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Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study

  • Authors:
    • Teng Lu
    • Zhongyang Gao
    • Jialiang Li
    • Ning Liu
    • Yibin Wang
    • Chao Liu
    • Xijing He
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Spine Surgery, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, P.R. China, Department of Education, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1256
    |
    Published online on: September 3, 2021
       https://doi.org/10.3892/etm.2021.10691
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Abstract

Mismatch between the titanium mesh cage and cervical geometries is an important factor that induces subsidence in anterior cervical corpectomy and fusion (ACCF). The aim of the present study was to construct a new quadrate anatomically adaptive titanium mesh cage (AA‑TMC) that matches well with the cervical geometries and segmental alignment in one‑ and two‑level ACCF. Computed tomography (CT) scans of 54 individuals were used to measure the cervical endplate geometries. X‑rays of 74 young individuals were used to measure the intervertebral body angle (IBA) and intervertebral body height (IBH) of the surgical segments. The AA‑TMC was designed based on these measured parameters. A total of 18 cervical cadaveric specimens underwent successive one‑ and two‑level ACCF using the AA‑TMC. Postoperatively, the specimens underwent CT scanning to assess the degree of matching of the TMC‑endplate interface (TEI), IBA and IBH. A TEI interval <0.5 mm was considered well matching. In the sagittal plane, 93.8% of the inferior endplates were arched, whereas 94.8% of the superior endplates were flat. In the coronal plane, 82.9% of the inferior endplates and 93.8% of the superior endplates were flat. A total of 91.7 and 94.4% of the TEIs were well matched in one‑ and two‑level ACCF, respectively. The postoperative IBA and IBH values were consistent with the values of young individuals. The AA‑TMC achieved good matching with cervical geometries and segmental alignment in one‑ and two‑level ACCF, and is proposed for use in ACCF to increase the contact at the TEI and achieve sufficient lordosis restoration.
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1 

Zeng J, Duan Y, Yang Y, Wang B, Hong Y, Lou J, Ning N and Liu H: Anterior corpectomy and reconstruction using dynamic cervical plate and titanium mesh cage for cervical spondylotic myelopathy: A minimum 5-year follow-up study. Medicine (Baltimore). 97(e9724)2018.PubMed/NCBI View Article : Google Scholar

2 

Fengbin Y, Jinhao M, Xinyuan L, Xinwei W, Yu C and Deyu C: Evaluation of a new type of titanium mesh cage versus the traditional titanium mesh cage for single-level, anterior cervical corpectomy and fusion. Eur Spine J. 22:2891–2896. 2013.PubMed/NCBI View Article : Google Scholar

3 

Yan D, Wang Z, Deng S, Li J and Soo C: Anterior corpectomy and reconstruction with titanium mesh cage and dynamic cervical plate for cervical spondylotic myelopathy in elderly osteoporosis patients. Arch Orthop Trauma Surg. 131:1369–1374. 2011.PubMed/NCBI View Article : Google Scholar

4 

Wu J, Luo D, Ye X, Luo X, Yan L and Qian H: Anatomy-related risk factors for the subsidence of titanium mesh cage in cervical reconstruction after one-level corpectomy. Int J Clin Exp Med. 8:7405–7411. 2015.PubMed/NCBI

5 

Weber MH, Fortin M, Shen J, Tay B, Hu SS, Berven S, Burch S, Chou D, Ames C and Deviren V: Graft subsidence and revision rates following anterior cervical corpectomy: A clinical study comparing different interbody cages. Clin Spine Surg. 30:E1239–E1245. 2017.PubMed/NCBI View Article : Google Scholar

6 

Jang JW, Lee JK, Lee JH, Hur H, Kim TW and Kim SH: Effect of posterior subsidence on cervical alignment after anterior cervical corpectomy and reconstruction using titanium mesh cages in degenerative cervical disease. J Clin Neurosci. 21:1779–1785. 2014.PubMed/NCBI View Article : Google Scholar

7 

Chen Y, Chen D, Guo Y, Wang X, Lu X, He Z and Yuan W: Subsidence of titanium mesh cage: A study based on 300 cases. J Spinal Disord Tech. 21:489–492. 2008.PubMed/NCBI View Article : Google Scholar

8 

Hartmann S, Kavakebi P, Wipplinger C, Tschugg A, Girod PP, Lener S and Thomé C: Retrospective analysis of cervical corpectomies: Implant-related complications of one- and two-level corpectomies in 45 patients. Neurosurg Rev. 41:285–290. 2018.PubMed/NCBI View Article : Google Scholar

9 

Lu T, Liu C, Yang B, Liu J, Zhang F, Wang D, Li H and He X: Single-level anterior cervical corpectomy and fusion using a new 3D-printed anatomy-adaptive titanium mesh cage for treatment of cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament: A retrospective case series study. Med Sci Monit. 23:3105–3114. 2017.PubMed/NCBI View Article : Google Scholar

10 

Lou J, Liu H, Rong X, Li H, Wang B and Gong Q: Geometry of inferior endplates of the cervical spine. Clin Neurol Neurosurg. 142:132–136. 2016.PubMed/NCBI View Article : Google Scholar

11 

Ordway NR, Rim BC, Tan R, Hickman R and Fayyazi AH: Anterior cervical interbody constructs: Effect of a repetitive compressive force on the endplate. J Orthop Res. 30:587–592. 2012.PubMed/NCBI View Article : Google Scholar

12 

Lowe TG, Hashim S, Wilson LA, O'Brien MF, Smith DA, Diekmann MJ and Trommeter J: A biomechanical study of regional endplate strength and cage morphology as it relates to structural interbody support. Spine (Phila Pa 1976). 29:2389–2394. 2004.PubMed/NCBI View Article : Google Scholar

