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Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer

  • Authors:
    • Yanfei Bai
    • Haitao Li
    • Rui Lv
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Lanzhou Second People's Hospital, Lanzhou, Gansu 730000, P.R. China, Department of Gynecology, Affiliated Hospital of Gansu Medical College, Lanzhou, Gansu 744000, P.R. China, Department of Gynecologic Oncology, Gansu Provincial Cancer Hospital, Lanzhou, Gansu 730030, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1291
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    Published online on: September 13, 2021
       https://doi.org/10.3892/etm.2021.10726
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Abstract

Interleukin (IL)‑17 has been regarded as a significant factor in inflammation. In addition, IL‑17 is known to be involved in the progression of cancers; however, the function of IL‑17 in cervical cancer remains unclear. In the present study, cell viability was detected by Cell Counting Kit‑8 assay. Quantitative PCR and western blotting were performed to detect gene and protein expression levels, respectively, in cancer cells or tissues. Ki‑67 staining was used to evaluate cell proliferation. Wound‑healing assay was used to detect cell migration. Moreover, Transwell assay was performed to investigate the invasion of cervical cancer cells. The results revealed that IL‑17 significantly promoted the proliferation of cervical cancer cells. Additionally, IL‑17 notably enhanced the migration and invasion of cervical cancer cells in vitro. IL‑17 promoted the progression of cervical cancer via the activation of JAK2/STAT3 and PI3K/Akt/NF‑κB signaling. In conclusion, IL‑17 was a key regulator during the progression of cervical cancer through the JAK2/STAT3 and PI3K/Akt/nuclear factor‑κB signaling pathway, which may serve as a novel target for the treatment of cervical cancer.
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1 

Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A and Galazios G: Cervical cancer: Screening, diagnosis and staging. J BUON. 21:320–325. 2016.PubMed/NCBI

2 

Benard VB, Thomas CC, King J, Massetti GM, Doria-Rose VP and Saraiya M: Centers for Disease C and Prevention (CDC). Vital signs: Cervical cancer incidence, mortality, and screening-United States, 2007-2012. MMWR Morb Mortal Wkly Rep. 63:1004–1009. 2014.PubMed/NCBI

3 

Zeng SY, Liang MR, Li LY, Li L, Jiang W and Zhong ML: Application of transvaginal external fascia trachelectomy in the treatment of CIN and micro-invasive cervical cancer. Zhonghua Zhong Liu Za Zhi. 35:543–546. 2013.PubMed/NCBI(In Chinese).

4 

Gilham C, Sargent A, Kitchener HC and Peto J: HPV testing compared with routine cytology in cervical screening: Long-term follow-up of ARTISTIC RCT. Health Technol Assess. 23:1–44. 2019.PubMed/NCBI View Article : Google Scholar

5 

Hong DK, Kim SA, Lim KT, Lee KH, Kim TJ and So KA: Clinical outcome of high-grade cervical intraepithelial neoplasia during pregnancy: A 10-year experience. Eur J Obstet Gynecol Reprod Biol. 236:173–176. 2019.PubMed/NCBI View Article : Google Scholar

6 

Cheng X, Feng Y, Wang X, Wan X, Xie X and Lu W: The effectiveness of conization treatment for post-menopausal women with high-grade cervical intraepithelial neoplasia. Exp Ther Med. 5:185–188. 2013.PubMed/NCBI View Article : Google Scholar

7 

Ostojic DV, Vrdoljak-Mozetic D, Stemberger-Papic S, Finderle A and Eminovic S: Cervical cytology and HPV test in follow-up after conisation or LLETZ. Coll Antropol. 34:219–224. 2010.PubMed/NCBI

8 

Apgar BS, Kittendorf AL, Bettcher CM, Wong J and Kaufman AJ: Update on ASCCP consensus guidelines for abnormal cervical screening tests and cervical histology. Am Fam Physician. 80:147–155. 2009.PubMed/NCBI

9 

Guo N, Shen G, Zhang Y, Moustafa AA, Ge D and You Z: Interleukin-17 promotes migration and invasion of human cancer cells through upregulation of MTA1 expression. Front Oncol. 9(546)2019.PubMed/NCBI View Article : Google Scholar

10 

Alves JJ, De Medeiros Fernandes TAA, De Araujo JM, Cobucci RN, Lanza DC, Bezerra FL, Andrade VS and Fernandes JV: Th17 response in patients with cervical cancer. Oncol Lett. 16:6215–6227. 2018.PubMed/NCBI View Article : Google Scholar

11 

Karabulut M, Usul Afsar C, Serimez M and Karabulut S: Serum IL-17 levels can be diagnostic for gastric cancer. J BUON. 24:1601–1609. 2019.PubMed/NCBI

