Open Access

Association between obesity and iron deficiency (Review)

  • Authors:
    • Naseem Mohammad Alshwaiyat
    • Aryati Ahmad
    • Wan Mohd Razin Wan Hassan
    • Hamid Ali Nagi Al‑Jamal
  • View Affiliations

  • Published online on: September 7, 2021     https://doi.org/10.3892/etm.2021.10703
  • Article Number: 1268
  • Copyright: © Alshwaiyat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Obesity is a risk factor for several comorbidities and complications, including iron deficiency anemia. Iron deficiency anemia is a serious global public health problem, with a worldwide prevalence. The high prevalence of obesity in combination with iron deficiency incidence observed in different age and sex categories suggests an association between obesity and iron status. Obesity may disrupt iron homeostasis, resulting in iron deficiency anemia. The association between obesity and iron deficiency may be due to increased hepcidin levels mediated by chronic inflammation. Hepcidin is a small peptide hormone that functions as a negative regulator of intestinal iron absorption. Significant body weight loss in overweight and obese individuals decreases chronic inflammation and serum hepcidin levels, resulting in improved iron status due to increased iron absorption. However, further randomized controlled trials are required to confirm this effect.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Alshwaiyat NM, Ahmad A, Wan Hassan W and Al‑Jamal HA: Association between obesity and iron deficiency (Review). Exp Ther Med 22: 1268, 2021
APA
Alshwaiyat, N.M., Ahmad, A., Wan Hassan, W., & Al‑Jamal, H.A. (2021). Association between obesity and iron deficiency (Review). Experimental and Therapeutic Medicine, 22, 1268. https://doi.org/10.3892/etm.2021.10703
MLA
Alshwaiyat, N. M., Ahmad, A., Wan Hassan, W., Al‑Jamal, H. A."Association between obesity and iron deficiency (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1268.
Chicago
Alshwaiyat, N. M., Ahmad, A., Wan Hassan, W., Al‑Jamal, H. A."Association between obesity and iron deficiency (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1268. https://doi.org/10.3892/etm.2021.10703