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Article Open Access

Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI

  • Authors:
    • Peiliang Li
    • Dainan Zhang
    • Shunchang Ma
    • Peng Kang
    • Chuanbao  Zhang
    • Beibei Mao
    • Wenjianlong Zhou
    • Xi Wang
    • Jiayi  Peng
    • Linhao  Yuan
    • Yangyang Wang
    • Jinfu Diao
    • Wang Jia
  • View Affiliations / Copyright

    Affiliations: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1255
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    Published online on: September 3, 2021
       https://doi.org/10.3892/etm.2021.10690
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Abstract

Pituitary adenomas, the most common type of lesion in the sellar region, rank third among all brain tumors, with an incidence of 73‑94 cases per 100,000 individuals. Due to its high resolution, MRI is highly efficient in brain imaging and has emerged as the most appropriate method for tumor consistency evaluation. The present study aimed to assess the levels of collagen types I and III in pituitary adenomas with different consistencies and to determine the value of T2‑weighted imaging (T2WI) MRI for predicting tumor consistency. A total of 55 patients with pituitary adenomas were divided into the soft and firm tumor groups according to intraoperative tumor consistency. The ratio of the tumor to Pons' signal intensities on T2WI scans was determined. A receiver operating characteristic curve was plotted to assess the specificity and sensitivity of T2WI in predicting tumor consistency. Average optical density (AOD) values for collagen types I (0.046±0.008 vs. 0.052±0.012, P=0.033) and III (0.044±0.008 vs. 0.050±0.010, P=0.016) were significantly lower in the soft tumor group compared with those in the firm tumor group. There was no significant difference in the ratio of the tumor to Pons' signal intensities on T2WI scans. The area under the ROC curve was 0.595±0.078 (P=0.250). The maximum tumor diameter significantly differed between the soft and firm tumor groups (P=0.001). AOD values for collagen types I and III were significantly correlated with the maximum tumor diameter (P<0.001). The amounts of collagen types I and III were elevated in firm pituitary tumors compared with the soft ones. The ratio of tumor to Pons' signal intensities on T2WI scans was not able to accurately predict tumor consistency. The size of pituitary adenomas may be associated with the expression levels of collagen types I and III.
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Copy and paste a formatted citation
Spandidos Publications style
Li P, Zhang D, Ma S, Kang P, Zhang C, Mao B, Zhou W, Wang X, Peng J, Yuan L, Yuan L, et al: Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI. Exp Ther Med 22: 1255, 2021.
APA
Li, P., Zhang, D., Ma, S., Kang, P., Zhang, C., Mao, B. ... Jia, W. (2021). Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI. Experimental and Therapeutic Medicine, 22, 1255. https://doi.org/10.3892/etm.2021.10690
MLA
Li, P., Zhang, D., Ma, S., Kang, P., Zhang, C., Mao, B., Zhou, W., Wang, X., Peng, J., Yuan, L., Wang, Y., Diao, J., Jia, W."Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI". Experimental and Therapeutic Medicine 22.5 (2021): 1255.
Chicago
Li, P., Zhang, D., Ma, S., Kang, P., Zhang, C., Mao, B., Zhou, W., Wang, X., Peng, J., Yuan, L., Wang, Y., Diao, J., Jia, W."Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1255. https://doi.org/10.3892/etm.2021.10690
Copy and paste a formatted citation
x
Spandidos Publications style
Li P, Zhang D, Ma S, Kang P, Zhang C, Mao B, Zhou W, Wang X, Peng J, Yuan L, Yuan L, et al: Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI. Exp Ther Med 22: 1255, 2021.
APA
Li, P., Zhang, D., Ma, S., Kang, P., Zhang, C., Mao, B. ... Jia, W. (2021). Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI. Experimental and Therapeutic Medicine, 22, 1255. https://doi.org/10.3892/etm.2021.10690
MLA
Li, P., Zhang, D., Ma, S., Kang, P., Zhang, C., Mao, B., Zhou, W., Wang, X., Peng, J., Yuan, L., Wang, Y., Diao, J., Jia, W."Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI". Experimental and Therapeutic Medicine 22.5 (2021): 1255.
Chicago
Li, P., Zhang, D., Ma, S., Kang, P., Zhang, C., Mao, B., Zhou, W., Wang, X., Peng, J., Yuan, L., Wang, Y., Diao, J., Jia, W."Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1255. https://doi.org/10.3892/etm.2021.10690
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