Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway

  • Authors:
    • Zheng-Yu Liu
    • Qiu-Xia Yang
    • Yan Cao
    • Hong-Wei Pan
    • Jing-Jing Rong
    • Jing Ling
    • Yi Tang
    • Jin He
    • Chang-Lu Wang
    • Xiang Peng
    • Qiong-Chao Zou
    • Le Zhang
    • Jiao Zheng
    • Jia Wang
    • Yu Zhang
    • Jian-Qiang Peng
    • Lan-Bing Xiong
    • Feng Liu
    • Zi-Hui Ying
    • Zhao-Fen Zheng
    • Bai-Ling Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Hunan Provincial People's Hospital, Changsha, Hunan 410000, P.R. China, Department of Cardiology, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, Hunan 410000, P.R. China, Department of Emergency, Hunan Provincial People's Hospital, Changsha, Hunan 410000, P.R. China, Institute of Clinical Pharmacology Research, Hunan Provincial People's Hospital, Changsha, Hunan 410000, P.R. China, Department of Cardiology, Xiangxi Autonomous Prefecture People's Hospital, Jishou, Hunan 416000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 1200
    |
    Published online on: August 23, 2021
       https://doi.org/10.3892/etm.2021.10634
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the regulatory mechanism of chemokine (C‑X‑C motif) receptor 4 (CXCR4) on endothelial progenitor cells (EPCs) through the phosphatidylinositol 3‑kinase/protein kinase B (PI3K/Akt) signaling pathway under hypoxic conditions. Mononuclear cells were isolated from the bone marrow (BM) of young Sprague‑Dawley (SD) rats. Bone marrow‑derived endothelial progenitor cells (BM‑EPCs) were characterized by using Dil‑labeled acetylated low‑density lipoprotein (Dil‑ac‑LDL) and fluorescein isothiocyanate‑labeled UEA (FITC‑UEA‑1). Phenotype identification of BM‑EPCs was based on red cytoplasm and green cytomembrane. Flow cytometry was employed to examine the markers CD14, CD34, and KDR. Expression level of the EPC‑specific surface marker CD14 was found to be negative, while the expression level of CD34 and KDR was positive. In addition, CXCR4 was stably overexpressed in BM‑EPCs after transfection with adenovirus‑CXCR4. Cell proliferation, migration and apoptosis abilities were measured through the application of CCK‑8, followed by Transwell and flow cytometry assays. The expression level of CXCR4, PI3K and Akt was determined by reverse transcription‑quantitative PCR and western blotting assays. Functional experiments demonstrated that hypoxia inhibited BM‑EPC proliferation and migration, while accelerating BM‑EPC apoptosis. Additionally, CXCR4 was found to promote proliferation and migration, and suppress apoptosis in BM‑EPCs with or without hypoxia treatment. Evidence also demonstrated that CXCR4 markedly upregulated the expression levels of PI3K and Akt. Furthermore, PI3K inhibitor (LY294002) and CXCR4 inhibitor (AMD3100) effectively inhibited the proliferation, migration and resistance to apoptosis of CXCR4‑mediated BM‑EPCs under hypoxic conditions.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: A systematic analysis for the global burden of disease study 2016. Lancet. 390:1151–1210. 2017.PubMed/NCBI View Article : Google Scholar

2 

Townsend N, Wilson L, Bhatnagar P, Wickramasinghe K, Rayner M and Nichols M: Cardiovascular disease in Europe: Epidemiological update 2016. Eur Heart J. 37:3232–3245. 2016.PubMed/NCBI View Article : Google Scholar

3 

Ramakrishnan S, Anand V and Roy S: Vascular endothelial growth factor signaling in hypoxia and inflammation. J Neuroimmune Pharmacol. 9:142–60. 2014.PubMed/NCBI View Article : Google Scholar

4 

Jaipersad AS, Lip GY, Silverman S and Shantsila E: The role of monocytes in angiogenesis and atherosclerosis. J Am Coll Cardiol. 63:1–11. 2014.PubMed/NCBI View Article : Google Scholar

5 

Sharifpanah F, Behr S, Wartenberg M and Sauer H: Mechanical strain stimulates vasculogenesis and expression of angiogenesis guidance molecules of embryonic stem cells through elevation of intracellular calcium, reactive oxygen species and nitric oxide generation. Biochim Biophys Acta. 1863:3096–3105. 2016.PubMed/NCBI View Article : Google Scholar

6 

Rafii S, Butler JM and Ding BS: Angiocrine functions of organ-specific endothelial cells. Nature. 529:316–325. 2016.PubMed/NCBI View Article : Google Scholar

