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Review Open Access

Association between obesity and iron deficiency (Review)

  • Authors:
    • Naseem Mohammad Alshwaiyat
    • Aryati Ahmad
    • Wan Mohd Razin Wan Hassan
    • Hamid Ali Nagi Al‑Jamal
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    Affiliations: School of Nutrition and Dietetics, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, Kuala Terengganu, Terengganu 21300, Malaysia, Faculty of Medicine, Universiti Sultan Zainal Abidin, Medical Campus, Kuala Terengganu, Terengganu 20400, Malaysia, School of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, Kuala Terengganu, Terengganu 21300, Malaysia
    Copyright: © Alshwaiyat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1268
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    Published online on: September 7, 2021
       https://doi.org/10.3892/etm.2021.10703
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Abstract

Obesity is a risk factor for several comorbidities and complications, including iron deficiency anemia. Iron deficiency anemia is a serious global public health problem, with a worldwide prevalence. The high prevalence of obesity in combination with iron deficiency incidence observed in different age and sex categories suggests an association between obesity and iron status. Obesity may disrupt iron homeostasis, resulting in iron deficiency anemia. The association between obesity and iron deficiency may be due to increased hepcidin levels mediated by chronic inflammation. Hepcidin is a small peptide hormone that functions as a negative regulator of intestinal iron absorption. Significant body weight loss in overweight and obese individuals decreases chronic inflammation and serum hepcidin levels, resulting in improved iron status due to increased iron absorption. However, further randomized controlled trials are required to confirm this effect.
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Copy and paste a formatted citation
Spandidos Publications style
Alshwaiyat NM, Ahmad A, Wan Hassan W and Al‑Jamal HA: Association between obesity and iron deficiency (Review). Exp Ther Med 22: 1268, 2021.
APA
Alshwaiyat, N.M., Ahmad, A., Wan Hassan, W., & Al‑Jamal, H.A. (2021). Association between obesity and iron deficiency (Review). Experimental and Therapeutic Medicine, 22, 1268. https://doi.org/10.3892/etm.2021.10703
MLA
Alshwaiyat, N. M., Ahmad, A., Wan Hassan, W., Al‑Jamal, H. A."Association between obesity and iron deficiency (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1268.
Chicago
Alshwaiyat, N. M., Ahmad, A., Wan Hassan, W., Al‑Jamal, H. A."Association between obesity and iron deficiency (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1268. https://doi.org/10.3892/etm.2021.10703
Copy and paste a formatted citation
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Spandidos Publications style
Alshwaiyat NM, Ahmad A, Wan Hassan W and Al‑Jamal HA: Association between obesity and iron deficiency (Review). Exp Ther Med 22: 1268, 2021.
APA
Alshwaiyat, N.M., Ahmad, A., Wan Hassan, W., & Al‑Jamal, H.A. (2021). Association between obesity and iron deficiency (Review). Experimental and Therapeutic Medicine, 22, 1268. https://doi.org/10.3892/etm.2021.10703
MLA
Alshwaiyat, N. M., Ahmad, A., Wan Hassan, W., Al‑Jamal, H. A."Association between obesity and iron deficiency (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1268.
Chicago
Alshwaiyat, N. M., Ahmad, A., Wan Hassan, W., Al‑Jamal, H. A."Association between obesity and iron deficiency (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1268. https://doi.org/10.3892/etm.2021.10703
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