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Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD

  • Authors:
    • Yin Zhang
    • Chunfang Xu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1176
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    Published online on: August 13, 2021
       https://doi.org/10.3892/etm.2021.10610
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Abstract

The incidence of esophageal fibrosis and benign esophageal stricture (BES) has increased in recent years due to the curative therapy for early‑stage esophageal carcinoma, including partial esophagectomy and esophageal endoscopic submucosal dissection (ESD). The aim of the present study was to identify key genes and associated pathways of esophageal fibrosis after the ESD procedure. During the esophageal ESD procedure, the esophageal tissue in the remaining submucosal layer, referred to as normal esophageal (NE) tissue, was collected, and 1 week thereafter, post‑operative esophageal (PE) tissue was obtained. High‑throughput sequencing was used to identify dysregulated microRNAs (miRNAs/miRs) between NE and PE tissues. According to the differentially expressed (DE) miRNAs, putative target genes were predicted. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes enrichment analysis and DEmiRNA interaction network analysis were performed. Reverse transcription‑quantitative PCR (RT‑qPCR) was performed to validate the RNA‑sequencing results. A total of 199 miRNAs were determined to be DE between NE and PE tissues. Compared with the expression in the NE group, 83 miRNAs were significantly upregulated, while 116 miRNAs were significantly downregulated. According to these DE miRNAs, forkhead box O1 (FOXO1), paired box 6 (PAX6), phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit alpha (PIK3CA) and adrenoceptor β1 (ADRB1) were DE genes regulated by five DE miRNAs, including miR‑223‑3p, miR‑142‑5p, miR‑582‑5p, miR‑21‑3p and miR‑218‑5p. The results suggested that certain pathways were markedly dysregulated, including FOXO, MAPK, AMP‑activated protein kinase and signaling pathways regulating the pluripotency of stem cells and proteoglycans in cancer. According to the RT‑qPCR results, the expression levels of FOXO1, PAX6, ADRB1, miR‑223‑3p, miR‑582‑5p, miR‑21‑3p and miR‑218‑5p were consistent with the integrated analysis. In conclusion, FOXO1, PAX6, PIK3CA and ADRB1 may have a role in esophageal fibrosis, regulated by miR‑223‑3p, miR‑142‑5p, miR‑582‑5p, miR‑21‑3p and miR‑218‑5p. The present results provided an improved understanding of the changes in the microenvironment during the process of esophageal fibrosis, as well as novel potential targets for the treatment of esophageal fibrosis and BES.
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1 

Siersema PD: How to approach a patient with refractory or recurrent benign esophageal stricture. Gastroenterology. 156:7–10. 2019.PubMed/NCBI View Article : Google Scholar

2 

Yan X, Nie D, Zhang Y, Chang H and Huang Y: Effectiveness of an orally administered steroid gel at preventing restenosis after endoscopic balloon dilation of benign esophageal stricture. Medicine (Baltimore). 98(e14565)2019.PubMed/NCBI View Article : Google Scholar

3 

Fuccio L, Hassan C, Frazzoni L, Miglio R and Repici A: Clinical outcomes following stent placement in refractory benign esophageal stricture: A systematic review and meta-analysis. Endoscopy. 48:141–148. 2016.PubMed/NCBI View Article : Google Scholar

4 

van Halsema EE, Noordzij IC, van Berge Henegouwen MI, Fockens P, Bergman JJ and van Hooft JE: Endoscopic dilation of benign esophageal anastomotic strictures over 16 mm has a longer lasting effect. Surg Endosc. 31:1871–1881. 2017.PubMed/NCBI View Article : Google Scholar

5 

Haverkamp L, van der Sluis PC, Verhage RJ, Siersema PD, Ruurda JP and van Hillegersberg R: End-to-end cervical esophagogastric anastomoses are associated with a higher number of strictures compared with end-to-side anastomoses. J Gastrointest Surg. 17:872–876. 2013.PubMed/NCBI View Article : Google Scholar

