Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma

  • Authors:
    • Hongbo Wang
    • Zhendong Liu
    • Ang Li
    • Jialin Wang
    • Jiantao Liu
    • Binfeng Liu
    • Xiaoyu Lian
    • Bo Zhang
    • Bo Pang
    • Liyun Liu
    • Yanzheng Gao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics and Microbiome Laboratory, Henan University People's Hospital, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China, Department of Orthopedics and Microbiome Laboratory, Henan University People's Hospital, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China, Department of Neurosurgery, The Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, P.R. China, Department of Orthopaedics, Orthopedic Hospital of Henan Province, Zhengzhou, Henan 450018, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1224
    |
    Published online on: August 27, 2021
       https://doi.org/10.3892/etm.2021.10658
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Studies have indicated that collagen α‑1 (IV) chain (COL4A1) has an indispensable regulatory role in the complex pathological mechanisms of numerous types of malignant tumor. However, its role in the development of glioma has remained elusive. Therefore, the present study sought to determine the association between the expression levels of COL4A1 and the clinical characteristics of gliomas by analyzing large samples. First, analysis of thousands of glioma tissue samples collected from the Gene expression profiling interactive analysis, Gene Expression Omnibus database, the Ivy glioblastoma atlas, The Human Protein Atlas, Chinese Glioma Genome Atlas and The Cancer Genome Atlas. In addition, glioma tissues and normal brain tissues from patients with glioma and epilepsy undergoing surgical resection were collected. These samples, which were subjected to a variety of different detection techniques (including sequencing data, chip data, reverse transcription‑quantitative PCR, cell lines and tissue samples, in situ hybridization and immunology) revealed that COL4A1 expression was not only increased at the mRNA level but also at the protein level as compared with that in normal brain tissue. Furthermore, Kaplan‑Meier analysis revealed that COL4A1 expression was associated with reduced overall survival of patients, particularly those with World Health Organization grade III glioma. Receiver operating characteristic analysis suggested that COL4A1 had a moderate diagnostic value for glioma. In addition, the Mann‑Whitney U‑test or Kruskal‑Wallis test indicated that the expression levels of COL4A1 were positively associated with the histological type and historical grade of the tumor, patient age, ‘Primary, Recurrent, Secondary’ type and the chemotherapy status, and negatively associated with isocitrate dehydrogenase mutation and 1p19q co‑deletion (P<0.001). Gene‑set enrichment analysis indicated that overexpression of COL4A1 promoted cancer‑associated pathways, such as the JAK/STAT signaling pathway and cell cycle regulation. Finally, an MTT assay, immunohistochemical analysis of the cell cycle regulator KI67 and a wound‑healing assay further confirmed that knockdown of COL4A1 inhibited the proliferation and migration ability of glioma cells. In conclusion, COL4A1, as a novel oncogene, is a marker for poor prognosis in patients with glioma. The present study expanded the understanding of the pathogenesis of glioma and identified COL4A1 as a potential target for the diagnosis and treatment of gliomas.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, Stroup NE, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010. NeuroOncol. 15 (Suppl 2):ii1–ii56. 2013.PubMed/NCBI View Article : Google Scholar

2 

Ohgaki H and Kleihues P: Epidemiology and etiology of gliomas. Acta Neuropathol. 109:93–108. 2005.PubMed/NCBI View Article : Google Scholar

3 

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, et al: The epidemiology of glioma in adults: A ‘state of the science’ review. Neuro Oncol. 16:896–913. 2014.PubMed/NCBI View Article : Google Scholar

4 

Claus EB and Black PM: Survival rates and patterns of care for patients diagnosed with supratentorial low-grade gliomas: Data from the SEER program, 1973-2001. Cancer. 106:1358–1363. 2006.PubMed/NCBI View Article : Google Scholar

5 

Yang P, Wang Y, Peng X, You G, Zhang W, Yan W, Bao Z, Wang Y, Qiu X and Jiang T: Management and survival rates in patients with glioma in China (2004-2010): A retrospective study from a single-institution. J Neurooncol. 113:259–266. 2013.PubMed/NCBI View Article : Google Scholar

