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Article

Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression

  • Authors:
    • Feng Liu
    • Guodong Ma
    • Bo Wang
    • Xiang Wang
    • Chenjun Huang
  • View Affiliations / Copyright

    Affiliations: Department of Chest Surgery, Nanjing Chest Hospital, Nanjing, Jiangsu 210029, P.R. China, Department of Oncology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221000, P.R. China, Department of Thoracic Surgery, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China
  • Article Number: 1284
    |
    Published online on: September 13, 2021
       https://doi.org/10.3892/etm.2021.10719
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Abstract

Non‑small cell lung cancer (NSCLC) is one of the most important causes of cancer‑related death. miR‑1181 has been reported to have roles in various cancer types and its function in the progression of NSCLC was investigated in the present study. A total of 118 patients with NSCLC were recruited and their tumor tissues were collected. The expression of miR‑1181 in NSCLC tissues and cells was detected by reverse transcription‑quantitative PCR. The prognostic value of miR‑1181 was evaluated by Kaplan‑Meier and Cox regression analysis and the roles of miR‑1181 in cell proliferation, migration and invasion of NSCLC were analyzed by Cell Counting Kit‑8 and Transwell assays. miR‑1181 was indicated to be upregulated in NSCLC tissues and cell lines, and to be associated with lymph node metastasis and the TNM stage of patients. Patients with high miR‑1181 expression had a poorer prognosis than those with low miR‑1181 expression. miR‑1181 levels and TNM stage were determined to be two independent prognostic factors for NSCLC. In addition, overexpression of miR‑1181 exerted enhancing effects on cell proliferation, migration and invasion of NSCLC, while its knockdown inhibited these cellular processes. In conclusion, upregulation of miR‑1181 in NSCLC was associated with lymph node metastasis and TNM stage of patients and was indicative of poor prognosis. miR‑1181 was indicated to exert promoting effects on cell proliferation, migration and invasion of NSCLC cells and to be involved in tumor progression, providing novel insight for the development of biomarkers and therapies for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Ma G, Wang B, Wang X and Huang C: Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression. Exp Ther Med 22: 1284, 2021.
APA
Liu, F., Ma, G., Wang, B., Wang, X., & Huang, C. (2021). Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression. Experimental and Therapeutic Medicine, 22, 1284. https://doi.org/10.3892/etm.2021.10719
MLA
Liu, F., Ma, G., Wang, B., Wang, X., Huang, C."Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression". Experimental and Therapeutic Medicine 22.5 (2021): 1284.
Chicago
Liu, F., Ma, G., Wang, B., Wang, X., Huang, C."Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1284. https://doi.org/10.3892/etm.2021.10719
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Ma G, Wang B, Wang X and Huang C: Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression. Exp Ther Med 22: 1284, 2021.
APA
Liu, F., Ma, G., Wang, B., Wang, X., & Huang, C. (2021). Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression. Experimental and Therapeutic Medicine, 22, 1284. https://doi.org/10.3892/etm.2021.10719
MLA
Liu, F., Ma, G., Wang, B., Wang, X., Huang, C."Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression". Experimental and Therapeutic Medicine 22.5 (2021): 1284.
Chicago
Liu, F., Ma, G., Wang, B., Wang, X., Huang, C."Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1284. https://doi.org/10.3892/etm.2021.10719
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