7 

Döring Y, Pawig L, Weber C and Noels H: The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease. Front Physiol. 5(212)2014.PubMed/NCBI View Article : Google Scholar

8 

Schober A and Zernecke A: Chemokines in vascular remodeling. Thromb Haemost. 97:730–737. 2007.PubMed/NCBI

9 

Jacobson O and Weiss ID: CXCR4 chemokine receptor overview: Biology, pathology and applications in imaging and therapy. Theranostics. 3:1–2. 2013.PubMed/NCBI View Article : Google Scholar

10 

Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, Murasawa S, Bosch-Marce M, Masuda H, Losordo DW, Isner JM and Asahara T: Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation. 107:1322–1328. 2003.PubMed/NCBI View Article : Google Scholar

11 

Segal MS, Shah R, Afzal A, Perrault CM, Chang K, Schuler A, Beem E, Shaw LC, Li Calzi S, Harrison JK, et al: Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes. Diabetes. 55:102–109. 2006.PubMed/NCBI

12 

Navidshad B, Liang JB and Jahromi MF: Correlation coefficients between different methods of expressing bacterial quantification using real time PCR. Int J Mol Sci. 13:2119–2132. 2012.PubMed/NCBI View Article : Google Scholar

13 

Matsuzawa Y, Guddeti RR, Kwon TG, Lerman LO and Lerman A: Treating coronary disease and the impact of endothelial dysfunction. Prog Cardiovasc Dis. 57:431–442. 2015.PubMed/NCBI View Article : Google Scholar

14 

Dai Z, Li M, Wharton J, Zhu MM and Zhao YY: Prolyl-4 hydroxylase 2 (PHD2) deficiency in endothelial cells and hematopoietic cells induces obliterative vascular remodeling and severe pulmonary arterial hypertension in mice and humans through hypoxia-inducible factor-2α. Circulation. 133:2447–2458. 2016.PubMed/NCBI View Article : Google Scholar

15 

Cesari F, Sofi F, Molino Lova R, Vannetti F, Pasquini G, Cecchi F, Marcucci R, Gori AM and Macchi C: Mugello Study Working Group. Aging process, adherence to mediterranean diet and nutritional status in a large cohort of nonagenarians: Effects on endothelial progenitor cells. Nutr Metab Cardiovasc Dis. 28:84–90. 2018.PubMed/NCBI View Article : Google Scholar

16 

Dai X, Yan X, Zeng J, Chen J, Wang Y, Chen J, Li Y, Barati MT, Wintergerst KA, Pan K, et al: Elevating CXCR7 improves angiogenic function of EPCs via Akt/GSK-3β/Fyn-mediated Nrf2 activation in diabetic limb ischemia. Circ Res. 120:e7–e23. 2017.PubMed/NCBI View Article : Google Scholar

17 

Bianconi V, Sahebkar A, Kovanen P, Bagaglia F, Ricciuti B, Calabrò P, Patti G and Pirro M: Endothelial and cardiac progenitor cells for cardiovascular repair: A controversial paradigm in cell therapy. Pharmacol Ther. 181:156–168. 2018.PubMed/NCBI View Article : Google Scholar

18 

Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Böhm M and Nickenig G: Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med. 353:999–1007. 2005.PubMed/NCBI View Article : Google Scholar

19 

Napoli C, Hayashi T, Cacciatore F, Casamassimi A, Casini C, Al-Omran M and Ignarro LJ: Endothelial progenitor cells as therapeutic agents in the microcirculation: An update. Atherosclerosis. 215:9–22. 2011.PubMed/NCBI View Article : Google Scholar

20 

Wara AK, Manica A, Marchini JF, Sun X, Icli B, Tesmenitsky Y, Croce K and Feinberg MW: Bone marrow-derived Kruppel-like factor 10 controls reendothelialization in response to arterial injury. Arterioscler Thromb Vasc Biol. 33:1552–1560. 2013.PubMed/NCBI View Article : Google Scholar

21 

Ruiz A, Ruiz L, Colón-Caraballo M, Torres-Collazo BJ, Monteiro JB, Bayona M, Fazleabas AT and Flores I: Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion. Biol Reprod. 98:4–14. 2018.PubMed/NCBI View Article : Google Scholar

22 

Bianchi ME and Mezzapelle R: The chemokine receptor CXCR4 in cell proliferation and tissue regeneration. Front Immunol. 11(2109)2020.PubMed/NCBI View Article : Google Scholar