6 

Delgado-López PD and Corrales-García EM: Survival in glioblastoma: A review on the impact of treatment modalities. Clin Transl Oncol. 18:1062–1071. 2016.PubMed/NCBI View Article : Google Scholar

7 

Omuro A and DeAngelis LM: Glioblastoma and other malignant gliomas: A clinical review. JAMA. 310:1842–1850. 2013.PubMed/NCBI View Article : Google Scholar

8 

Lohr J, Ratliff T, Huppertz A, Ge Y, Dictus C, Ahmadi R, Grau S, Hiraoka N, Eckstein V, Ecker RC, et al: Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived TGF-β. Clin Cancer Res. 17:4296–4308. 2011.PubMed/NCBI View Article : Google Scholar

9 

Murat A, Migliavacca E, Gorlia T, Lambiv WL, Shay T, Hamou MF, de Tribolet N, Regli L, Wick W, Kouwenhoven MC, et al: Stem cell-related ‘self-renewal’ signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol. 26:3015–3024. 2008.PubMed/NCBI View Article : Google Scholar

10 

Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, et al: Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression. Stem Cells. 32:1746–1758. 2014.PubMed/NCBI View Article : Google Scholar

11 

Pollner R, Schmidt C, Fischer G, Kühn K and Pöschl E: Cooperative and competitive interactions of regulatory elements are involved in the control of divergent transcription of human Col4A1 and Col4A2 genes. FEBS Lett. 405:31–36. 1997.PubMed/NCBI View Article : Google Scholar

12 

Yurchenco PD: Basement membranes: Cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol. 3(a004911)2011.PubMed/NCBI View Article : Google Scholar

13 

Labelle-Dumais C, Schuitema V, Hayashi G, Hoff K, Gong W, Dao DQ, Ullian EM, Oishi P, Margeta M and Gould DB: COL4A1 mutations cause neuromuscular disease with tissue-specific mechanistic heterogeneity. Am J Hum Genet. 104:847–860. 2019.PubMed/NCBI View Article : Google Scholar

14 

Jin R, Shen J, Zhang T, Liu Q, Liao C, Ma H, Li S and Yu Z: The highly expressed COL4A1 genes contributes to the proliferation and migration of the invasive ductal carcinomas. Oncotarget. 8:58172–58183. 2017.PubMed/NCBI View Article : Google Scholar

15 

Kitzler TM, Schneider R, Kohl S, Kolvenbach CM, Connaughton DM, Dai R, Mann N, Nakayama M, Majmundar AJ, Wu CW, et al: COL4A1 mutations as a potential novel cause of autosomal dominant CAKUT in humans. Hum Genet. 138:1105–1115. 2019.PubMed/NCBI View Article : Google Scholar

16 

Li F, Wang NN, Chang X, Wang SL, Wang LS, Yao J, Li ZS and Bai Y: Bioinformatics analysis suggests that COL4A1 may play an important role in gastric carcinoma recurrence. J Dig Dis. 20:391–400. 2019.PubMed/NCBI View Article : Google Scholar

17 

Lin S, Xia C, He S, Yang J, Li H, Zheng J, Liu M and You C: Genetic variations of the COL4A1 gene and intracerebral hemorrhage risk: A case-control study in a Chinese han population. World Neurosurg. 112:e527–e533. 2018.PubMed/NCBI View Article : Google Scholar

18 

Raza ST, Abbas S, Eba A, Karim F, Wani IA, Rizvi S, Zaidi A and Mahdi F: Association of COL4A1 (rs605143, rs565470) and CD14 (rs2569190) genes polymorphism with coronary artery disease. Mol Cell Biochem. 445:117–122. 2018.PubMed/NCBI View Article : Google Scholar

19 

Saskin A, Sillon G, Palfreeman N and Buhas D: COL4A1/2 CNVs and cerebral small vessel disease: Narrowing in on the critical chromosomal region. Neurology. 90:1026–1028. 2018.PubMed/NCBI View Article : Google Scholar

