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Article

Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study

  • Authors:
    • Mefkur Bakan
    • Tarik Umutoglu
    • Ufuk Topuz
    • Emine Yilmaz Guler
    • Harun Uysal
    • Erdogan Ozturk
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Vocational School of Health Services, Istanbul Rumeli University, Silivri, Istanbul 34570, Turkey, Deparment of Anesthesiology, Istanbul Health and Technology University, Zeytinburnu, Istanbul 34015, Turkey, Department of Anesthesiology, Ministry of Health Haseki Training and Research Hospital, Fatih, Istanbul 34130, Turkey, Department of Anesthesiology, Bezmialem Vakif University, Fatih, Istanbul 34093, Turkey, Department of Anesthesiology, Türk Böbrek Vakfı Memorial Hizmet Hospital, Bahçelievler, Istanbul 34180, Turkey
  • Article Number: 1198
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    Published online on: August 23, 2021
       https://doi.org/10.3892/etm.2021.10632
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Abstract

Application of total intravenous anesthesia (TIVA) may be considered as unpractical when compared with inhalational anesthesia. Although it is mostly not recommended, mixing intravenous agents is popular in clinical practice. The aim of the present study was to investigate the suitability of using remifentanil‑propofol mixture (MIXTIVA) for TIVA. Adult patients with an American Society of Anesthesiologists grade of I‑II scheduled for elective thyroidectomy were randomly allocated to 3 groups (n=32 for each) to receive TIVA with remifentanil and propofol infusions separately (control group, Group I) or with MIXTIVA infusion that contained remifentanil/propofol at a proportion of 2/1,000 or 3/1,000 (remifentanil concentration, 20 or 30 µg/ml in 1% propofol in Group II or Group III, respectively). The extubation time (the primary outcome of the study), the orientation time and number of patients in whom intraoperative hypotension, hypertension or bradycardia episodes were encountered during anesthesia were comparable among the groups. The mean remifentanil infusion rate in Group III was significantly higher than that in the other groups. The mean propofol infusion rates and mean bispectral index (BIS) scores during anesthesia were comparable among groups. Hypotension accompanied with a high BIS was encountered in one patient in Group III. In conclusion, compared to the standard TIVA technique using separate drug infusions, MIXTIVA infusion used for thyroidectomies did not result in any statistically significant difference in recovery and clinical outcomes. This technique may be considered as a practical implementation for busy ambulatory centers performing general anesthesia. The present study was retrospectively registered at clinicaltrials.gov (trial registration no. NCT04394897).
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1 

Anderson BJ and Bagshaw O: Practicalities of total intravenous anesthesia and target-controlled infusion in children. Anesthesiology. 131:164–185. 2019.PubMed/NCBI View Article : Google Scholar

2 

Roberts FL, Dixon J, Lewis GT, Tackley RM and Prys-Roberts C: Induction and maintenance of propofol anaesthesia. A manual infusion scheme. Anaesthesia. 43 (Suppl):S14–S17. 1988.PubMed/NCBI View Article : Google Scholar

3 

Bagshaw O, McCormack J, Brooks P, Marriott D and Baxter A: The safety profile and effectiveness of propofol-remifentanil mixtures for total intravenous anesthesia in children. Paediatr Anaesth. 30:1331–1339. 2020.PubMed/NCBI View Article : Google Scholar

4 

Bagshaw O: Pediatric anesthesia editorial-propofol and remifentanil: To mix or not to mix. Paediatr Anaesth. 26:677–679. 2016.PubMed/NCBI View Article : Google Scholar

5 

Goudra BG, Singh PM and Sinha A: Providing anesthesia in a remote location for radiation oncology in an adult-Problems and solutions. J Anaesthesiol Clin Pharmacol. 30:114–116. 2014.PubMed/NCBI View Article : Google Scholar

6 

Pedersen NA, Jensen AG, Kilmose L and Olsen KS: Propofol-remifentanil or sevoflurane for children undergoing magnetic resonance imaging? A randomized study. Acta Anaesthesiol Scand. 57:988–995. 2013.PubMed/NCBI View Article : Google Scholar

7 

Lan C, Shen X, Cui H, Liu H, Li P, Wan X, Lan L and Chen D: Comparison of nitrous oxide to no sedation and deep sedation for diagnostic upper gastrointestinal endoscopy. J Gastrointest Surg. 17:1066–1072. 2013.PubMed/NCBI View Article : Google Scholar

8 

Kramer KJ, Ganzberg S, Prior S and Rashid RG: Comparison of propofol-remifentanil versus propofol-ketamine deep sedation for third molar surgery. Anesth Prog. 59:107–117. 2012.PubMed/NCBI View Article : Google Scholar

