158.
Chicago
Petreanu, C. A., Șerban, E., Constantin, M., Savu, C., Zariosu, A. V., Deleanu, O. C., Bucur, S., Constantin, T."Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1158. https://doi.org/10.3892/etm.2021.10592
Copy and paste a formatted citation
x
Spandidos Publications style
Petreanu CA, Șerban E, Constantin M, Savu C, Zariosu AV, Deleanu OC, Bucur S and Constantin T: Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature. Exp Ther Med 22: 1158, 2021.
APA
Petreanu, C.A., Șerban, E., Constantin, M., Savu, C., Zariosu, A.V., Deleanu, O.C. ... Constantin, T. (2021). Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature. Experimental and Therapeutic Medicine, 22, 1158. https://doi.org/10.3892/etm.2021.10592
MLA
Petreanu, C. A., Șerban, E., Constantin, M., Savu, C., Zariosu, A. V., Deleanu, O. C., Bucur, S., Constantin, T."Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature". Experimental and Therapeutic Medicine 22.4 (2021): 1158.
Chicago
Petreanu, C. A., Șerban, E., Constantin, M., Savu, C., Zariosu, A. V., Deleanu, O. C., Bucur, S., Constantin, T."Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1158. https://doi.org/10.3892/etm.2021.10592
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team