Open Access

Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer

  • Authors:
    • Yanfei Bai
    • Haitao Li
    • Rui Lv
  • View Affiliations

  • Published online on: September 13, 2021     https://doi.org/10.3892/etm.2021.10726
  • Article Number: 1291
  • Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Interleukin (IL)‑17 has been regarded as a significant factor in inflammation. In addition, IL‑17 is known to be involved in the progression of cancers; however, the function of IL‑17 in cervical cancer remains unclear. In the present study, cell viability was detected by Cell Counting Kit‑8 assay. Quantitative PCR and western blotting were performed to detect gene and protein expression levels, respectively, in cancer cells or tissues. Ki‑67 staining was used to evaluate cell proliferation. Wound‑healing assay was used to detect cell migration. Moreover, Transwell assay was performed to investigate the invasion of cervical cancer cells. The results revealed that IL‑17 significantly promoted the proliferation of cervical cancer cells. Additionally, IL‑17 notably enhanced the migration and invasion of cervical cancer cells in vitro. IL‑17 promoted the progression of cervical cancer via the activation of JAK2/STAT3 and PI3K/Akt/NF‑κB signaling. In conclusion, IL‑17 was a key regulator during the progression of cervical cancer through the JAK2/STAT3 and PI3K/Akt/nuclear factor‑κB signaling pathway, which may serve as a novel target for the treatment of cervical cancer.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Bai Y, Li H and Lv R: Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer. Exp Ther Med 22: 1291, 2021
APA
Bai, Y., Li, H., & Lv, R. (2021). Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer. Experimental and Therapeutic Medicine, 22, 1291. https://doi.org/10.3892/etm.2021.10726
MLA
Bai, Y., Li, H., Lv, R."Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer". Experimental and Therapeutic Medicine 22.5 (2021): 1291.
Chicago
Bai, Y., Li, H., Lv, R."Interleukin‑17 activates JAK2/STAT3, PI3K/Akt and nuclear factor‑κB signaling pathway to promote the tumorigenesis of cervical cancer". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1291. https://doi.org/10.3892/etm.2021.10726