13 

Hasegawa K, Abe M, Washio T and Hara T: An experimental study on the interface strength between titanium mesh cage and vertebra in reference to vertebral bone mineral density. Spine (Phila Pa 1976). 26:957–963. 2001.PubMed/NCBI View Article : Google Scholar

14 

Brenke C, Fischer S, Carolus A, Schmieder K and Ening G: Complications associated with cervical vertebral body replacement with expandable titanium cages. J Clin Neurosci. 32:35–40. 2016.PubMed/NCBI View Article : Google Scholar

15 

Tarantino R, Nigro L, Donnarumma P, Rullo M, Santoro A and Delfini R: Cervical reconstruction techniques. After adequate selection of the patient report of a series of 34 patients treated with winged expandable cages. Neurosurg Rev. 40:281–286. 2017.PubMed/NCBI View Article : Google Scholar

16 

Chen H, Zhong J, Tan J, Wu D and Jiang D: Sagittal geometry of the middle and lower cervical endplates. Eur Spine J. 22:1570–1575. 2013.PubMed/NCBI View Article : Google Scholar

17 

Ordway NR, Lu YM, Zhang X, Cheng CC, Fang H and Fayyazi AH: Correlation of cervical endplate strength with CT measured subchondral bone density. Eur Spine J. 16:2104–2109. 2007.PubMed/NCBI View Article : Google Scholar

18 

Lu T, Liang H, Liu C, Guo S, Zhang T, Yang B and He X: Effects of titanium mesh cage end structures on the compressive load at the endplate interface: A cadaveric biomechanical study. Med Sci Monit. 23:2863–2870. 2017.PubMed/NCBI View Article : Google Scholar

19 

Feng H, Fang X, Huang D, Yu C, Zhao S and Hao D: Quantitative morphometric study of the subaxial cervical vertebrae end plate. Spine J. 17:269–276. 2017.PubMed/NCBI View Article : Google Scholar

20 

Feng H, Fang XY, Huang DG, Yu CC, Li HK, Zhao SC, Ge CY, Bai RH and Hao DJ: A morphometric study of the middle and lower cervical vertebral endplates and their components. Medicine (Baltimore). 96(e6296)2017.PubMed/NCBI View Article : Google Scholar

21 

Zhao S, Hao D, Jiang Y, Huang D, Ge C and Feng H: Morphological studies of cartilage endplates in subaxial cervical region. Eur Spine J. 25:2218–2222. 2016.PubMed/NCBI View Article : Google Scholar

22 

Schmitz B, Pitzen T, Beuter T, Steudel WI and Reith W: Regional variations in the thickness of cervical spine endplates as measured by computed tomography. Acta Radiol. 45:53–58. 2004.PubMed/NCBI View Article : Google Scholar

23 

Pitzen T, Schmitz B, Georg T, Barbier D, Beuter T, Steudel WI and Reith W: Variation of endplate thickness in the cervical spine. Eur Spine J. 13:235–240. 2004.PubMed/NCBI View Article : Google Scholar

24 

Cheng CC, Ordway NR, Zhang X, Lu YM, Fang H and Fayyazi AH: Loss of cervical endplate integrity following minimal surface preparation. Spine (Phila Pa 1976). 32:1852–1855. 2007.PubMed/NCBI View Article : Google Scholar

25 

van der Houwen EB, Baron P, Veldhuizen AG, Burgerhof JG, van Ooijen PM and Verkerke GJ: Geometry of the intervertebral volume and vertebral endplates of the human spine. Ann Biomed Eng. 38:33–40. 2010.PubMed/NCBI View Article : Google Scholar

26 

Steffen T, Tsantrizos A and Aebi M: Effect of implant design and endplate preparation on the compressive strength of interbody fusion constructs. Spine (Phila Pa 1976). 25:1077–1084. 2000.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lu T, Gao Z, Li J, Liu N, Wang Y, Liu C and He X: Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study. Exp Ther Med 22: 1256, 2021.
APA
Lu, T., Gao, Z., Li, J., Liu, N., Wang, Y., Liu, C., & He, X. (2021). Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study. Experimental and Therapeutic Medicine, 22, 1256. https://doi.org/10.3892/etm.2021.10691
MLA
Lu, T., Gao, Z., Li, J., Liu, N., Wang, Y., Liu, C., He, X."Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study". Experimental and Therapeutic Medicine 22.5 (2021): 1256.
Chicago
Lu, T., Gao, Z., Li, J., Liu, N., Wang, Y., Liu, C., He, X."Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1256. https://doi.org/10.3892/etm.2021.10691
Copy and paste a formatted citation
x
Spandidos Publications style
Lu T, Gao Z, Li J, Liu N, Wang Y, Liu C and He X: Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study. Exp Ther Med 22: 1256, 2021.
APA
Lu, T., Gao, Z., Li, J., Liu, N., Wang, Y., Liu, C., & He, X. (2021). Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study. Experimental and Therapeutic Medicine, 22, 1256. https://doi.org/10.3892/etm.2021.10691
MLA
Lu, T., Gao, Z., Li, J., Liu, N., Wang, Y., Liu, C., He, X."Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study". Experimental and Therapeutic Medicine 22.5 (2021): 1256.
Chicago
Lu, T., Gao, Z., Li, J., Liu, N., Wang, Y., Liu, C., He, X."Construction of a new cervical anatomically adaptive titanium mesh cage based on measurements of cervical geometry: A morphological and cadaveric study". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1256. https://doi.org/10.3892/etm.2021.10691
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