Open Access

Yiqi Huoxue preserves heart function by upregulating the Sigma‑1 receptor in rats with myocardial infarction

  • Authors:
    • Lixia Lou
    • Chunhong Li
    • Jie Wang
    • Aiming Wu
    • Ting Zhang
    • Zhe Ma
    • Limin Chai
    • Dongmei Zhang
    • Yizhou Zhao
    • Bo Nie
    • Qiushuo Jin
    • Huiyang Chen
    • Wei Jing Liu
  • View Affiliations

  • Published online on: September 16, 2021     https://doi.org/10.3892/etm.2021.10743
  • Article Number: 1308
  • Copyright: © Lou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Yiqi Huoxue (YQHX) is widely used in traditional Chinese medical practice due to its reported cardioprotective effects. The aim of the present study was to investigate the mechanism underlying these effects of YQHX via the regulation of the Sigma‑1 receptor. The Sigma‑1 receptor is a chaperone protein located on the mitochondrion‑associated endoplasmic reticulum (ER) membrane. It serves an important role in heart function by regulating intracellular Ca2+ homeostasis and enhancing cellular bioenergetics. In the present study, male Sprague Dawley rats with myocardial infarction (MI)‑induced heart failure were used. MI rats were administered different treatments, including normal saline, YQHX and fluvoxamine, an agonist of the Sigma‑1 receptor. Following four weeks of treatment, YQHX was revealed to improve heart function and attenuate myocardial hypertrophy in MI rats. Additionally, YQHX increased the ATP content and improved the mitochondrial ultrastructure in the heart tissues of MI rats in comparison with acontrol. Treatment was revealed to attenuate the decreased expression of the Sigma‑1 receptor and increase the expression of inositol triphosphate type 2 receptors (IP3R2) in MI rats. By exposing H9c2 cells to angiotensin II (Ang II), YQHX prevented cell hypertrophy and normalized the decreased ATP content. However, these positive effects were partially inhibited when the Sigma‑1 receptor was knocked down via small interfering RNA transfection. The results of the present study suggested that the Sigma‑1 receptor serves an important role in the cardioprotective efficacy of YQHX by increasing ATP content and attenuating cardiomyocyte hypertrophy.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lou L, Li C, Wang J, Wu A, Zhang T, Ma Z, Chai L, Zhang D, Zhao Y, Nie B, Nie B, et al: Yiqi Huoxue preserves heart function by upregulating the Sigma‑1 receptor in rats with myocardial infarction. Exp Ther Med 22: 1308, 2021
APA
Lou, L., Li, C., Wang, J., Wu, A., Zhang, T., Ma, Z. ... Liu, W.J. (2021). Yiqi Huoxue preserves heart function by upregulating the Sigma‑1 receptor in rats with myocardial infarction. Experimental and Therapeutic Medicine, 22, 1308. https://doi.org/10.3892/etm.2021.10743
MLA
Lou, L., Li, C., Wang, J., Wu, A., Zhang, T., Ma, Z., Chai, L., Zhang, D., Zhao, Y., Nie, B., Jin, Q., Chen, H., Liu, W. J."Yiqi Huoxue preserves heart function by upregulating the Sigma‑1 receptor in rats with myocardial infarction". Experimental and Therapeutic Medicine 22.5 (2021): 1308.
Chicago
Lou, L., Li, C., Wang, J., Wu, A., Zhang, T., Ma, Z., Chai, L., Zhang, D., Zhao, Y., Nie, B., Jin, Q., Chen, H., Liu, W. J."Yiqi Huoxue preserves heart function by upregulating the Sigma‑1 receptor in rats with myocardial infarction". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1308. https://doi.org/10.3892/etm.2021.10743