6 

Liao Z, Liao G, Yang X, Peng X, Zhang X, Xie X, Zhao X, Yang S, Fan C and Bai J: Transplantation of autologous esophageal mucosa to prevent stricture after circumferential endoscopic submucosal dissection of early esophageal cancer (with video). Gastrointest Endosc. 88:543–546. 2018.PubMed/NCBI View Article : Google Scholar

7 

Rockey DC, Bell PD and Hill JA: Fibrosis - a common pathway to organ injury and failure. N Engl J Med. 372:1138–1149. 2015.PubMed/NCBI View Article : Google Scholar

8 

Honda M, Nakamura T, Hori Y, Shionoya Y, Nakada A, Sato T, Yamamoto K, Kobayashi T, Shimada H, Kida N, et al: Process of healing of mucosal defects in the esophagus after endoscopic mucosal resection: Histological evaluation in a dog model. Endoscopy. 42:1092–1095. 2010.PubMed/NCBI View Article : Google Scholar

9 

Yates LA, Norbury CJ and Gilbert RJ: The long and short of microRNA. Cell. 153:516–519. 2013.PubMed/NCBI View Article : Google Scholar

10 

Blaya D, Coll M, Rodrigo-Torres D, Vila-Casadesús M, Altamirano J, Llopis M, Graupera I, Perea L, Aguilar-Bravo B, Díaz A, et al: Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation. Gut. 65:1535–1545. 2016.PubMed/NCBI View Article : Google Scholar

11 

Sun Y, Ge Y, Fu Y, Yan L, Cai J, Shi K, Cao X and Lu C: Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE. Eur J Pharmacol. 765:198–208. 2015.PubMed/NCBI View Article : Google Scholar

12 

Wang BB, Xie H, Wu T, Xie N, Wu J, Gu Y, Tang F and Liu J: Controlled-release mitomycin C-polylactic acid film prevents epidural scar hyperplasia after laminectomy by inducing fibroblast autophagy and regulating the expression of miRNAs. Eur Rev Med Pharmacol Sci. 21:2526–2537. 2017.PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

14 

Wu L, Li H, Jia CY, Cheng W, Yu M, Peng M, Zhu Y, Zhao Q, Dong YW, Shao K, et al: MicroRNA-223 regulates FOXO1 expression and cell proliferation. FEBS Lett. 586:1038–1043. 2012.PubMed/NCBI View Article : Google Scholar

15 

Han LL, Zhou XJ, Li FJ, Hao XW, Jiang Z, Dong Q and Chen X: MiR-223-3p promotes the growth and invasion of neuroblastoma cell via targeting FOXO1. Eur Rev Med Pharmacol Sci. 23:8984–8990. 2019.PubMed/NCBI View Article : Google Scholar

16 

Cheng N, Liu C, Li Y, Gao S, Han YC, Wang X, Du J and Zhang C: MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice. J Biol Chem. 295:10212–10223. 2020.PubMed/NCBI View Article : Google Scholar

17 

Liu X, Xu Y, Deng Y and Li H: MicroRNA-223 regulates cardiac fibrosis after myocardial infarction by targeting RASA1. Cell Physiol Biochem. 46:1439–1454. 2018.PubMed/NCBI View Article : Google Scholar

18 

Chen YT, Chen FY, Vijmasi T, Stephens DN, Gallup M and McNamara NA: Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLoS One. 8(e77286)2013.PubMed/NCBI View Article : Google Scholar

19 

Feng Y, Li M, Wang S, Cong W, Hu G, Song Y, Xiao H, Dong E and Zhang Y: Paired box 6 inhibits cardiac fibroblast differentiation. Biochem Biophys Res Commun. 528:561–566. 2020.PubMed/NCBI View Article : Google Scholar

20 

Li C, Tan YH, Sun J, Deng FM and Liu YL: PAX6 contributes to the activation and proliferation of hepatic stellate cells via activating Hedgehog/GLI1 pathway. Biochem Biophys Res Commun. 526:314–320. 2020.PubMed/NCBI View Article : Google Scholar

