Open Access

Role of circular RNAs in osteoarthritis (Review)

  • Authors:
    • Jicheng Wang
    • Bo Yang
    • Changkun Wu
    • Yongzhi Guo
    • Xin Jiang
    • Yangyang Zhang
  • View Affiliations

  • Published online on: September 9, 2021     https://doi.org/10.3892/etm.2021.10714
  • Article Number: 1279
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation. OA is the most common form of arthritis, and the major clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect patients' quality of life. Circular RNA (circRNA) is a type of non‑coding RNA that is ubiquitous in eukaryotic cells. Unlike standard linear RNAs, they form a covalently closed continuous loop without 5' or 3' polarity. They are usually considered as byproducts of mis‑splicing or mRNA processing. CircRNAs have been detected and identified in numerous species. Various studies have confirmed that certain circRNAs are differentially expressed in OA cartilage and are closely associated with a variety of pathological processes of OA, including extracellular matrix degradation, inflammation and apoptosis. The present study reviewed the latest research on circRNAs in the pathogenesis of OA, providing a novel direction for the prevention, diagnosis and treatment of OA.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Yang B, Wu C, Guo Y, Jiang X and Zhang Y: Role of circular RNAs in osteoarthritis (Review). Exp Ther Med 22: 1279, 2021
APA
Wang, J., Yang, B., Wu, C., Guo, Y., Jiang, X., & Zhang, Y. (2021). Role of circular RNAs in osteoarthritis (Review). Experimental and Therapeutic Medicine, 22, 1279. https://doi.org/10.3892/etm.2021.10714
MLA
Wang, J., Yang, B., Wu, C., Guo, Y., Jiang, X., Zhang, Y."Role of circular RNAs in osteoarthritis (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1279.
Chicago
Wang, J., Yang, B., Wu, C., Guo, Y., Jiang, X., Zhang, Y."Role of circular RNAs in osteoarthritis (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1279. https://doi.org/10.3892/etm.2021.10714