Open Access

Clinical efficiency of combination therapy using testosterone replacement therapy, phosphodiesterase 5 inhibitors and Kampo herbal medicine for eugonadal patients with late‑onset hypogonadism syndrome

  • Authors:
    • Hisashi Takeuchi
    • Hidenori Okubo
  • View Affiliations

  • Published online on: August 13, 2021     https://doi.org/10.3892/etm.2021.10608
  • Article Number: 1173
  • Copyright: © Takeuchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, the initial treatment efficiency of combination therapy using testosterone replacement therapy (TRT), herbal medicine and phosphodiesterase 5 inhibitors (PDE5i) in male patients with late‑onset hypogonadism (LOH) were assessed. A total of 21 patients were enrolled and after 12 weeks, the clinical efficacy was evaluated based on improvement of LOH symptoms via laboratory parameters and several questionnaires, including the Ageing Males' Symptoms (AMS) scale. The overall AMS scores, as well as the psychological, physical and sexual AMS factors prior to and after treatment in the TRT, testosterone enanthate (T enanthate) monotherapy and T enanthate + PDE5i treatment groups were significantly improved. In the herbal medicine group, only the AMS physiological factors were significantly improved after treatment compared with the baseline. The improvement of the overall AMS scores, as well as the physiological and sexual AMS factors, were significantly negatively correlated with the free testosterone (FT) value prior to treatment. In conclusion, treatment with combination therapy using TRT, herbal medicine and PDE5i improved AMS scores in patients with LOH syndrome. Particularly in patients with LOH syndrome and low FT, the symptoms were significantly improved following combination therapy.
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October-2021
Volume 22 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Takeuchi H and Takeuchi H: Clinical efficiency of combination therapy using testosterone replacement therapy, phosphodiesterase 5 inhibitors and Kampo herbal medicine for eugonadal patients with late‑onset hypogonadism syndrome. Exp Ther Med 22: 1173, 2021
APA
Takeuchi, H., & Takeuchi, H. (2021). Clinical efficiency of combination therapy using testosterone replacement therapy, phosphodiesterase 5 inhibitors and Kampo herbal medicine for eugonadal patients with late‑onset hypogonadism syndrome. Experimental and Therapeutic Medicine, 22, 1173. https://doi.org/10.3892/etm.2021.10608
MLA
Takeuchi, H., Okubo, H."Clinical efficiency of combination therapy using testosterone replacement therapy, phosphodiesterase 5 inhibitors and Kampo herbal medicine for eugonadal patients with late‑onset hypogonadism syndrome". Experimental and Therapeutic Medicine 22.4 (2021): 1173.
Chicago
Takeuchi, H., Okubo, H."Clinical efficiency of combination therapy using testosterone replacement therapy, phosphodiesterase 5 inhibitors and Kampo herbal medicine for eugonadal patients with late‑onset hypogonadism syndrome". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1173. https://doi.org/10.3892/etm.2021.10608