21 

Kiriazis H, Wang K, Xu Q, Gao XM, Ming Z, Su Y, Moore XL, Lambert G, Gibbs ME, Dart AM, et al: Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis. Br J Pharmacol. 153:684–692. 2008.PubMed/NCBI View Article : Google Scholar

22 

Ito A, Ohnuki Y, Suita K, Ishikawa M, Mototani Y, Shiozawa K, Kawamura N, Yagisawa Y, Nariyama M, Umeki D, et al: Role of β-adrenergic signaling in masseter muscle. PLoS One. 14(e0215539)2019.PubMed/NCBI View Article : Google Scholar

23 

Steiner JE, Cottrell CE, Streicher JL, Jensen JN, King DM, Burrows PE, Siegel DH, Tollefson MM, Drolet BA and Püttgen KB: Scarring in patients With PIK3CA-related overgrowth syndromes. JAMA Dermatol. 154:452–455. 2018.PubMed/NCBI View Article : Google Scholar

24 

Yang X, Li X, Lin Q and Xu Q: Up-regulation of microRNA-203 inhibits myocardial fibrosis and oxidative stress in mice with diabetic cardiomyopathy through the inhibition of PI3K/Akt signaling pathway via PIK3CA. Gene. 715(143995)2019.PubMed/NCBI View Article : Google Scholar

25 

Wegner KA, Mueller BR, Unterberger CJ, Avila EJ, Ruetten H, Turco AE, Oakes SR, Girardi NM, Halberg RB, Swanson SM, et al: Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation. J Pathol. 250:231–242. 2020.PubMed/NCBI View Article : Google Scholar

26 

Zhu J, Zhou L, Wei B, Qian Z, Wang J, Hui H and Sun Y: miR-142-5p inhibits pancreatic cancer cell migration and invasion by targeting PIK3CA. Mol Med Rep. 22:2085–2092. 2020.PubMed/NCBI View Article : Google Scholar

27 

Cai L, Chao G, Li W, Zhu J, Li F, Qi B, Wei Y, Chen S, Zhou G, Lu X, et al: Activated CD4+ T cells-derived exosomal miR-142-3p boosts post-ischemic ventricular remodeling by activating myofibroblast. Aging (Albany NY). 12:7380–7396. 2020.PubMed/NCBI View Article : Google Scholar

28 

Guiot J, Cambier M, Boeckx A, Henket M, Nivelles O, Gester F, Louis E, Malaise M, Dequiedt F, Louis R, et al: Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of antifibrotic miR-142-3p. Thorax. 75:870–881. 2020.PubMed/NCBI View Article : Google Scholar

29 

Wang Z, Liu Z, Fang X and Yang H: MiR-142-5p suppresses tumorigenesis by targeting PIK3CA in non-small cell lung cancer. Cell Physiol Biochem. 43:2505–2515. 2017.PubMed/NCBI View Article : Google Scholar

30 

Mei J, Zhang Y, Lu S and Wang J: Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis. Biomed Pharmacother. 129(110326)2020.PubMed/NCBI View Article : Google Scholar

31 

Vuppalanchi R, Liang T, Goswami CP, Nalamasu R, Li L, Jones D, Wei R, Liu W, Sarasani V, Janga SC, et al: Relationship between differential hepatic microRNA expression and decreased hepatic cytochrome P450 3A activity in cirrhosis. PLoS One. 8(e74471)2013.PubMed/NCBI View Article : Google Scholar

32 

Yang F, Luo L, Zhu ZD, Zhou X, Wang Y, Xue J, Zhang J, Cai X, Chen ZL, Ma Q, et al: Chlorogenic acid inhibits liver fibrosis by blocking the miR-21-regulated TGF-β1/Smad7 signaling pathway in vitro and in vivo. Front Pharmacol. 8(929)2017.PubMed/NCBI View Article : Google Scholar

33 

Zhou XL, Xu H, Liu ZB, Wu QC, Zhu RR and Liu JC: miR-21 promotes cardiac fibroblast-to-myofibroblast transformation and myocardial fibrosis by targeting Jagged1. J Cell Mol Med. 22:3816–3824. 2018.PubMed/NCBI View Article : Google Scholar