23 

Zheng H, Dai T, Zhou B, Zhu J, Huang H, Wang M and Fu G: SDF-1alpha/CXCR4 decreases endothelial progenitor cells apoptosis under serum deprivation by PI3K/Akt/eNOS pathway. Atherosclerosis. 201:36–42. 2008.PubMed/NCBI View Article : Google Scholar

24 

Manning BD and Toker A: AKT/PKB signaling: Navigating the network. Cell. 169:381–405. 2017.PubMed/NCBI View Article : Google Scholar

25 

Walton KL, Holt L and Sartor RB: Lipopolysaccharide activates innate immune responses in murine intestinal myofibroblasts through multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol. 296:G601–G611. 2009.PubMed/NCBI View Article : Google Scholar

26 

Wang YQ, Zhang JR, Li SD, He YY, Yang YX, Liu XL and Wan XP: Aberrant methylation of breast and ovarian cancer susceptibility gene 1 in chemosensitive human ovarian cancer cells does not involve the phosphatidylinositol 3'-kinase-Akt pathway. Cancer Sci. 101:1618–1623. 2010.PubMed/NCBI View Article : Google Scholar

27 

Polivka J Jr and Janku F: Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther. 142:164–175. 2014.PubMed/NCBI View Article : Google Scholar

28 

Zhou W, Guo S, Liu M, Burow ME and Wang G: Targeting CXCL12/CXCR4 axis in tumor immunotherapy. Curr Med Chem. 26:3026–3041. 2019.PubMed/NCBI View Article : Google Scholar

29 

Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL and Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 121:335–348. 2005.PubMed/NCBI View Article : Google Scholar

30 

Cheng L, Huang Z, Zhou W, Wu Q, Donnola S, Liu JK, Fang X, Sloan AE, Mao Y, Lathia JD, et al: Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell. 153:139–152. 2013.PubMed/NCBI View Article : Google Scholar

31 

Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z and Bergers G: HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 13:206–220. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Yang Q, Cao Y, Pan H, Rong J, Ling J, Tang Y, He J, Wang C, Peng X, Peng X, et al: CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway. Exp Ther Med 22: 1200, 2021.
APA
Liu, Z., Yang, Q., Cao, Y., Pan, H., Rong, J., Ling, J. ... Zhang, B. (2021). CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway. Experimental and Therapeutic Medicine, 22, 1200. https://doi.org/10.3892/etm.2021.10634
MLA
Liu, Z., Yang, Q., Cao, Y., Pan, H., Rong, J., Ling, J., Tang, Y., He, J., Wang, C., Peng, X., Zou, Q., Zhang, L., Zheng, J., Wang, J., Zhang, Y., Peng, J., Xiong, L., Liu, F., Ying, Z., Zheng, Z., Zhang, B."CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway". Experimental and Therapeutic Medicine 22.5 (2021): 1200.
Chicago
Liu, Z., Yang, Q., Cao, Y., Pan, H., Rong, J., Ling, J., Tang, Y., He, J., Wang, C., Peng, X., Zou, Q., Zhang, L., Zheng, J., Wang, J., Zhang, Y., Peng, J., Xiong, L., Liu, F., Ying, Z., Zheng, Z., Zhang, B."CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1200. https://doi.org/10.3892/etm.2021.10634
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Yang Q, Cao Y, Pan H, Rong J, Ling J, Tang Y, He J, Wang C, Peng X, Peng X, et al: CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway. Exp Ther Med 22: 1200, 2021.
APA
Liu, Z., Yang, Q., Cao, Y., Pan, H., Rong, J., Ling, J. ... Zhang, B. (2021). CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway. Experimental and Therapeutic Medicine, 22, 1200. https://doi.org/10.3892/etm.2021.10634
MLA
Liu, Z., Yang, Q., Cao, Y., Pan, H., Rong, J., Ling, J., Tang, Y., He, J., Wang, C., Peng, X., Zou, Q., Zhang, L., Zheng, J., Wang, J., Zhang, Y., Peng, J., Xiong, L., Liu, F., Ying, Z., Zheng, Z., Zhang, B."CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway". Experimental and Therapeutic Medicine 22.5 (2021): 1200.
Chicago
Liu, Z., Yang, Q., Cao, Y., Pan, H., Rong, J., Ling, J., Tang, Y., He, J., Wang, C., Peng, X., Zou, Q., Zhang, L., Zheng, J., Wang, J., Zhang, Y., Peng, J., Xiong, L., Liu, F., Ying, Z., Zheng, Z., Zhang, B."CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxia through the PI3K/Akt signaling pathway". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1200. https://doi.org/10.3892/etm.2021.10634
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team