9 

Joo JD, In JH, Kim DW, Jung HS, Kang JH, Yeom JH, Yeom JH and Choi JW: The comparison of sedation quality, side effect and recovery profiles on different dosage of remifentanil patient-controlled sedation during breast biopsy surgery. Korean J Anesthesiol. 63:431–435. 2012.PubMed/NCBI View Article : Google Scholar

10 

Mazanikov M, Udd M, Kylänpää L, Mustonen H, Lindström O, Halttunen J, Färkkilä M and Pöyhiä R: Patient-controlled sedation for ERCP: A randomized double-blind comparison of alfentanil and remifentanil. Endoscopy. 44:487–492. 2012.PubMed/NCBI View Article : Google Scholar

11 

Ryu JH, Kim M, Bahk JH, Do SH, Cheong IY and Kim YC: A comparison of retrobulbar block, sub-Tenon block, and topical anesthesia during cataract surgery. Eur J Ophthalmol. 19:240–246. 2009.PubMed/NCBI View Article : Google Scholar

12 

Mandel JE, Tanner JW, Lichtenstein GR, Metz DC, Katzka DA, Ginsberg GG and Kochman ML: A randomized, controlled, double-blind trial of patient-controlled sedation with propofol/remifentanil versus midazolam/fentanyl for colonoscopy. Anesth Analg. 106:434–439. 2008.PubMed/NCBI View Article : Google Scholar

13 

Melville D, Hartsilver EL and Hart A: Bolus dosing of remifentanil with propofol for gynaecological day case surgery. J One Day Surg. 18:88–91. 2008.PubMed/NCBI View Article : Google Scholar

14 

Tsui BC, Wagner A, Usher AG, Cave DA and Tang C: Combined propofol and remifentanil intravenous anesthesia for pediatric patients undergoing magnetic resonance imaging. Paediatr Anaesth. 15:397–401. 2005.PubMed/NCBI View Article : Google Scholar

15 

Brady WJ, Meenan DR, Shankar TR, Balon JA and Mennett DR: Use of a remifentanil and propofol combination in outpatients to facilitate rapid discharge home. AANA J. 73:207–210. 2005.PubMed/NCBI

16 

Berkenbosch JW, Graff GR, Stark JM, Ner Z and Tobias JD: Use of a remifentanil-propofol mixture for pediatric flexible fiberoptic bronchoscopy sedation. Paediatr Anaesth. 14:941–946. 2004.PubMed/NCBI View Article : Google Scholar

17 

Joo HS, Perks WJ, Kataoka MT, Errett L, Pace K and Honey RJ: A comparison of patient-controlled sedation using either remifentanil or remifentanil-propofol for shock wave lithotripsy. Anesth Analg. 93:1227–1232. 2001.PubMed/NCBI View Article : Google Scholar

18 

Fish WH, Hobbs AJ and Daniels MV: Comparison of sevoflurane and total intravenous anaesthesia for daycase urological surgery. Anaesthesia. 54:999–1006. 1999.PubMed/NCBI View Article : Google Scholar

19 

Anderson BJ and Houghton J: Total intravenous anesthesia and target-controlled infusion. In: A Practice of Anesthesia for infants and children. 6th edition. Cote CJ, Lerman J and Anderson BJ (eds). Elsevier, pp177-198, 2019.

20 

Bennett JD and Butterfield K: Anesthetic concepts and techniques. Vol. 1. In: Oral and Maxillofacial Surgery. 3rd edition. Fonseca RJ (ed). Elsevier, St. Louis, MO, pp211-224, 2018.

21 

Robert RC, Liu S, Patel C and Gonzalez ML: Advancements in office-based anesthesia in oral and maxillofacial surgery. Atlas Oral Maxillofac Surg Clin North Am. 21:139–165. 2013.PubMed/NCBI View Article : Google Scholar

22 

Urman RD and Shapiro FE: Choosing anesthetic agents. Which one? In: Manual of Office-Based Anesthesia Procedures. Shapiro FE (ed). Lippincott Williams & Wilkins, Philadelphia, PA, pp58-74, 2007.

23 

https://www.rch.org.au/uploadedFiles/Main/Content/anaes/TIVA%20for%20tonsillectomy%202014.pdf. Assessed October, 2020.

24 

http://www.anesthesiologynews.com/ViewArticle.aspx?d_id=1&a_id=14586&ses=ogst. Assessed October, 2020.

25 

http://ether.stanford.edu/library/pediatric_anesthesia/anesthetic%20techniques/guideline-tiva.pdf. Assessed October, 2020.