12 

Iwakura Y, Ishigame H, Saijo S and Nakae S: Functional specialization of interleukin-17 family members. Immunity. 34:149–162. 2011.PubMed/NCBI View Article : Google Scholar

13 

Lotti F, Jarrar AM, Pai RK, Hitomi M, Lathia J, Mace A, Gantt GA Jr, Sukhdeo K, DeVecchio J, Vasanji A, et al: Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J Exp Med. 210:2851–2872. 2013.PubMed/NCBI View Article : Google Scholar

14 

Flies EJ, Mavoa S, Zosky GR, Mantzioris E, Williams C, Eri R, Brook BW and Buettel JC: Urban-associated diseases: Candidate diseases, environmental risk factors, and a path forward. Environ Int. 133(105187)2019.PubMed/NCBI View Article : Google Scholar

15 

Alshammari TK, Alghamdi H, Green TA, Niazy A, Alkahdar L, Alrasheed N, Alhosaini K, Alswayyed M, Elango R, Laezza F, et al: Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions. PLoS One. 14(e0222818)2019.PubMed/NCBI View Article : Google Scholar

16 

Nagarkoti S, Dubey M, Sadaf S, Awasthi D, Chandra T, Jagavelu K, Kumar S and Dikshit M: Catalase S-Glutathionylation by NOX2 and mitochondrial-derived ROS adversely affects mice and human neutrophil survival. Inflammation. 42:2286–2296. 2019.PubMed/NCBI View Article : Google Scholar

17 

Cong J, Liu R, Wang X, Sheng L, Jiang H, Wang W, Zhang Y, Yang S and Li C: Association between interluekin-17 gene polymorphisms and the risk of cervical cancer in a Chinese population. Int J Clin Exp Pathol. 8:9567–9573. 2015.PubMed/NCBI

18 

Miranda LN, Reginaldo FP, Souza DM, Soares CP, Silva TG, Rocha KB, Jatoba CA, Donadi EA, Andrade JM, Goncalves AK and Crispim JC: Greater expression of the human leukocyte antigen-G (HLA-G) and interleukin-17 (IL-17) in cervical intraepithelial neoplasia: Analytical cross-sectional study. Sao Paulo Med J. 133:336–342. 2015.PubMed/NCBI View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

20 

Song Y, Yang M, Zhang H, Sun Y, Tao Y, Li H, Zhang J, Li Y and Yang J: IL-17 affects the progression, metastasis, and recurrence of laryngeal cancer via the inhibition of apoptosis through activation of the PI3K/AKT/FAS/FASL pathways. J Immunol Res. 2020(2953191)2020.PubMed/NCBI View Article : Google Scholar

21 

Lu W, He F, Lin Z, Liu S, Tang L, Huang Y and Hu Z: Dysbiosis of the endometrial microbiota and its association with inflammatory cytokines in endometrial cancer. Int J Cancer. 148:1708–1716. 2021.PubMed/NCBI View Article : Google Scholar

22 

Liao C, Zhang C, Jin L and Yang Y: IL-17 alters the mesenchymal stem cell niche towards osteogenesis in cooperation with osteocytes. J Cell Physiol. 235:4466–4480. 2020.PubMed/NCBI View Article : Google Scholar

23 

Guo JQ, Liu J and Lu B: Expression of gamma-delta T cells in immune microenvironment in children with Henoch-Schonlein purpura. Zhongguo Dang Dai Er Ke Za Zhi. 21:960–965. 2019.PubMed/NCBI View Article : Google Scholar : (In Chinese).

24 

Siefker DT, Vu L, You D, McBride A, Taylor R, Jones TL, DeVincenzo J and Cormier SA: Respiratory syncytial virus disease severity is associated with distinct CD8+ T-cell profiles. Am J Respir Crit Care Med. 201:325–334. 2020.PubMed/NCBI View Article : Google Scholar

25 

Wang J, Lu L, Luo Z, Li W, Lu Y, Tang Q and Pu J: MiR-383 inhibits cell growth and promotes cell apoptosis in hepatocellular carcinoma by targeting IL-17 via STAT3 signaling pathway. Biomed Pharmacother. 120(109551)2019.PubMed/NCBI View Article : Google Scholar

26 

Zhang N, Wang Q, Tian Y, Xiong S, Li G and Xu L: Expressions of IL-17 and TNF-α in patients with Hashimoto's disease combined with thyroid cancer before and after surgery and their relationship with prognosis. Clin Transl Oncol. 22:1280–1287. 2020.PubMed/NCBI View Article : Google Scholar

27 

Kinoshita M, Kobayashi S, Gotoh K, Kubo M, Hayashi K, Iwagami Y, Yamada D, Akita H, Noda T, Asaoka T, et al: Heterogeneity of Treg/Th17 according to cancer progression and modification in biliary tract cancers via self-producing cytokines. Dig Dis Sci. 65:2937–2948. 2020.PubMed/NCBI View Article : Google Scholar