20 

Chen FF, Zhang SR, Peng H, Chen YZ and Cui XB: Integrative genomics analysis of hub genes and their relationship with prognosis and signaling pathways in esophageal squamous cell carcinoma. Mol Med Rep. 20:3649–3660. 2019.PubMed/NCBI View Article : Google Scholar

21 

Pan Z, Li L, Fang Q, Zhang Y, Hu X, Qian Y and Huang P: Analysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression. Cancer Cell Int. 18(214)2018.PubMed/NCBI View Article : Google Scholar

22 

Subramanian A, Kuehn H, Gould J, Tamayo P and Mesirov JP: GSEA-P: A desktop application for gene set enrichment analysis. Bioinformatics. 23:3251–3253. 2007.PubMed/NCBI View Article : Google Scholar

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) methods. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

24 

Wang SM, Chen PM, Sung YW, Huang WC, Huang HS and Chu PY: Effect of COL4A1 expression on the survival of neoadjuvant chemotherapy breast cancer patients. J Oncol. 2020(5209695)2020.PubMed/NCBI View Article : Google Scholar

25 

Wang T, Jin H, Hu J, Li X, Ruan H, Xu H, Wei L, Dong W, Teng F, Gu J, et al: COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling. J Exp Clin Cancer Res. 39(148)2020.PubMed/NCBI View Article : Google Scholar

26 

Wu F, Li F, Lin X, Xu F, Cui RR, Zhong JY, Zhu T, Shan SK, Liao XB, Yuan LQ and Mo ZH: Exosomes increased angiogenesis in papillary thyroid cancer microenvironment. Endocr Relat Cancer. 26:525–538. 2019.PubMed/NCBI View Article : Google Scholar

27 

Jiang Y, He J, Guo Y, Tao H, Pu F and Li Y: Identification of genes related to low-grade glioma progression and prognosis based on integrated transcriptome analysis. J Cell Biochem. 121:3099–3111. 2020.PubMed/NCBI View Article : Google Scholar

28 

Miyake M, Morizawa Y, Hori S, Tatsumi Y, Onishi S, Owari T, Iida K, Onishi K, Gotoh D, Nakai Y, et al: Diagnostic and prognostic role of urinary collagens in primary human bladder cancer. Cancer Sci. 108:2221–2228. 2017.PubMed/NCBI View Article : Google Scholar

29 

Aboubakar Nana F, Vanderputten M and Ocak S: Role of focal adhesion kinase in small-cell lung cancer and its potential as a therapeutic target. Cancers (Basel). 11(1683)2019.PubMed/NCBI View Article : Google Scholar

30 

Giaginis CT, Vgenopoulou S, Tsourouflis GS, Politi EN, Kouraklis GP and Theocharis SE: Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma. Pathol Oncol Res. 15:173–181. 2009.PubMed/NCBI View Article : Google Scholar

31 

Ozkal S, Paterson JC, Tedoldi S, Hansmann ML, Kargi A, Manek S, Mason DY and Marafioti T: Focal adhesion kinase (FAK) expression in normal and neoplastic lymphoid tissues. Pathol Res Pract. 205:781–788. 2009.PubMed/NCBI View Article : Google Scholar

32 

Ding L, Sun X, You Y, Liu N and Fu Z: Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival. Transl Res. 156:45–52. 2010.PubMed/NCBI View Article : Google Scholar

33 

Chen Z, Morales JE, Guerrero PA, Sun H and McCarty JH: PTPN12/PTP-PEST regulates phosphorylation-dependent ubiquitination and stability of focal adhesion substrates in invasive glioblastoma cells. Cancer Res. 78:3809–3822. 2018.PubMed/NCBI View Article : Google Scholar

34 

Haskell H, Natarajan M, Hecker TP, Ding Q, Stewart J Jr, Grammer JR and Gladson CL: Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells. Clin Cancer Res. 9:2157–2165. 2003.PubMed/NCBI