26 

Stewart JT, Warren FW, Maddox FC, Viswanathan K and Fox JL: The stability of remifentanil hydrochloride and propofol mixtures in polypropylene syringes and polyvinylchloride bags at 22 degrees-24 degrees C. Anesth Analg. 90:1450–1451. 2000.PubMed/NCBI View Article : Google Scholar

27 

O'Connor S, Zhang YL, Christians U, Morrison JE Jr and Friesen RH: Remifentanil and propofol undergo separation and layering when mixed in the same syringe for total intravenous anesthesia. Paediatr Anaesth. 26:703–709. 2016.PubMed/NCBI View Article : Google Scholar

28 

Wilson RJ and Ridley SA: The use of propofol and alfentanil by infusion in military anaesthesia. Anaesthesia. 47:231–233. 1992.PubMed/NCBI View Article : Google Scholar

29 

Collins SJ, Robinson AL and Holland HF: A comparison between total intravenous anaesthesia using a propofol/alfentanil mixture and an inhalational technique for laparoscopic gynaecological sterilization. Eur J Anaesthesiol. 13:33–37. 1996.PubMed/NCBI View Article : Google Scholar

30 

Weatherall A and Venclovas R: Experience with a propofol-ketamine mixture for sedation during pediatric orthopedic surgery. Paediatr Anaesth. 20:1009–1016. 2010.PubMed/NCBI View Article : Google Scholar

31 

Lamperti M: Adult procedural sedation: An update. Curr Opin Anaesthesiol. 28:662–667. 2015.PubMed/NCBI View Article : Google Scholar

32 

Ghojazadeh M, Sanaie S, Paknezhad SP, Faghih SS and Soleimanpour H: Using ketamine and propofol for procedural sedation of adults in the emergency department: A systematic review and meta-analysis. Adv Pharm Bull. 9:5–11. 2019.PubMed/NCBI View Article : Google Scholar

33 

Fahringer DL, Goodwin SR, Warde MK, Ye G, Blackwelder B, Ajala AM and Gurgis FS: The effect of a 3: 1 volume mixture of propofol 1% and thiopental 2.5% in reducing the pain on injection of propofol in children. Paediatr Anaesth. 20:545–552. 2010.PubMed/NCBI View Article : Google Scholar

34 

Austin JD and Parke TJ: Admixture of ephedrine to offset side effects of propofol: A randomized, controlled trial. J Clin Anesth. 21:44–49. 2009.PubMed/NCBI View Article : Google Scholar

35 

Thompson N and Robertson GS: Comparison of propofol and a propofol-methohexitone mixture for induction of day-case anaesthesia. Br J Anaesth. 77:213–216. 1996.PubMed/NCBI View Article : Google Scholar

36 

Mecklem DW: Propofol injection pain: Comparing the addition of lignocaine or metoclopramide. Anaesth Intens Care. 22:568–570. 1994.PubMed/NCBI View Article : Google Scholar

37 

Unlugenc H, Tetiker S and Isik G: Addition of remifentanil to patient-controlled tramadol for postoperative analgesia: A double-blind, controlled, randomized trial after major abdominal surgery. Eur J Anaesthesiol. 25:968–975. 2008.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Bakan M, Umutoglu T, Topuz U, Guler EY, Uysal H and Ozturk E: Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study. Exp Ther Med 22: 1198, 2021.
APA
Bakan, M., Umutoglu, T., Topuz, U., Guler, E.Y., Uysal, H., & Ozturk, E. (2021). Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study. Experimental and Therapeutic Medicine, 22, 1198. https://doi.org/10.3892/etm.2021.10632
MLA
Bakan, M., Umutoglu, T., Topuz, U., Guler, E. Y., Uysal, H., Ozturk, E."Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study". Experimental and Therapeutic Medicine 22.5 (2021): 1198.
Chicago
Bakan, M., Umutoglu, T., Topuz, U., Guler, E. Y., Uysal, H., Ozturk, E."Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1198. https://doi.org/10.3892/etm.2021.10632
Copy and paste a formatted citation
x
Spandidos Publications style
Bakan M, Umutoglu T, Topuz U, Guler EY, Uysal H and Ozturk E: Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study. Exp Ther Med 22: 1198, 2021.
APA
Bakan, M., Umutoglu, T., Topuz, U., Guler, E.Y., Uysal, H., & Ozturk, E. (2021). Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study. Experimental and Therapeutic Medicine, 22, 1198. https://doi.org/10.3892/etm.2021.10632
MLA
Bakan, M., Umutoglu, T., Topuz, U., Guler, E. Y., Uysal, H., Ozturk, E."Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study". Experimental and Therapeutic Medicine 22.5 (2021): 1198.
Chicago
Bakan, M., Umutoglu, T., Topuz, U., Guler, E. Y., Uysal, H., Ozturk, E."Prospective evaluation of remifentanil‑propofol mixture for total intravenous anesthesia: A randomized controlled study". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1198. https://doi.org/10.3892/etm.2021.10632
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