Brain‑derived neurotrophic factor in autoimmune inflammatory diseases (Review)
- Ningning Wang
- Bailing Tian
Affiliations: Department of Gastroenterology, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Rheumatology and Immunology, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China
- Published online on: September 13, 2021 https://doi.org/10.3892/etm.2021.10727
Copyright: © Wang
et al. This is an open access article distributed under the
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Commons Attribution License.
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Numerous recent studies reported that brain‑derived neurotrophic factor (BDNF) also exists in the peripheral blood to regulate the proliferation, differentiation and survival of lymphocytes. Besides the role of BDNF in neuron repair, circulatory BDNF also enhances the proliferation and reduces apoptosis of lymphocytes. Peripheral lymphocytes express both BDNF and its receptors. Increasing evidence has indicated that altered BDNF serum levels significantly affect patients with autoimmune inflammatory diseases and may also be linked to the pathogenesis of diseases. For instance, systemic lupus erythematosus, an autoimmune inflammatory disease involving multiple organs, is frequently linked to altered B lymphocyte function, imbalance of T‑cell subpopulations and loss of immune tolerance, which dysregulates the immune regulatory network with excessive secretion of inflammatory cytokines. The present review summarized studies that suggest a potential link between circulatory BDNF and autoimmune inflammatory diseases.