28 

Amara S, Majors C, Roy B, Hill S, Rose KL, Myles EL and Tiriveedhi V: Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation. PLoS One. 12(e0180097)2017.PubMed/NCBI View Article : Google Scholar

29 

Varikuti S, Oghumu S, Elbaz M, Volpedo G, Ahirwar DK, Alarcon PC, Sperling RH, Moretti E, Pioso MS, Kimble J, et al: STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade. Oncoimmunology. 6(e1361088)2017.PubMed/NCBI View Article : Google Scholar

30 

Zou Y, Dai SX, Chi HG, Li T, He ZW, Wang J, Ye CG, Huang GL, Zhao B, Li WY, et al: Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm. Arch Pharm Res. 38:1873–1887. 2015.PubMed/NCBI View Article : Google Scholar

31 

Song KH, Jung SY, Kang SM, Kim MH, Ahn J, Hwang SG, Lee JH, Lim DS, Nam SY and Song JY: Induction of immunogenic cell death by radiation-upregulated karyopherin alpha 2 in vitro. Eur J Cell Biol. 95:219–227. 2016.PubMed/NCBI View Article : Google Scholar

32 

Perez-Figueroa E, Sanchez-Cuaxospa M, Martinez-Soto KA, Sanchez-Zauco N, Medina-Sanson A, Jimenez-Hernandez E, Torres-Nava JR, Felix-Castro JM, Gomez A, Ortega E, et al: Strong inflammatory response and Th1-polarization profile in children with acute lymphoblastic leukemia without apparent infection. Oncol Rep. 35:2699–2706. 2016.PubMed/NCBI View Article : Google Scholar

33 

Souza CM, do Amaral CL, Souza SC, de Souza ACP, de Cassia Alves Martins I, Contieri LS, Milanski M, Torsoni AS, Ignacio-Souza LM and Torsoni MA: JAK2/STAT3 pathway is required for alpha7nAChR-dependent expression of POMC and AGRP neuropeptides in male mice. Cell Physiol Biochem. 53:701–712. 2019.PubMed/NCBI View Article : Google Scholar

34 

Fogg KC, Olson WR, Miller JN, Khan A, Renner C, Hale I, Weisman PS and Kreeger PK: Alternatively activated macrophage-derived secretome stimulates ovarian cancer spheroid spreading through a JAK2/STAT3 pathway. Cancer Lett. 458:92–101. 2019.PubMed/NCBI View Article : Google Scholar

35 

Wei L, Chen Y, Zhang C, Liu M and Xiong H: Leptin induces IL-6 and IL-8 expression through leptin receptor Ob-Rb in human dental pulp fibroblasts. Acta Odontol Scand. 77:205–212. 2019.PubMed/NCBI View Article : Google Scholar

36 

Song Q, Liu B, Li X, Zhang Q, Cao L, Xu M, Meng Z, Wu X and Xu K: MiR-26a-5p potentiates metastasis of human lung cancer cells by regulating ITGβ8-JAK2/STAT3 axis. Biochem Biophys Res Commun. 501:494–500. 2018.PubMed/NCBI View Article : Google Scholar

37 

Zhang L, Lu P, Guo X, Liu T, Luo X and Zhu YT: Inhibition of JAK2/STAT3 signaling pathway protects mice from the DDP-induced acute kidney injury in lung cancer. Inflamm Res. 68:751–760. 2019.PubMed/NCBI View Article : Google Scholar

38 

Wu D, Dong W, Fang K and Wang M: As4S4 exhibits good killing effect on multiple myeloma cells via repressing SOCS1 methylation-mediated JAK2/STAT3 signaling pathway. Technol Cancer Res Treat. 18(1533033819896806)2019.PubMed/NCBI View Article : Google Scholar

39 

Jing W, Guo X, Wang G, Bi Y, Han L, Zhu Q, Qiu C, Tanaka M and Zhao Y: Breast cancer cells promote CD169+ macrophage-associated immunosuppression through JAK2-mediated PD-L1 upregulation on macrophages. Int Immunopharmacol. 78(106012)2020.PubMed/NCBI View Article : Google Scholar

40 

Wang X, Yin H, Zhang L, Zheng D, Yang Y, Zhang J, Jiang H, Ling X, Xin Y, Liang H, et al: The construction and analysis of the aberrant lncRNA-miRNA-mRNA network in non-small cell lung cancer. J Thorac Dis. 11:1772–1778. 2019.PubMed/NCBI View Article : Google Scholar