35 

Ferrer VP, Moura Neto V and Mentlein R: Glioma infiltration and extracellular matrix: Key players and modulators. Glia. 66:1542–1565. 2018.PubMed/NCBI View Article : Google Scholar

36 

Henrik Heiland D, Ravi VM, Behringer SP, Frenking JH, Wurm J, Joseph K, Garrelfs NWC, Strähle J, Heynckes S, Grauvogel J, et al: Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma. Nat Commun. 10(2541)2019.PubMed/NCBI View Article : Google Scholar

37 

Wang P, Peng X, Zhang J, Wang Z, Meng J, Cen B, Ji A and He S: LncRNA-135528 inhibits tumor progression by up-regulating CXCL10 through the JAK/STAT pathway. Apoptosis. 23:651–666. 2018.PubMed/NCBI View Article : Google Scholar

38 

Xu CH, Liu Y, Xiao LM, Chen LK, Zheng SY, Zeng EM, Li DH and Li YP: Silencing microRNA-221/222 cluster suppresses glioblastoma angiogenesis by suppressor of cytokine signaling-3-dependent JAK/STAT pathway. J Cell Physiol. 234:22272–22284. 2019.PubMed/NCBI View Article : Google Scholar

39 

Zhang P, Chen FZ, Jia QB and Hu DF: Upregulation of microRNA-133a and downregulation of connective tissue growth factor suppress cell proliferation, migration, and invasion in human glioma through the JAK/STAT signaling pathway. IUBMB Life. 71:1857–1875. 2019.PubMed/NCBI View Article : Google Scholar

40 

Hu F, Dzaye O, Hahn A, Yu Y, Scavetta RJ, Dittmar G, Kaczmarek AK, Dunning KR, Ricciardelli C, Rinnenthal JL, et al: Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling. Neuro Oncol. 17:200–210. 2015.PubMed/NCBI View Article : Google Scholar

41 

Wei L, Yi Z, Guo K and Long X: Long noncoding RNA BCAR4 promotes glioma cell proliferation via EGFR/PI3K/AKT signaling pathway. J Cell Physiol. 234:23608–23617. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang H, Liu Z, Li A, Wang J, Liu J, Liu B, Lian X, Zhang B, Pang B, Liu L, Liu L, et al: COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma. Exp Ther Med 22: 1224, 2021.
APA
Wang, H., Liu, Z., Li, A., Wang, J., Liu, J., Liu, B. ... Gao, Y. (2021). COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma. Experimental and Therapeutic Medicine, 22, 1224. https://doi.org/10.3892/etm.2021.10658
MLA
Wang, H., Liu, Z., Li, A., Wang, J., Liu, J., Liu, B., Lian, X., Zhang, B., Pang, B., Liu, L., Gao, Y."COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma". Experimental and Therapeutic Medicine 22.5 (2021): 1224.
Chicago
Wang, H., Liu, Z., Li, A., Wang, J., Liu, J., Liu, B., Lian, X., Zhang, B., Pang, B., Liu, L., Gao, Y."COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1224. https://doi.org/10.3892/etm.2021.10658
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Liu Z, Li A, Wang J, Liu J, Liu B, Lian X, Zhang B, Pang B, Liu L, Liu L, et al: COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma. Exp Ther Med 22: 1224, 2021.
APA
Wang, H., Liu, Z., Li, A., Wang, J., Liu, J., Liu, B. ... Gao, Y. (2021). COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma. Experimental and Therapeutic Medicine, 22, 1224. https://doi.org/10.3892/etm.2021.10658
MLA
Wang, H., Liu, Z., Li, A., Wang, J., Liu, J., Liu, B., Lian, X., Zhang, B., Pang, B., Liu, L., Gao, Y."COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma". Experimental and Therapeutic Medicine 22.5 (2021): 1224.
Chicago
Wang, H., Liu, Z., Li, A., Wang, J., Liu, J., Liu, B., Lian, X., Zhang, B., Pang, B., Liu, L., Gao, Y."COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1224. https://doi.org/10.3892/etm.2021.10658
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team