34 

Sun C, Tian J, Liu X and Guan G: MiR-21 promotes fibrosis and hypertrophy of ligamentum flavum in lumbar spinal canal stenosis by activating IL-6 expression. Biochem Biophys Res Commun. 490:1106–1111. 2017.PubMed/NCBI View Article : Google Scholar

35 

Conickx G, Mestdagh P, Avila Cobos F, Verhamme FM, Maes T, Vanaudenaerde BM, Seys LJ, Lahousse L, Kim RY, Hsu AC, et al: MicroRNA profiling reveals a role for MicroRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 195:43–56. 2017.PubMed/NCBI View Article : Google Scholar

36 

Li Z, Qian R, Zhang J and Shi X: MiR-218-5p targets LHFPL3 to regulate proliferation, migration, and epithelial-mesenchymal transitions of human glioma cells. Biosci Rep. 39(BSR20180879)2019.PubMed/NCBI View Article : Google Scholar

37 

Brkić J, Dunk C, O'Brien J, Fu G, Nadeem L, Wang YL, Rosman D, Salem M, Shynlova O, Yougbaré I, et al: MicroRNA-218-5p promotes endovascular trophoblast differentiation and spiral artery remodeling. Mol Ther. 26:2189–2205. 2018.PubMed/NCBI View Article : Google Scholar

38 

Han S, Chen Y, Gao Y, Sun B and Kong Y: MicroRNA-218-5p inhibit the migration and proliferation of pterygium epithelial cells by targeting EGFR via PI3K/Akt/mTOR signaling pathway. Exp Eye Res. 178:37–45. 2019.PubMed/NCBI View Article : Google Scholar

39 

Baker Frost D, Savchenko A, Ogunleye A, Armstrong M and Feghali-Bostwick C: Elucidating the cellular mechanism for E2-induced dermal fibrosis. Arthritis Res Ther. 23(68)2021.PubMed/NCBI View Article : Google Scholar

40 

Zhang Z, Zhu D, Zhang X, Liu Y, Wang J and Yan L: Tanshinone IIA regulates fibroblast proliferation and migration and post-surgery arthrofibrosis through the autophagy-mediated PI3K and AMPK-mTOR signaling pathway. Am J Transl Res. 13:565–584. 2021.PubMed/NCBI

41 

Qi L, He W, Yang J, Gao Y and Chen J: Endoscopic balloon dilation and submucosal injection of triamcinolone acetonide in the treatment of esophageal stricture: A single-center retrospective study. Exp Ther Med. 16:5248–5252. 2018.PubMed/NCBI View Article : Google Scholar

42 

Zhang Y, Wang X, Liu L, Chen JP and Fan ZN: Intramuscular injection of mitomycin C combined with endoscopic dilation for benign esophageal strictures. J Dig Dis. 16:370–376. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y and Xu C: Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD. Exp Ther Med 22: 1176, 2021.
APA
Zhang, Y., & Xu, C. (2021). Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD. Experimental and Therapeutic Medicine, 22, 1176. https://doi.org/10.3892/etm.2021.10610
MLA
Zhang, Y., Xu, C."Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD". Experimental and Therapeutic Medicine 22.4 (2021): 1176.
Chicago
Zhang, Y., Xu, C."Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1176. https://doi.org/10.3892/etm.2021.10610
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y and Xu C: Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD. Exp Ther Med 22: 1176, 2021.
APA
Zhang, Y., & Xu, C. (2021). Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD. Experimental and Therapeutic Medicine, 22, 1176. https://doi.org/10.3892/etm.2021.10610
MLA
Zhang, Y., Xu, C."Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD". Experimental and Therapeutic Medicine 22.4 (2021): 1176.
Chicago
Zhang, Y., Xu, C."Integrative analysis of miRNA‑mRNA expression profiles in esophageal fibrosis after ESD". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1176. https://doi.org/10.3892/etm.2021.10610
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