41 

Li X, Mak VCY, Zhou Y, Wang C, Wong ESY, Sharma R, Lu Y, Cheung ANY, Mills GB and Cheung LWT: Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer. Nat Commun. 10(716)2019.PubMed/NCBI View Article : Google Scholar

42 

Deng F, Wang S, Zhang L, Xie X, Cai S, Li H, Xie GL, Miao HL, Yang C, Liu X and Xia Z: Propofol through upregulating caveolin-3 attenuates post-hypoxic mitochondrial damage and cell death in H9C2 cardiomyocytes during hyperglycemia. Cell Physiol Biochem. 44:279–292. 2017.PubMed/NCBI View Article : Google Scholar

43 

Li YL, Gao L, Zucker IH and Schultz HD: NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits. Cardiovasc Res. 75:546–554. 2007.PubMed/NCBI View Article : Google Scholar

44 

Wei Z, Jiang X, Qiao H, Zhai B, Zhang L, Zhang Q, Wu Y, Jiang H and Sun X: STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells. Cell Signal. 25:931–938. 2013.PubMed/NCBI View Article : Google Scholar

45 

Vona R, Gambardella L, Cittadini C, Straface E and Pietraforte D: Biomarkers of oxidative stress in metabolic syndrome and associated diseases. Oxid Med Cell Longev. 2019(8267234)2019.PubMed/NCBI View Article : Google Scholar

46 

Li K: Iron pathophysiology in friedreich's ataxia. Adv Exp Med Biol. 1173:125–143. 2019.PubMed/NCBI View Article : Google Scholar

47 

Cho TM, Kim JY, Kim YJ, Sung D, Oh E, Jang S, Farrand L, Hoang VH, Nguyen CT, Ann J, et al: C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition. Cancer Lett. 447:141–153. 2019.PubMed/NCBI View Article : Google Scholar

48 

Ucci M, Di Tomo P, Tritschler F, Cordone VGP, Lanuti P, Bologna G, Di Silvestre S, Di Pietro N, Pipino C, Mandatori D, et al: Anti-inflammatory role of carotenoids in endothelial cells derived from umbilical cord of women affected by gestational diabetes mellitus. Oxid Med Cell Longev. 2019(8184656)2019.PubMed/NCBI View Article : Google Scholar

49 

Li Y, Cui N, Zheng PS and Yang WT: BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. Oncotarget. 8:49238–49252. 2017.PubMed/NCBI View Article : Google Scholar

50 

Steelman LS, Abrams SL, Whelan J, Bertrand FE, Ludwig DE, Basecke J, Libra M, Stivala F, Milella M, Tafuri A, et al: Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia. 22:686–707. 2008.PubMed/NCBI View Article : Google Scholar

51 

Yang X, Yan H, Jiang N, Yu Z, Yuan J, Ni Z and Fang W: IL-6 Trans-signaling drives a STAT3-dependent pathway that leads to structural alterations of peritoneal membrane. Am J Physiol Renal Physiol. 318:F338–F353. 2020.PubMed/NCBI View Article : Google Scholar

52 

Buttura JR, Provisor Santos MN, Valieris R, Drummond RD, Defelicibus A, Lima JP, Calsavara VF, Freitas HC, Cordeiro de Lima VC, Fernanda Bartelli T, et al: Mutational signatures driven by epigenetic determinants enable the stratification of patients with gastric cancer for therapeutic intervention. Cancers (Basel). 13(490)2021.PubMed/NCBI View Article : Google Scholar

53 

Zhang Q, Wang HY, Woetmann A, Raghunath PN, Odum N and Wasik MA: STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes. Blood. 108:1058–1064. 2006.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Bai Y, Li H and Lv R: Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer. Exp Ther Med 22: 1291, 2021.
APA
Bai, Y., Li, H., & Lv, R. (2021). Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer. Experimental and Therapeutic Medicine, 22, 1291. https://doi.org/10.3892/etm.2021.10726
MLA
Bai, Y., Li, H., Lv, R."Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer". Experimental and Therapeutic Medicine 22.5 (2021): 1291.
Chicago
Bai, Y., Li, H., Lv, R."Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1291. https://doi.org/10.3892/etm.2021.10726
Copy and paste a formatted citation
x
Spandidos Publications style
Bai Y, Li H and Lv R: Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer. Exp Ther Med 22: 1291, 2021.
APA
Bai, Y., Li, H., & Lv, R. (2021). Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer. Experimental and Therapeutic Medicine, 22, 1291. https://doi.org/10.3892/etm.2021.10726
MLA
Bai, Y., Li, H., Lv, R."Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer". Experimental and Therapeutic Medicine 22.5 (2021): 1291.
Chicago
Bai, Y., Li, H., Lv, R."Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1291. https://doi.org/10.3892/etm.2021.10726
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