Open Access

Brain‑derived neurotrophic factor in autoimmune inflammatory diseases (Review)

  • Authors:
    • Ningning Wang
    • Bailing Tian
  • View Affiliations

  • Published online on: September 13, 2021     https://doi.org/10.3892/etm.2021.10727
  • Article Number: 1292
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Numerous recent studies reported that brain‑derived neurotrophic factor (BDNF) also exists in the peripheral blood to regulate the proliferation, differentiation and survival of lymphocytes. Besides the role of BDNF in neuron repair, circulatory BDNF also enhances the proliferation and reduces apoptosis of lymphocytes. Peripheral lymphocytes express both BDNF and its receptors. Increasing evidence has indicated that altered BDNF serum levels significantly affect patients with autoimmune inflammatory diseases and may also be linked to the pathogenesis of diseases. For instance, systemic lupus erythematosus, an autoimmune inflammatory disease involving multiple organs, is frequently linked to altered B lymphocyte function, imbalance of T‑cell subpopulations and loss of immune tolerance, which dysregulates the immune regulatory network with excessive secretion of inflammatory cytokines. The present review summarized studies that suggest a potential link between circulatory BDNF and autoimmune inflammatory diseases.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang N and Wang N: Brain‑derived neurotrophic factor in autoimmune inflammatory diseases (Review). Exp Ther Med 22: 1292, 2021
APA
Wang, N., & Wang, N. (2021). Brain‑derived neurotrophic factor in autoimmune inflammatory diseases (Review). Experimental and Therapeutic Medicine, 22, 1292. https://doi.org/10.3892/etm.2021.10727
MLA
Wang, N., Tian, B."Brain‑derived neurotrophic factor in autoimmune inflammatory diseases (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1292.
Chicago
Wang, N., Tian, B."Brain‑derived neurotrophic factor in autoimmune inflammatory diseases (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1292. https://doi.org/10.3892/etm.2021.10727