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Role of caveolin‑1 in chronic postsurgical pain in rats

  • Authors:
    • Sai-Sai Huang
    • Su Cao
    • Yi-Bin Qin
    • Cui E. Lu
    • Shi-Ren Shen
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    Affiliations: Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1289
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    Published online on: September 13, 2021
       https://doi.org/10.3892/etm.2021.10724
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Abstract

Chronic postsurgical pain (CPSP) has a high incidence, but the underlying mechanisms remain elusive. Previous studies have indicated that caveolin‑1 (Cav‑1) plays a notable role in pain modulation. To study the role of Cav‑1 in CPSP in the present study, a rat model of skin/muscle incision and retraction (SMIR) was established. Under anesthesia, skin and superficial muscle of the medial thigh were incised and a small pair of retractors inserted. It was revealed that SMIR increased the expression of Cav‑1 in the dorsal root ganglion (DRG) and the injured tissue around the incision. Furthermore, the infiltration of endothelial cells and macrophages in the injured tissue around the incision increased constantly, and the vascular permeability increased due to the destruction of the vascular endothelial barrier function around the injured tissue. Cav‑1 was mainly expressed by CD68‑positive macrophages and CD34‑positive endothelial cells in the injured tissues around the incision, while it was also primarily localized in the medium and large neurofilament 200‑positive neurons and a small number of calcitonin gene‑related peptide‑ and isolectin B4‑positive small and medium‑sized neurons in the DRG. The results demonstrated that the sustained high expression levels of Cav‑1 in the injured tissue around the incision could lead to the dysfunction of the vascular endothelial barrier and, thus, could induce the inflammatory response through the lipoprotein transport of endothelial cells, thereby resulting in peripheral sensitization. In addition, the sustained high expression levels of Cav‑1 in the DRG could sensitize large‑sized neurons and change the transmission mode of noxious stimuli. The findings of the present study indicated that a Cav‑1‑mediated process could participate in neuronal transmission pathways associated with pain modulation.
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Copy and paste a formatted citation
Spandidos Publications style
Huang S, Cao S, Qin Y, Lu CE and Shen S: Role of caveolin‑1 in chronic postsurgical pain in rats. Exp Ther Med 22: 1289, 2021.
APA
Huang, S., Cao, S., Qin, Y., Lu, C.E., & Shen, S. (2021). Role of caveolin‑1 in chronic postsurgical pain in rats. Experimental and Therapeutic Medicine, 22, 1289. https://doi.org/10.3892/etm.2021.10724
MLA
Huang, S., Cao, S., Qin, Y., Lu, C. E., Shen, S."Role of caveolin‑1 in chronic postsurgical pain in rats". Experimental and Therapeutic Medicine 22.5 (2021): 1289.
Chicago
Huang, S., Cao, S., Qin, Y., Lu, C. E., Shen, S."Role of caveolin‑1 in chronic postsurgical pain in rats". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1289. https://doi.org/10.3892/etm.2021.10724
Copy and paste a formatted citation
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Spandidos Publications style
Huang S, Cao S, Qin Y, Lu CE and Shen S: Role of caveolin‑1 in chronic postsurgical pain in rats. Exp Ther Med 22: 1289, 2021.
APA
Huang, S., Cao, S., Qin, Y., Lu, C.E., & Shen, S. (2021). Role of caveolin‑1 in chronic postsurgical pain in rats. Experimental and Therapeutic Medicine, 22, 1289. https://doi.org/10.3892/etm.2021.10724
MLA
Huang, S., Cao, S., Qin, Y., Lu, C. E., Shen, S."Role of caveolin‑1 in chronic postsurgical pain in rats". Experimental and Therapeutic Medicine 22.5 (2021): 1289.
Chicago
Huang, S., Cao, S., Qin, Y., Lu, C. E., Shen, S."Role of caveolin‑1 in chronic postsurgical pain in rats". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1289. https://doi.org/10.3892/etm.2021.10724
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