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Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review)

  • Authors:
    • Ariadna Petronela Fildan
    • Ruxandra-Mioara Rajnoveanu
    • Roxana Cirjaliu
    • Ionela Pohrib
    • Emanuela Tudorache
    • Adrian Cosmin Ilie
    • Cristian Oancea
    • Doina Tofolean
  • View Affiliations / Copyright

    Affiliations: Faculty of Medicine, Ovidius University, Constanța 900527, Romania, Department of Pneumology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj‑Napoca 400371, Romania, Department of Pneumology, Victor Babes University of Medicine and Pharmacy, Timisoara 300041, Romania
    Copyright: © Fildan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1263
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    Published online on: September 6, 2021
       https://doi.org/10.3892/etm.2021.10698
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Abstract

Asthma is a variable chronic respiratory disease characterized by airway inflammation and hyperresponsiveness, bronchoconstriction, and mucus hypersecretion. While most patients with asthma achieve good control of the disease, 5‑10% experience severe symptoms and recurrent exacerbation despite the maximal offered therapy with inhaled corticosteroids and long acting bronchodilators. In previous years, novel biological therapies have become available, and various asthma phenotypes that are characterized by specific biomarkers have been identified. Currently approved biological agents target inflammatory molecules of the type 2 inflammatory pathway, and are effective at decreasing the frequency of asthma attacks, controlling symptoms and decreasing use of systemic steroids. The present study reviewed the effectiveness and safety profile of the currently approved biological drugs and provided an overview of the assessment of patients with severe asthma who are potentially suitable for biological therapy, in order to help clinicians to select the most appropriate biological agent.
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Copy and paste a formatted citation
Spandidos Publications style
Fildan AP, Rajnoveanu R, Cirjaliu R, Pohrib I, Tudorache E, Ilie AC, Oancea C and Tofolean D: Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review). Exp Ther Med 22: 1263, 2021.
APA
Fildan, A.P., Rajnoveanu, R., Cirjaliu, R., Pohrib, I., Tudorache, E., Ilie, A.C. ... Tofolean, D. (2021). Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review). Experimental and Therapeutic Medicine, 22, 1263. https://doi.org/10.3892/etm.2021.10698
MLA
Fildan, A. P., Rajnoveanu, R., Cirjaliu, R., Pohrib, I., Tudorache, E., Ilie, A. C., Oancea, C., Tofolean, D."Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1263.
Chicago
Fildan, A. P., Rajnoveanu, R., Cirjaliu, R., Pohrib, I., Tudorache, E., Ilie, A. C., Oancea, C., Tofolean, D."Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1263. https://doi.org/10.3892/etm.2021.10698
Copy and paste a formatted citation
x
Spandidos Publications style
Fildan AP, Rajnoveanu R, Cirjaliu R, Pohrib I, Tudorache E, Ilie AC, Oancea C and Tofolean D: Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review). Exp Ther Med 22: 1263, 2021.
APA
Fildan, A.P., Rajnoveanu, R., Cirjaliu, R., Pohrib, I., Tudorache, E., Ilie, A.C. ... Tofolean, D. (2021). Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review). Experimental and Therapeutic Medicine, 22, 1263. https://doi.org/10.3892/etm.2021.10698
MLA
Fildan, A. P., Rajnoveanu, R., Cirjaliu, R., Pohrib, I., Tudorache, E., Ilie, A. C., Oancea, C., Tofolean, D."Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1263.
Chicago
Fildan, A. P., Rajnoveanu, R., Cirjaliu, R., Pohrib, I., Tudorache, E., Ilie, A. C., Oancea, C., Tofolean, D."Biological therapies targeting the type 2 inflammatory pathway in severe asthma (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1263. https://doi.org/10.3892/etm.2021.10698
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